What is the NOAEL for Fluorescein?
Fluorescein has 11 NOAEL studies in the database. The lowest reported value is 0 uL/min/10^6 cells in Human. Source: NTP ICE adme parameters.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Fluorescein
Also known as: 5-19-06-00456, 11712 Yellow, D+C Yellow No. 7, Benzoic acid, o-(6-hydroxy-3-oxo-3H-xanthen-9-yl)-, BRN 0094324 (+15 more)
CAS 2321-07-5
Fluorescein (CAS 2321-07-5) is a chemical substance. Key regulatory status: REACH registered, 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
NOAEL studies
NOAEL studies
11
SOURCE
Chemical inventory jurisdictions
Regulatory lists
4
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
25 fields
Name
Fluorescein
CAS Number
2321-07-5
Molecular Formula
C20H12O5
InChI Key
GNBHRKFJIUUOQI-UHFFFAOYSA-N
Monoisotopic Mass
332.068473
Synonyms
5-19-06-0045611712 YellowD+C Yellow No. 7Benzoic acid, o-(6-hydroxy-3-oxo-3H-xanthen-9-yl)-BRN 00943249-(o-Carboxyphenyl)-6-hydroxy-3H-xanthen-3-one3',6'-Dihydroxyspiro(isobenzofuran-1(3H),9'(9H)-xanthen)-3-one3,6-Dihydroxyspiro(xanthene-9,3'-phthalide)EINECS 219-031-8Fluoran, 3',6'-dihydroxy-Fluorescein RedFluoresceine
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
5 records
Dye
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
4 records
| List | Keyword | Source |
|---|---|---|
| pharmaceutical | FDA | United States Food and Drug Administration (FDA) |
| Personal care | FDA | United States Food and Drug Administration (FDA) |
| Canada; pharmaceutical | DrugBank | DrugBank |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 11 of 11 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 12.65 | uM | AC50 | - | - | NTP ICE endocrine |
| 20.55 | uM | AC50 | - | - | NTP ICE endocrine |
| 14.26 | uM | ACC | - | - | NTP ICE endocrine |
| 15.53 | uM | ACC | - | - | NTP ICE endocrine |
| 0 | uL/min/10^6 cells | Clint | - | Human | NTP ICE adme parameters |
| TPY09G7XIR | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.151 | fraction | Fu | - | Human | NTP ICE adme parameters |
| 0 | unitless | Model Score | - | - | NTP ICE endocrine |
| 0.00451 | unitless | Model Score | - | - | NTP ICE endocrine |
| 0.0354 | unitless | Model Score | - | - | NTP ICE endocrine |
| 0.191 | unitless | Model Score | - | - | NTP ICE endocrine |
Showing 11 of 11 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 2-(6-hydroxy-3-oxo-(3H)-xanthen-9-yl)benzoic acid | 219-031-8 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
-
Category
Colorant
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
FLUORESCEIN
ChEMBL Phase
4
Adverse Events
0
Bioactivity
4
Frequently Asked Questions
What regulatory lists include Fluorescein?
Fluorescein appears on 4 regulatory/inventory lists including pharmaceutical, Personal care, Canada; pharmaceutical, and 1 more. Source: EPA CPDat.
Is Fluorescein used in cosmetics?
Yes, Fluorescein is also indexed as a cosmetic ingredient under the name Acid Yellow 73. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Fluorescein come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Is Fluorescein used outside industrial chemicals?
Fluorescein also appears in cosmetics, pharmaceutical databases.