Is 2-Tert-Butyl-P-Cresol safe in cosmetics?
2-Tert-Butyl-P-Cresol has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
2-Tert-Butyl-P-Cresol
Also known as: 2-(1,1-Dimethylethyl)-4-methyl-phenol, Phenol, 2-(1,1-dimethylethyl)-4-methyl-, 2-tert-Butyl-4-methylphenol, 4-Methyl-2-(2-methyl-2-propanyl)phenol, 4-06-00-03397 (+14 more)
INCI: 2-TERT-BUTYL-P-CRESOL
2-Tert-Butyl-P-Cresol (CAS 2409-55-4) is a cosmetic cosmetic ingredient functioning as Perfuming / Antioxidant. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 2409-55-4 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
2-Tert-Butyl-P-Cresol is classified GHS Danger (H314, H318, H335, H411, H315, H319, H401) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Perfuming / Antioxidant
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
2-tert-butyl-4-methylphenol
InChIKey
IKEHOXWJQXIQAG-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — no specific FDA cosmetic restriction; related to GRAS-listed antioxidants
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for 2-Tert-Butyl-P-Cresol.
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Intermediate
Tonnage Band
Intermediate use only
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Antioxidant
Fragrance
Regulatory List Membership (1)
IFRA Fragrance Transparency List
Expert Verdict
Expert safety assessment and concern-level summary for 2-Tert-Butyl-P-Cresol.
Regulatory Flags
fragrance-component
ifra_fragrance
Known Synonyms
2-(1,1-Dimethylethyl)-4-methyl-phenol
Phenol, 2-(1,1-dimethylethyl)-4-methyl-
2-tert-Butyl-4-methylphenol
4-Methyl-2-(2-methyl-2-propanyl)phenol
4-06-00-03397
BRN 1817645
o-tert-Butyl-p-cresol
2-t-Butyl-p-cresol
2-tert-Butyl-4-methyl-1-phenol
2-(1,1-Dimethylethyl)-4-methylphenol
EINECS 219-314-6
1-Hydroxy-2-tert-butyl-4-methylbenzene
4-Methyl-2-t-butylphenol
4-Methyl-6-t-butylphenol
4-Methyl-2-(1,1-dimethylethyl)phenol
NSC 60301
2-terc.Butyl-p-kresol
UNII-Y9VVU7G7J4
2-(Tert-Butyl)-4-Methylphenol
Chemical Function
Fragrance
Antioxidant
Regulatory Lists
IFRA Transparency
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL281976
Frequently Asked Questions
Is 2-Tert-Butyl-P-Cresol allowed in the EU?
2-Tert-Butyl-P-Cresol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does 2-Tert-Butyl-P-Cresol do in cosmetics?
2-Tert-Butyl-P-Cresol functions as: Perfuming / Antioxidant. It is classified as a cosmetic ingredient in our database. CAS number: 2409-55-4.
Is 2-Tert-Butyl-P-Cresol used outside cosmetics?
2-Tert-Butyl-P-Cresol also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does 2-Tert-Butyl-P-Cresol have different safety status in cosmetics vs industrial chemicals?
2-Tert-Butyl-P-Cresol is classified GHS Danger (H314, H318, H335, H411, H315, H319, H401) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check 2-Tert-Butyl-P-Cresol compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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