Is 2-Methylbutyl Isovalerate safe in cosmetics?
2-Methylbutyl Isovalerate has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
GOOD
Cosmetic Ingredient
2-Methylbutyl Isovalerate
Also known as: Butanoic acid, 3-methyl-, 2-methylbutyl ester, EINECS 219-496-7, FEMA No. 3506, Isovaleric acid, 2-methylbutyl ester, 2-Methylbutyl isopentanoate (+3 more)
INCI: 2-METHYLBUTYL ISOVALERATE
2-Methylbutyl Isovalerate (CAS 2445-77-4) is a cosmetic cosmetic ingredient functioning as Fragrance ingredient. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
Function
Fragrance ingredient
Editorial assessment
GOOD
Preliminary editorial note — not a computed safety verdict.
Chemistry & Identifiers
IUPAC Name
2-methylbutyl 3-methylbutanoate
InChIKey
CYGPPWVXOWCHJB-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — FEMA GRAS for flavor; no FDA restriction for cosmetics
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for 2-Methylbutyl Isovalerate.
Calculate MoS for your specific formulation with the MoS Calculator.
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (2)
JECFA Number
204
Source: WHO/JECFA
JECFA Evaluation
2-METHYLBUTYL 3-METHYLBUTANOATE | 1997 | No safety concern at current levels of intake when used as a flavouring agent | TRS 884-JECFA 49/52 | FAS 40-JECFA 49/267
Source: WHO/JECFA
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Editorial summary
Preliminary editorial summary for 2-Methylbutyl Isovalerate — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
fragrance-component
ifra_fragrance
fda_food_additive
Known Synonyms
Butanoic acid, 3-methyl-, 2-methylbutyl ester
EINECS 219-496-7
FEMA No. 3506
Isovaleric acid, 2-methylbutyl ester
2-Methylbutyl isopentanoate
2-Methylbutyl isovalerianate
2-Methylbutyl 3-methylbutanoate
UNII-7G5TZ5034W
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
IFRA Transparency
consumer_product
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
inert_ingredient; non_food_use; Pesticides
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3182254
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
2-METHYLBUTYL ISOVALERATE
Food Category
flavoring
Frequently Asked Questions
Is 2-Methylbutyl Isovalerate allowed in the EU?
2-Methylbutyl Isovalerate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does 2-Methylbutyl Isovalerate do in cosmetics?
2-Methylbutyl Isovalerate functions as: Fragrance ingredient. It is classified as a cosmetic ingredient in our database. CAS number: 2445-77-4.
Is 2-Methylbutyl Isovalerate used outside cosmetics?
2-Methylbutyl Isovalerate also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check 2-Methylbutyl Isovalerate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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