Ethoxyethyl Methacrylate (2-Ethoxyethyl Methacrylate)
INCI: ETHOXYETHYL METHACRYLATE
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
4 study endpoints found for Ethoxyethyl Methacrylate (2-Ethoxyethyl Methacrylate). NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 20000 mg/L drinking water | oral | mouse | oral | REACH |
| NOAEL | 1250 mg/L drinking water | oral | rat | oral | REACH |
| NOEL | 23 mg/kg bw/day | oral | code:3544 | oral | REACH |
| NOAEL | 163 mg/kg bw/day | oral | - | oral | REACH |
Expert Verdict
Strong skin sensitizer as monomer with well-documented cross-reactivity to other methacrylates (methyl methacrylate, HEMA, etc.). Must not be used in leave-on skin products and requires explicit skin-avoidance labeling.
Regulatory Flags
Frequently Asked Questions
Is Ethoxyethyl Methacrylate (2-Ethoxyethyl Methacrylate) safe in cosmetics?
Strong skin sensitizer as monomer with well-documented cross-reactivity to other methacrylates (methyl methacrylate, HEMA, etc.). Must not be used in leave-on skin products and requires explicit skin-avoidance labeling. The EU classifies Ethoxyethyl Methacrylate (2-Ethoxyethyl Methacrylate) as "prohibited". Safety rating: MODERATE. 4 toxicological study endpoint(s) are available in our database.
Is Ethoxyethyl Methacrylate (2-Ethoxyethyl Methacrylate) allowed in the EU?
Ethoxyethyl Methacrylate (2-Ethoxyethyl Methacrylate) EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Ethoxyethyl Methacrylate (2-Ethoxyethyl Methacrylate) do in cosmetics?
Ethoxyethyl Methacrylate (2-Ethoxyethyl Methacrylate) functions as: Film former / nail enhancement monomer. It is classified as a cosmetic ingredient in our database. CAS number: 2370-63-0.
What is the Margin of Safety for Ethoxyethyl Methacrylate (2-Ethoxyethyl Methacrylate)?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Ethoxyethyl Methacrylate (2-Ethoxyethyl Methacrylate)?
The NOAEL (No Observed Adverse Effect Level) for Ethoxyethyl Methacrylate (2-Ethoxyethyl Methacrylate) is 20000 mg/L drinking water based on a oral study via oral route in mouse. A total of 4 study endpoints are available. Source: REACH.
Compliance Tools
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Related Ingredients
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