Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
3 study endpoints found for 2,3,6-Trimethylphenol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | ca.273 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 100 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | >=200 mg/kg bw/day | oral | rat | oral | REACH |
Expert Verdict
Phenol derivative - monitor for skin irritation; ensure use concentration is within IFRA limits; corrosive/irritant properties possible at elevated concentrations
Regulatory Flags
Frequently Asked Questions
Is 2,3,6-Trimethylphenol safe in cosmetics?
Phenol derivative - monitor for skin irritation; ensure use concentration is within IFRA limits; corrosive/irritant properties possible at elevated concentrations The EU classifies 2,3,6-Trimethylphenol as "permitted". Safety rating: MODERATE. 3 toxicological study endpoint(s) are available in our database.
Is 2,3,6-Trimethylphenol allowed in the EU?
2,3,6-Trimethylphenol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does 2,3,6-Trimethylphenol do in cosmetics?
2,3,6-Trimethylphenol functions as: Fragrance. It is classified as a cosmetic ingredient in our database. CAS number: 2416-94-6.
What is the Margin of Safety for 2,3,6-Trimethylphenol?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for 2,3,6-Trimethylphenol?
The NOAEL (No Observed Adverse Effect Level) for 2,3,6-Trimethylphenol is ca.273 mg/kg bw/day based on a oral study via oral route in rat. A total of 3 study endpoints are available. Source: REACH.
Compliance Tools
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Related Ingredients
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