What is the NOAEL for 2,3,6-Trimethylphenol?
2,3,6-Trimethylphenol has 11 NOAEL studies in the database. The lowest reported value is 0.0908 fraction in Human. Source: NTP ICE adme parameters.
NOAEL Data
REACH Registered
Cosmetic Ingredient
2,3,6-Trimethylphenol
Also known as: Phenol, 2,3,6-trimethyl-, EINECS 219-330-3, 3-Hydroxypseudocumene, 1-Hydroxy-2,3,6-trimethylbenzene, NSC 91509 (+1 more)
CAS 2416-94-6
2,3,6-Trimethylphenol (CAS 2416-94-6) is a chemical substance. Key regulatory status: REACH registered, 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
2,3,6-Trimethylphenol is classified GHS Danger (H314, H315, H317, H318, H302, H319, H371, H373) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
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NOAEL studies
NOAEL studies
11
SOURCE
Chemical inventory jurisdictions
Regulatory lists
3
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EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
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DSSTox identifiers
11 fields
Name
2,3,6-Trimethylphenol
CAS Number
2416-94-6
Molecular Formula
C9H12O
InChI Key
QQOMQLYQAXGHSU-UHFFFAOYSA-N
Monoisotopic Mass
136.088815
Synonyms
Phenol, 2,3,6-trimethyl-EINECS 219-330-33-Hydroxypseudocumene1-Hydroxy-2,3,6-trimethylbenzeneNSC 91509UNII-05WKL2L5LJ
Functional Uses
Industrial and product-use categories associated with this substance.
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EPA CPDat
4 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
3 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
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NOAEL studies
Showing 11 of 11 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 106 | uL/min/10^6 cells | Clint | - | Human | NTP ICE adme parameters |
| =9.79 | mg/m3 | DNEL local | inhalation | Human | ToxValDB GESTIS DNEL |
| 05WKL2L5LJ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.0908 | fraction | Fu | - | Human | NTP ICE adme parameters |
| =300 | mg/kg bw/day | LOAEL | oral | Rat | ECHA |
| ~1346 | mg/kg bw/day | LOAEL | oral | Rat | ECHA |
| 0 | unitless | Model Score | - | - | NTP ICE endocrine |
| ~55 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| =100 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| ~273 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| =1000 | mM | NOEL | dermal | Mouse | ToxValDB ECOTOX |
Showing 11 of 11 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
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ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 2,3,6-trimethylphenol | 219-330-3 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
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ChEMBL / DailyMed
CHEMBL3182738
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
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Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include 2,3,6-Trimethylphenol?
2,3,6-Trimethylphenol appears on 3 regulatory/inventory lists including IFRA Transparency, Europe, food_additive; Substances Added to Food (formerly EAFUS) (2/2019). Source: EPA CPDat.
Is 2,3,6-Trimethylphenol used in cosmetics?
Yes, 2,3,6-Trimethylphenol is also indexed as a cosmetic ingredient under the name 2,3,6-Trimethylphenol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 2,3,6-Trimethylphenol come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does 2,3,6-Trimethylphenol have different safety status in cosmetics vs industrial chemicals?
2,3,6-Trimethylphenol is classified GHS Danger (H314, H315, H317, H318, H302, H319, H371, H373) in the chemicals database but is allowed in EU cosmetics.
Is 2,3,6-Trimethylphenol used outside industrial chemicals?
2,3,6-Trimethylphenol also appears in cosmetics, pharmaceutical, cannabis databases.