Is Acid Yellow 73 safe in cosmetics?
Acid Yellow 73 has a safety rating of "MODERATE" in our database. EU status: restricted. US status: restricted.
Moderate
Cosmetic Ingredient
Acid Yellow 73
Also known as: 5-19-06-00456, 11712 Yellow, D+C Yellow No. 7, Benzoic acid, o-(6-hydroxy-3-oxo-3H-xanthen-9-yl)-, BRN 0094324 (+15 more)
INCI: ACID YELLOW 73
Acid Yellow 73 (CAS 2321-07-5) is a cosmetic cosmetic ingredient functioning as Colorant. NOAEL 250 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: restricted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 2321-07-5 →
Auto-generated CPSR Part A draft with source citations
Function
Colorant
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
3',6'-dihydroxyspiro[2-benzofuran-3,9'-xanthene]-1-one
InChIKey
GNBHRKFJIUUOQI-UHFFFAOYSA-N
Regulatory Status
EU EU Status
restricted
US US Status
restricted
US Notes
Restricted as D&C Yellow No. 7 for externally applied drugs and cosmetics; not permitted for lip/eye area in general use without lakes; listed in 21 CFR 74.1707
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Acid Yellow 73.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Acid Yellow 73 across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Intermediate
Tonnage Band
Intermediate use only
Substance Type
SUBSTANCE
SVHC Candidate
No
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
Additional Jurisdictional Restrictions (2)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| CN | permitted_colorant | 6 | All cosmetics (Class 1) |
| ASEAN | permitted_colorant | - | All products; not products applied to mucous membranes |
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (3)
Carcinogen Classification
No indication of carcinogenicity to humans (not listed by IARC).
Source: Toxin and Toxin Target Database (T3DB)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
Skin Eye Respiratory Irritation
Eye, skin, ... and/or respiratory tract irritation.
Source: Hazardous Substances Data Bank (HSDB)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Expert Verdict
Expert safety assessment and concern-level summary for Acid Yellow 73.
Regulatory Flags
potential-allergen
colorant
Known Synonyms
5-19-06-00456
11712 Yellow
D+C Yellow No. 7
Benzoic acid, o-(6-hydroxy-3-oxo-3H-xanthen-9-yl)-
BRN 0094324
9-(o-Carboxyphenyl)-6-hydroxy-3H-xanthen-3-one
3',6'-Dihydroxyspiro(isobenzofuran-1(3H),9'(9H)-xanthen)-3-one
3,6-Dihydroxyspiro(xanthene-9,3'-phthalide)
EINECS 219-031-8
Fluoran, 3',6'-dihydroxy-
Fluorescein Red
Fluoresceine
Hidacid fluorescein
Japan Yellow No. 201
Soap Yellow F
3H-Xanthen-3-one, 9-(o-carboxyphenyl)-6-hydroxy-
Zlut kysela 73
UNII-TPY09G7XIR
2-(3-hydroxy-6-oxo-6H-xanthen-9-yl)benzoic acid
2-(6-Hydroxy-3-oxo-3H-xanthen-9-yl)-benzoic acid
Chemical Function
Dye
Regulatory Lists
pharmaceutical
Personal care
Canada; pharmaceutical
inert_ingredient; non_food_use; Pesticides
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
FLUORESCEIN
ChEMBL ID
CHEMBL1057
Max Phase
4
Frequently Asked Questions
Is Acid Yellow 73 allowed in the EU?
Acid Yellow 73 EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does Acid Yellow 73 do in cosmetics?
Acid Yellow 73 functions as: Colorant. It is classified as a cosmetic ingredient in our database. CAS number: 2321-07-5.
Is Acid Yellow 73 used outside cosmetics?
Acid Yellow 73 also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Acid Yellow 73 compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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