Moderate Cosmetic Ingredient NOAEL Data

Acid Yellow 73

INCI: ACID YELLOW 73

CAS Number
2321-07-5
Function
Colorant
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status restricted
๐Ÿ‡บ๐Ÿ‡ธ US Status restricted
US Notes Restricted as D&C Yellow No. 7 for externally applied drugs and cosmetics; not permitted for lip/eye area in general use without lakes; listed in 21 CFR 74.1707

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

2 study endpoints found for Acid Yellow 73. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 500 mg/kg bw/day oral rat oral REACH
NOAEL 250 mg/kg bw/day oral rabbit oral REACH

Expert Verdict

Restricted colorant with Annex III concentration limits; photosensitization potential under UV exposure; additional restrictions apply when used as hair dye substance.

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Concern Level: Moderate

Regulatory Flags

potential-allergen colorant

Frequently Asked Questions

Is Acid Yellow 73 safe in cosmetics?

Restricted colorant with Annex III concentration limits; photosensitization potential under UV exposure; additional restrictions apply when used as hair dye substance. The EU classifies Acid Yellow 73 as "restricted". Safety rating: MODERATE. 2 toxicological study endpoint(s) are available in our database.

Is Acid Yellow 73 allowed in the EU?

Acid Yellow 73 EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.

What does Acid Yellow 73 do in cosmetics?

Acid Yellow 73 functions as: Colorant. It is classified as a cosmetic ingredient in our database. CAS number: 2321-07-5.

What is the Margin of Safety for Acid Yellow 73?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Acid Yellow 73?

The NOAEL (No Observed Adverse Effect Level) for Acid Yellow 73 is 500 mg/kg bw/day based on a oral study via oral route in rat. A total of 2 study endpoints are available. Source: REACH.

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