What is the NOAEL for 4-Methyl-2-tert-butylphenol?
4-Methyl-2-tert-butylphenol has 10 NOAEL studies in the database. The lowest reported value is 13.5499865034854 uM. Source: NTP_ICE_endocrine.
NOAEL Data
REACH Registered
Cosmetic Ingredient
4-Methyl-2-tert-butylphenol
Also known as: 2-(1,1-Dimethylethyl)-4-methyl-phenol, Phenol, 2-(1,1-dimethylethyl)-4-methyl-, 2-tert-Butyl-4-methylphenol, 4-Methyl-2-(2-methyl-2-propanyl)phenol, 4-06-00-03397 (+14 more)
CAS 2409-55-4
4-Methyl-2-tert-butylphenol (CAS 2409-55-4) is a chemical substance. Key regulatory status: REACH registered, 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
4-Methyl-2-tert-butylphenol is classified GHS Danger (H314, H318, H335, H411, H315, H319, H401) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
10
SOURCE
chemical inventory jurisdictions
Regulatory lists
1
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
25 fields
Name
4-Methyl-2-tert-butylphenol
CAS Number
2409-55-4
DTXSID
DTXSID2020212
Molecular Formula
C11H16O
InChI Key
IKEHOXWJQXIQAG-UHFFFAOYSA-N
Monoisotopic Mass
164.120115
Synonyms
2-(1,1-Dimethylethyl)-4-methyl-phenolPhenol, 2-(1,1-dimethylethyl)-4-methyl-2-tert-Butyl-4-methylphenol4-Methyl-2-(2-methyl-2-propanyl)phenol4-06-00-03397BRN 1817645o-tert-Butyl-p-cresol2-t-Butyl-p-cresol2-tert-Butyl-4-methyl-1-phenol2-(1,1-Dimethylethyl)-4-methylphenolEINECS 219-314-61-Hydroxy-2-tert-butyl-4-methylbenzene
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
3 records
FragranceAntioxidant
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
1 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 10 of 10 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 15.5263012665188 | uM | AC50 | - | - | NTP_ICE_endocrine |
| 13.5499865034854 | uM | ACC | - | - | NTP_ICE_endocrine |
| 20.9 | uL/min/10^6 cells | Clint | - | Human | NTP_ICE_adme_parameters |
| Y9VVU7G7J4 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| Y9VVU7G7J4 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| Y9VVU7G7J4 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| Y9VVU7G7J4 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.0272 | fraction | Fu | - | Human | NTP_ICE_adme_parameters |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 0.0164 | unitless | Model Score | - | - | NTP_ICE_endocrine |
Showing 10 of 10 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 2-tert-butyl-p-cresol | 219-314-6 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL281976
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Frequently Asked Questions
What regulatory lists include 4-Methyl-2-tert-butylphenol?
4-Methyl-2-tert-butylphenol appears on 1 regulatory/inventory list including IFRA Transparency. Source: EPA CPDat.
Is 4-Methyl-2-tert-butylphenol used in cosmetics?
Yes, 4-Methyl-2-tert-butylphenol is also indexed as a cosmetic ingredient under the name 2-Tert-Butyl-P-Cresol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 4-Methyl-2-tert-butylphenol come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does 4-Methyl-2-tert-butylphenol have different safety status in cosmetics vs industrial chemicals?
4-Methyl-2-tert-butylphenol is classified GHS Danger (H314, H318, H335, H411, H315, H319, H401) in the chemicals database but is allowed in EU cosmetics.
Is 4-Methyl-2-tert-butylphenol used outside industrial chemicals?
4-Methyl-2-tert-butylphenol also appears in cosmetics, pharmaceutical databases.