Moderate Cosmetic Ingredient Sensitization Data

Rose Ketone-4

INCI: ROSE KETONE-4

CAS Number
23696-85-7
Function
Fragrance
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status restricted
EU Max Conc. 0.02%
๐Ÿ‡บ๐Ÿ‡ธ US Status restricted
US Notes Permitted in fragrances; IFRA restricted

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
high
Sensitization
high

Calculate MoS for your specific formulation with the MoS Calculator.

Sensitization Profile

Contact sensitization data for Rose Ketone-4 based on clinical patch test studies and IFRA standards.

Sensitization Rate
low
Allergen Class
fragrance
EU Allergen Listed
yes
Patch Test Positive Rate
0.2%
Cross-reactivity Group
none
Reaction Type
contact-dermatitis
IFRA Restricted

Source: EU 2023/1545; SCCS

Expert Verdict

๐Ÿ”ด Annex III/160 restricted; max 0.02% in non-oral products; must be individually declared on label; IFRA compliance mandatory; known sensitizer requiring strict batch-level concentration verification

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Concern Level: Moderate

Regulatory Flags

potential-allergen fragrance-component ifra_fragrance fda_food_additive eu_cosing_listed

Frequently Asked Questions

Is Rose Ketone-4 safe in cosmetics?

๐Ÿ”ด Annex III/160 restricted; max 0.02% in non-oral products; must be individually declared on label; IFRA compliance mandatory; known sensitizer requiring strict batch-level concentration verification The EU classifies Rose Ketone-4 as "restricted". Safety rating: MODERATE.

Is Rose Ketone-4 allowed in the EU?

Rose Ketone-4 EU regulatory status: restricted. Maximum allowed concentration: 0.02%. This is based on EU Regulation 1223/2009 and its amendments.

What does Rose Ketone-4 do in cosmetics?

Rose Ketone-4 functions as: Fragrance. It is classified as a cosmetic ingredient in our database. CAS number: 23696-85-7.

What is the Margin of Safety for Rose Ketone-4?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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