NOAEL Data Cosmetic Ingredient

2-Methylbutyl isovalerate

Also known as: Butanoic acid, 3-methyl-, 2-methylbutyl ester, EINECS 219-496-7, FEMA No. 3506, Isovaleric acid, 2-methylbutyl ester, 2-Methylbutyl isopentanoate (+3 more)

CAS 2445-77-4

2-Methylbutyl isovalerate (CAS 2445-77-4) is a chemical substance. Key regulatory status: 5 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.

View cosmetic safety profile for 2-Methylbutyl Isovalerate →

SOURCE NOAEL studies
NOAEL studies
18
SOURCE Chemical inventory jurisdictions
Regulatory lists
5
SOURCE EU CLP Annex VI
GHS signal
Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 13 fields
Name
2-Methylbutyl isovalerate
CAS Number
2445-77-4
Molecular Formula
C10H20O2
InChI Key
CYGPPWVXOWCHJB-UHFFFAOYSA-N
Monoisotopic Mass
172.14633
Synonyms
Butanoic acid, 3-methyl-, 2-methylbutyl esterEINECS 219-496-7FEMA No. 3506Isovaleric acid, 2-methylbutyl ester2-Methylbutyl isopentanoate2-Methylbutyl isovalerianate2-Methylbutyl 3-methylbutanoateUNII-7G5TZ5034W

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 5 records
FragranceFlavouring and nutrient

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 5 records
ListKeywordSource
IFRA TransparencyIFRAIFRA
consumer_productP&GProctor & Gamble
EuropeEuropean CommissionFl@vis
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)FDAUnited States Food and Drug Administration (FDA)
inert_ingredient; non_food_use; PesticidesEPACPCat

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 18 of 18 studies
ValueUnitEndpointRouteSpeciesSource
7G5TZ5034WUNIIFDA UNII substance identifier--openFDA substances
0unitlessModel Score--NTP ICE endocrine
=50mg/kg bw/dayNOAELoralRatEFSA
=50mg/kg bw/dayNOAELoral: gavageRatEFSA
=125mg/kg bw/dayNOAELoralRatEFSA
=125mg/kg bw/dayNOAELoral: gavageRatEFSA
>219mg/kg bw/dayNOAELoralRatEFSA
>219mg/kg bw/dayNOAELoral: unspecifiedRatEFSA
>300mg/kg bw/dayNOAELoralRatEFSA
>300mg/kg bw/dayNOAELoral: feedRatEFSA
=340mg/kg bw/dayNOAELoralRatEFSA
=340mg/kg bw/dayNOAELoral: drinking waterRatEFSA
>1000mg/kg bw/dayNOAELoralRatEFSA
>1000mg/kg bw/dayNOAELoral: gavageRatEFSA
>1450mg/kg bw/dayNOAELoralRatEFSA
>1450mg/kg bw/dayNOAELoral: drinking waterRatEFSA
>2500mg/kg bw/dayNOAELoralRatEFSA
>2500mg/kg bw/dayNOAELoral: feedRatEFSA

Showing 18 of 18 studies

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE ChEMBL / DailyMed CHEMBL3182254
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
View full pharmaceutical profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA 1 records

1 food-safety record found.

View full food safety profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the NOAEL for 2-Methylbutyl isovalerate?

2-Methylbutyl isovalerate has 18 NOAEL studies in the database. The lowest reported value is 7G5TZ5034W UNII. Source: openFDA substances.

What regulatory lists include 2-Methylbutyl isovalerate?

2-Methylbutyl isovalerate appears on 5 regulatory/inventory lists including IFRA Transparency, consumer_product, Europe, and 2 more. Source: EPA CPDat.

Is 2-Methylbutyl isovalerate used in cosmetics?

Yes, 2-Methylbutyl isovalerate is also indexed as a cosmetic ingredient under the name 2-Methylbutyl Isovalerate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 2-Methylbutyl isovalerate come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Is 2-Methylbutyl isovalerate used outside industrial chemicals?

2-Methylbutyl isovalerate also appears in cosmetics, pharmaceutical, food safety, cannabis databases.