What is the NOAEL for FD&C Green No. 3?
FD&C Green No. 3 has 38 NOAEL studies in the database. The lowest reported value is 0 uL/min/10^6 cells in Human. Source: NTP_ICE_adme_parameters.
NOAEL Data
IARC Group 3
REACH Registered
Cosmetic Ingredient
FD&C Green No. 3
Also known as: FD & C green No. 3 (C.I. Food Green 3, disodium salt), Aizen Food Green No. 3, Benzenemethanaminium, N-ethyl-N-(4-((4-(ethyl((3-sulfophenyl)methyl)amino)phenyl)(4-hydroxy-2-sulfophenyl)methylene)-2,5-C, EINECS 219-091-5, FD & C Green No. 3 (+5 more)
CAS 2353-45-9
FD&C Green No. 3 (CAS 2353-45-9) is a chemical substance; key hazard signal: IARC Group 3. Key regulatory status: REACH registered, 13 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, IARC, ECHA REACH.
Cross-Vertical Regulatory Divergence
FD&C Green No. 3 is classified GHS CMR hazard (H315, H319, H335, H341, H412) in the chemicals database but is restricted in EU cosmetics at max Prohibited as hair dye (Annex II Entry 1357); no maximum concentration for general colorant use.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
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noael studies public
NOAEL studies
38
SOURCE
chemical inventory jurisdictions
Regulatory lists
13
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
16 fields
Name
FD&C Green No. 3
CAS Number
2353-45-9
DTXSID
DTXSID3020673
Molecular Formula
C37H36N2O10S3.2Na
InChI Key
RZSYLLSAWYUBPE-UHFFFAOYSA-L
Monoisotopic Mass
810.132747
Synonyms
FD & C green No. 3 (C.I. Food Green 3, disodium salt)Aizen Food Green No. 3Benzenemethanaminium, N-ethyl-N-(4-((4-(ethyl((3-sulfophenyl)methyl)amino)phenyl)(4-hydroxy-2-sulfophenyl)methylene)-2,5-CEINECS 219-091-5FD & C Green No. 3Solid Green FCFZelen potravinarska 3Zelen Stala FCFUNII-3P3ONR6O1SC.I. 42053
IARC Carcinogen Classification
Carcinogenic hazard classification from IARC monograph evaluations.
SOURCE
IARC Monographs on the Identification of Carcinogenic Hazards to Humans
1 records
| Group | Meaning | Evaluated | Volume |
|---|---|---|---|
| Group 3 | Not classifiable | 1987 | 16, Sup 7 |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
13 records
DyeFragrance
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
13 records
| List | Keyword | Source |
|---|---|---|
| banned; Europe; Personal care | European Commission | CosIng |
| IFRA Transparency | IFRA | IFRA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - hair styling and care - shampoo | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| general_foods | FDA | United States Food and Drug Administration (FDA) |
| pharmaceutical | FDA | United States Food and Drug Administration (FDA) |
| Personal care | FDA | United States Food and Drug Administration (FDA) |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 38 of 38 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 11.86188925 | uM | AC50 | - | - | NTP_ICE_endocrine |
| 7.982783792 | uM | ACC | - | - | NTP_ICE_endocrine |
| <=25 | mg/kg | ADI | oral | Human | ToxValDB_WHO_JECFA_ADI |
| - | uL/min/10^6 cells | Clint | - | Human | NTP_ICE_adme_parameters |
| =89.957 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 3P3ONR6O1S | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3P3ONR6O1S | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3P3ONR6O1S | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3P3ONR6O1S | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 9J3VQ0Y6BV | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 9J3VQ0Y6BV | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 9J3VQ0Y6BV | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 9J3VQ0Y6BV | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.0151 | fraction | Fu | - | Human | NTP_ICE_adme_parameters |
| 3 | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 3 | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 3 | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 3 | unitless | IARC group | - | - | NTP_ICE_cancer |
| >2000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =48.75 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 0.209 | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 500 | mg/kg bw/day | NOAEL | oral | dog | COSMOS_DB |
| =500 | mg/kg bw/day | NOAEL | oral | Dog | ToxValDB_ECHA_IUCLID |
| 992 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS_DB |
| 1000 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| =1000 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| 1250 | mg/kg bw/day | NOAEL | oral | rabbit | COSMOS_DB |
| =1321.43 | mg/kg bw/day | NOAEL | oral | Mouse | ToxValDB_ECHA_IUCLID |
| =1428.5 | mg/kg bw/day | NOAEL | dermal | Mouse | ToxValDB_ECHA_IUCLID |
| 2000 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 2500 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| =2500 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =2857 | mg/kg bw/day | NOAEL | oral | Mouse | ToxValDB_ECHA_IUCLID |
| 3000 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS_DB |
| 3602 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| =7142.85 | mg/kg bw/day | NOAEL | oral | Mouse | ToxValDB_ECHA_IUCLID |
| =2000 | mg/kg bw/day | NOEL | oral | Mouse | ToxValDB_ECOTOX |
Showing 38 of 38 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Dihydrogen (ethyl)[4-[4-[ethyl(3-sulphonatobenzyl)amino](4-hydroxy-2-sulphonatobenzhydrylidene]cyclohexa-2,5-dien-1-ylidene](3-sulphonatobenzyl)ammonium, disodium salt | 219-091-5 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
Prohibited as hair dye (Annex II Entry 1357); no maximum concentration for general colorant use
Category
colorant
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL3188843
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
E143 — ADI: 25 mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include FD&C Green No. 3?
FD&C Green No. 3 appears on 10 regulatory/inventory lists including banned; Europe; Personal care, IFRA Transparency, children; Europe; Personal care, and 7 more. Source: EPA CPDat.
Is FD&C Green No. 3 a carcinogen according to IARC?
FD&C Green No. 3 is classified by IARC as Group 3 — not classifiable as to its carcinogenicity to humans (evaluated 1987). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.
Is FD&C Green No. 3 used in cosmetics?
Yes, FD&C Green No. 3 is also indexed as a cosmetic ingredient under the name Fast Green FCF. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for FD&C Green No. 3 come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, IARC Monographs, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does FD&C Green No. 3 have different safety status in cosmetics vs industrial chemicals?
FD&C Green No. 3 is classified GHS CMR hazard (H315, H319, H335, H341, H412) in the chemicals database but is restricted in EU cosmetics at max Prohibited as hair dye (Annex II Entry 1357); no maximum concentration for general colorant use.
Is FD&C Green No. 3 used outside industrial chemicals?
FD&C Green No. 3 also appears in cosmetics, pharmaceutical, food safety, cannabis databases.