Is Drometrizole safe in cosmetics?
Drometrizole has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Drometrizole
Also known as: 2-(2H-Benzotriazol-2-yl)-p-cresol, Phenol, 2-(2H-benzotriazol-2-yl)-4-methyl-, BRN 0615546, EINECS 219-470-5, Porex P (+4 more)
INCI: DROMETRIZOLE
Drometrizole (CAS 2440-22-4) is a cosmetic cosmetic ingredient functioning as UV absorber; fragrance functional. NOAEL 30 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 2440-22-4 →
Auto-generated CPSR Part A draft with source citations
Function
UV absorber; fragrance functional
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
2-(benzotriazol-2-yl)-4-methylphenol
InChIKey
MCPKSFINULVDNX-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — not restricted; CIR Amended Final Report concluded safe as used in cosmetics
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Drometrizole.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Drometrizole across SCCS product categories, with measured dermal absorption where available.
Endocrine Disruptor Evidence (Expanded)
Cross-referenced EDC classifications, mechanism data, and dose-response evidence from EDLists, SIN List, and cosmetic-specific detail sources.
Cosmetic-Specific Mechanism
Category: UV filter
Receptor targets: ERα
LOEC: 1 µM
EU status: allowed (as UV stabilizer)
agonist
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
KR Korea MFDS Annex 2 (Restricted)
Category: UV Filter. Max: 1.0%.
JPKR Japan/Korea Cosmetics
Japan (Restricted): max 7.0
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Fragrance
Stabilizing agent
UV stabilizer
Regulatory List Membership (2)
IFRA Fragrance Transparency List
FDA Indirect Food Contact Additives
Expert Verdict
Expert safety assessment and concern-level summary for Drometrizole.
Regulatory Flags
fragrance-component
ifra_fragrance
Known Synonyms
2-(2H-Benzotriazol-2-yl)-p-cresol
Phenol, 2-(2H-benzotriazol-2-yl)-4-methyl-
BRN 0615546
EINECS 219-470-5
Porex P
UV absorber-1
Drometrizol
Drometrizolum
UNII-5X93W9OFZL
Chemical Function
UV stabilizer
Stabilizing agent
Fragrance
Regulatory Lists
CEDI
Indirect additives food contact (10/2018)
drinking_water; Europe; manufacturing; plastic_additive
inert_ingredient; non_food_use; Pesticides
Europe; plastic_additive
detected; Europe; Other indirect contact consumer goods
detected; emissions; Europe; Other indirect contact consumer goods; water
pharmaceutical
IFRA Transparency
artificial_sweat; detected; emissions; Europe; Toys and children's products
artificial_sweat; detected; emissions; Europe; Toys and children's products
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
DROMETRIZOLE
ChEMBL ID
CHEMBL1564747
Max Phase
3
Frequently Asked Questions
Is Drometrizole allowed in the EU?
Drometrizole EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Drometrizole do in cosmetics?
Drometrizole functions as: UV absorber; fragrance functional. It is classified as a cosmetic ingredient in our database. CAS number: 2440-22-4.
Is Drometrizole used outside cosmetics?
Drometrizole also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Drometrizole compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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