Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Fast Green FCF. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 1250 mg/kg bw/day | oral | rabbit | Developmental | COSMOS_DB |
| NOAEL | 1250 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
| NOAEL | 2000 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| NOAEL | 2500 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| NOAEL | 3000 mg/kg bw/day | oral | mouse | Chronic | COSMOS_DB |
| NOAEL | 500 mg/kg bw/day | oral | dog | Chronic | COSMOS_DB |
| NOAEL | 1000 mg/kg bw/day | oral | rat | Multigeneration Reproductive | COSMOS_DB |
| NOAEL | 1000 mg/kg bw/day | oral | rat | Reproductive-developmental | COSMOS_DB |
| NOAEL | 3602 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| NOAEL | 3602 mg/kg bw/day | oral | rat | Carcinogenicity | COSMOS_DB |
Expert Verdict
Permitted as a general colorant under Annex IV, but prohibited for use as a hair dye substance (Annex II Entry 1357). Certification required in the US.
Regulatory Flags
Frequently Asked Questions
Is Fast Green FCF safe in cosmetics?
Permitted as a general colorant under Annex IV, but prohibited for use as a hair dye substance (Annex II Entry 1357). Certification required in the US. The EU classifies Fast Green FCF as "restricted". Safety rating: GOOD. 10 toxicological study endpoint(s) are available in our database.
Is Fast Green FCF allowed in the EU?
Fast Green FCF EU regulatory status: restricted. Maximum allowed concentration: Prohibited as hair dye (Annex II Entry 1357); no maximum concentration for general colorant use. This is based on EU Regulation 1223/2009 and its amendments.
What does Fast Green FCF do in cosmetics?
Fast Green FCF functions as: Colorant (green). It is classified as a Colorant in our database. CAS number: 2353-45-9.
What is the Margin of Safety for Fast Green FCF?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Fast Green FCF?
The NOAEL (No Observed Adverse Effect Level) for Fast Green FCF is 1250 mg/kg bw/day based on a Developmental study via oral route in rabbit. A total of 10 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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