What is the NOAEL for 2-(2H-Benzotriazol-2-yl)-4-methylphenol?
2-(2H-Benzotriazol-2-yl)-4-methylphenol has 10 NOAEL studies in the database. The lowest reported value is 1 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
2-(2H-Benzotriazol-2-yl)-4-methylphenol
Also known as: 2-(2H-Benzotriazol-2-yl)-p-cresol, Phenol, 2-(2H-benzotriazol-2-yl)-4-methyl-, BRN 0615546, EINECS 219-470-5, Porex P (+4 more)
CAS 2440-22-4
2-(2H-Benzotriazol-2-yl)-4-methylphenol (CAS 2440-22-4) is a chemical substance. Key regulatory status: REACH registered, 11 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
10
SOURCE
chemical inventory jurisdictions
Regulatory lists
11
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
15 fields
Name
2-(2H-Benzotriazol-2-yl)-4-methylphenol
CAS Number
2440-22-4
DTXSID
DTXSID1027479
Molecular Formula
C13H11N3O
InChI Key
MCPKSFINULVDNX-UHFFFAOYSA-N
Monoisotopic Mass
225.090212
Synonyms
2-(2H-Benzotriazol-2-yl)-p-cresolPhenol, 2-(2H-benzotriazol-2-yl)-4-methyl-BRN 0615546EINECS 219-470-5Porex PUV absorber-1DrometrizolDrometrizolumUNII-5X93W9OFZL
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
55 records
UV stabilizerStabilizing agentFragranceDye
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
11 records
| List | Keyword | Source |
|---|---|---|
| CEDI | FDA | United States Food and Drug Administration (FDA) |
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
| drinking_water; Europe; manufacturing; plastic_additive | Belgaqua | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| Europe; plastic_additive | European Chemicals Agency | European Chemicals Agency (ECHA) |
| detected; Europe; Other indirect contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| detected; emissions; Europe; Other indirect contact consumer goods; water | Danish Environmental Protection Agency | Danish EPA |
| pharmaceutical | US International Trade Commission | CPCat |
| IFRA Transparency | IFRA | IFRA |
| artificial_sweat; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| artificial_sweat; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 10 of 10 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 8.70052633809247 | uM | AC50 | - | - | NTP_ICE_endocrine |
| 2.31681441971436 | uM | ACC | - | - | NTP_ICE_endocrine |
| =1 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 5X93W9OFZL | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 5X93W9OFZL | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 5X93W9OFZL | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 5X93W9OFZL | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 0.0875 | unitless | Model Score | - | - | NTP_ICE_endocrine |
| <30 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_HESS |
Showing 10 of 10 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 2-(2H-benzotriazol-2-yl)-p-cresol | 219-470-5 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
DROMETRIZOLE
ChEMBL Phase
3
Adverse Events
0
Bioactivity
2
Frequently Asked Questions
What regulatory lists include 2-(2H-Benzotriazol-2-yl)-4-methylphenol?
2-(2H-Benzotriazol-2-yl)-4-methylphenol appears on 10 regulatory/inventory lists including CEDI, Indirect additives food contact (10/2018), drinking_water; Europe; manufacturing; plastic_additive, and 7 more. Source: EPA CPDat.
Is 2-(2H-Benzotriazol-2-yl)-4-methylphenol used in cosmetics?
Yes, 2-(2H-Benzotriazol-2-yl)-4-methylphenol is also indexed as a cosmetic ingredient under the name Drometrizole. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 2-(2H-Benzotriazol-2-yl)-4-methylphenol come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Is 2-(2H-Benzotriazol-2-yl)-4-methylphenol used outside industrial chemicals?
2-(2H-Benzotriazol-2-yl)-4-methylphenol also appears in cosmetics, pharmaceutical databases.