What is the NOAEL for Damascenone?
Damascenone has 13 NOAEL studies in the database. The lowest reported value is 0.175 % via Dermal in Human. Source: NTP_ICE_skin_sensitization.
NOAEL Data
Cosmetic Ingredient
Damascenone
Also known as: 2-Buten-1-one, 1-(2,6,6-trimethyl-1,3-cyclohexadien-1-yl)-, beta-Damascenone, EINECS 245-833-2, FEMA No. 3420, UNII-U66V25TBO0
CAS 23696-85-7
Damascenone (CAS 23696-85-7) is a chemical substance. Key regulatory status: 5 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.
SOURCE
noael studies public
NOAEL studies
13
SOURCE
chemical inventory jurisdictions
Regulatory lists
5
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
11 fields
Name
Damascenone
CAS Number
23696-85-7
DTXSID
DTXSID6041397
Molecular Formula
C13H18O
InChI Key
POIARNZEYGURDG-UHFFFAOYSA-N
Monoisotopic Mass
190.135765
Synonyms
2-Buten-1-one, 1-(2,6,6-trimethyl-1,3-cyclohexadien-1-yl)-beta-DamascenoneEINECS 245-833-2FEMA No. 3420UNII-U66V25TBO0
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
26 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
5 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| Europe | European Commission | Fl@vis |
| Europe; Personal care; restricted | European Commission | CosIng |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 13 of 13 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 0.175 | % | Concentration, 5% incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 7.5 | % | Concentration, 5% incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 0.25 | % | Concentration, one positive response | Dermal | Human | NTP_ICE_skin_sensitization |
| U66V25TBO0 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| U66V25TBO0 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| U66V25TBO0 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| U66V25TBO0 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 2 | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 14.29 | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 100 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
| 4 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 13 of 13 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
0.02%
Category
Fragrance
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Damascenone?
Damascenone appears on 5 regulatory/inventory lists including IFRA Transparency, inert_ingredient; non_food_use; Pesticides, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), and 2 more. Source: EPA CPDat.
Is Damascenone used in cosmetics?
Yes, Damascenone is also indexed as a cosmetic ingredient under the name Rose Ketone-4. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Damascenone come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Damascenone used outside industrial chemicals?
Damascenone also appears in cosmetics, cannabis databases.