Is Ethoxyethyl Methacrylate (2-Ethoxyethyl Methacrylate) safe in cosmetics?
Ethoxyethyl Methacrylate (2-Ethoxyethyl Methacrylate) has a safety rating of "MODERATE" in our database. EU status: prohibited. US status: permitted.
Moderate
Cosmetic Ingredient
Ethoxyethyl Methacrylate (2-Ethoxyethyl Methacrylate)
Also known as: 2-Propenoic acid, 2-methyl-, 2-ethoxyethyl ester, EINECS 219-135-3, Methacrylic acid, 2-ethoxyethyl ester, NSC 24162, UNII-5Q6XR4MR8E
INCI: ETHOXYETHYL METHACRYLATE
Ethoxyethyl Methacrylate (2-Ethoxyethyl Methacrylate) (CAS 2370-63-0) is a cosmetic cosmetic ingredient functioning as Film former / nail enhancement monomer. NOAEL 163 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 2370-63-0 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Ethoxyethyl Methacrylate (2-Ethoxyethyl Methacrylate) is prohibited in EU cosmetics but has active industrial GHS classifications (H315, H319, H335, H360, H360FD).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Film former / nail enhancement monomer
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
2-ethoxyethyl 2-methylprop-2-enoate
InChIKey
SFPNZPQIIAJXGL-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
Permitted. CIR Expert Panel concluded methacrylate ester monomers safe as used in nail products when accompanied by directions to avoid skin contact.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Ethoxyethyl Methacrylate (2-Ethoxyethyl Methacrylate).
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Ethoxyethyl Methacrylate (2-Ethoxyethyl Methacrylate) across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Film former
Expert Verdict
Expert safety assessment and concern-level summary for Ethoxyethyl Methacrylate (2-Ethoxyethyl Methacrylate).
Regulatory Flags
potential-allergen
Known Synonyms
2-Propenoic acid, 2-methyl-, 2-ethoxyethyl ester
EINECS 219-135-3
Methacrylic acid, 2-ethoxyethyl ester
NSC 24162
UNII-5Q6XR4MR8E
Chemical Function
Film former
Regulatory Lists
Europe; Personal care - nails
detected; Europe; Personal care - nails - nail polish
Australian Status
AICIS status: listed_with_terms
Specific information requirements: Obligations to provide information apply. You must tell the Executive Director the volume of introduction, use and end use of the chemical within 20 working days if: ; the chemical is being introduced for consumer end use except in articles.
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL1414186
Frequently Asked Questions
Is Ethoxyethyl Methacrylate (2-Ethoxyethyl Methacrylate) allowed in the EU?
Ethoxyethyl Methacrylate (2-Ethoxyethyl Methacrylate) EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Ethoxyethyl Methacrylate (2-Ethoxyethyl Methacrylate) do in cosmetics?
Ethoxyethyl Methacrylate (2-Ethoxyethyl Methacrylate) functions as: Film former / nail enhancement monomer. It is classified as a cosmetic ingredient in our database. CAS number: 2370-63-0.
Is Ethoxyethyl Methacrylate (2-Ethoxyethyl Methacrylate) used outside cosmetics?
Ethoxyethyl Methacrylate (2-Ethoxyethyl Methacrylate) also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Ethoxyethyl Methacrylate (2-Ethoxyethyl Methacrylate) have different safety status in cosmetics vs industrial chemicals?
Ethoxyethyl Methacrylate (2-Ethoxyethyl Methacrylate) is prohibited in EU cosmetics but has active industrial GHS classifications (H315, H319, H335, H360, H360FD).
Compliance Tools
Check Ethoxyethyl Methacrylate (2-Ethoxyethyl Methacrylate) compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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