NOAEL Data REACH Registered Cosmetic Ingredient

2-Ethoxyethyl methacrylate

Also known as: 2-Propenoic acid, 2-methyl-, 2-ethoxyethyl ester, EINECS 219-135-3, Ethoxyethyl methacrylate, Methacrylic acid, 2-ethoxyethyl ester, NSC 24162 (+1 more)

CAS 2370-63-0

2-Ethoxyethyl methacrylate (CAS 2370-63-0) is a chemical substance. Key regulatory status: REACH registered, 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.

View cosmetic safety profile for Ethoxyethyl Methacrylate (2-Ethoxyethyl Methacrylate) →

Cross-Vertical Regulatory Divergence

2-Ethoxyethyl methacrylate is prohibited in EU cosmetics but has active industrial GHS classifications (H315, H319, H335, H360, H360FD).

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 12 fields

Name

2-Ethoxyethyl methacrylate

CAS Number

2370-63-0

DTXSID

DTXSID1022186

Molecular Formula

C8H14O3

InChI Key

SFPNZPQIIAJXGL-UHFFFAOYSA-N

Monoisotopic Mass

158.094294

Synonyms

2-Propenoic acid, 2-methyl-, 2-ethoxyethyl esterEINECS 219-135-3Ethoxyethyl methacrylateMethacrylic acid, 2-ethoxyethyl esterNSC 24162UNII-5Q6XR4MR8E

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 2 records

Film former

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 2 records

List	Keyword	Source
Europe; Personal care - nails	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Personal care - nails - nail polish	Danish Environmental Protection Agency	Danish EPA

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 22 of 22 studies

Value	Unit	Endpoint	Route	Species	Source
=7.06	mg/m3	DNEL systemic	inhalation	Human	ToxValDB_GESTIS_DNEL
77.9	min	ET50	Dermal	-	NTP_ICE_skin_irritation
5Q6XR4MR8E	UNII	FDA UNII substance identifier	-	-	openFDA substances
5Q6XR4MR8E	UNII	FDA UNII substance identifier	-	-	openFDA substances
5Q6XR4MR8E	UNII	FDA UNII substance identifier	-	-	openFDA substances
5Q6XR4MR8E	UNII	FDA UNII substance identifier	-	-	openFDA substances
68.6	%	Viability	Dermal	-	NTP_ICE_skin_irritation
92.5	%	Viability	Dermal	-	NTP_ICE_skin_irritation
99.5	%	Viability	Dermal	-	NTP_ICE_skin_irritation
104.8	%	Viability	Dermal	-	NTP_ICE_skin_irritation
116.3	%	Viability	Dermal	-	NTP_ICE_skin_irritation
81	%	Viability (18 hours)	Dermal	-	NTP_ICE_skin_irritation
125.8	%	Viability (240 minutes)	Dermal	-	NTP_ICE_skin_irritation
154.6	%	Viability (240 minutes)	Dermal	-	NTP_ICE_skin_irritation
164.5	%	Viability (240 minutes)	Dermal	-	NTP_ICE_skin_irritation
132	%	Viability (3 minutes)	Dermal	-	NTP_ICE_skin_irritation
133.1	%	Viability (3 minutes)	Dermal	-	NTP_ICE_skin_irritation
142	%	Viability (3 minutes)	Dermal	-	NTP_ICE_skin_irritation
62.1	%	Viability (42 hours)	Dermal	-	NTP_ICE_skin_irritation
133.2	%	Viability (60 minutes)	Dermal	-	NTP_ICE_skin_irritation
139.6	%	Viability (60 minutes)	Dermal	-	NTP_ICE_skin_irritation
139.7	%	Viability (60 minutes)	Dermal	-	NTP_ICE_skin_irritation

Showing 22 of 22 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	2-ethoxyethyl methacrylate	219-135-3	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed_with_terms

Conditions

Specific information requirements: Obligations to provide information apply. You must tell the Executive Director the volume of introduction, use and end use of the chemical within 20 working days if: ; the chemical is being introduced for consumer end use except in articles.

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

prohibited

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL CHEMBL1414186

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Frequently Asked Questions

What is the NOAEL for 2-Ethoxyethyl methacrylate?

2-Ethoxyethyl methacrylate has 22 NOAEL studies in the database. The lowest reported value is 7.06 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.

What regulatory lists include 2-Ethoxyethyl methacrylate?

2-Ethoxyethyl methacrylate appears on 2 regulatory/inventory lists including Europe; Personal care - nails, detected; Europe; Personal care - nails - nail polish. Source: EPA CPDat.

Is 2-Ethoxyethyl methacrylate used in cosmetics?

Yes, 2-Ethoxyethyl methacrylate is also indexed as a cosmetic ingredient under the name Ethoxyethyl Methacrylate (2-Ethoxyethyl Methacrylate). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 2-Ethoxyethyl methacrylate come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Does 2-Ethoxyethyl methacrylate have different safety status in cosmetics vs industrial chemicals?

2-Ethoxyethyl methacrylate is prohibited in EU cosmetics but has active industrial GHS classifications (H315, H319, H335, H360, H360FD).

Is 2-Ethoxyethyl methacrylate used outside industrial chemicals?

2-Ethoxyethyl methacrylate also appears in cosmetics, pharmaceutical databases.