Is 2-Methylbutyl Isovalerate safe in cosmetics?
2-Methylbutyl Isovalerate has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
2-Methylbutyl Isovalerate
Also known as: Butanoic acid, 3-methyl-, 2-methylbutyl ester, EINECS 219-496-7, FEMA No. 3506, Isovaleric acid, 2-methylbutyl ester, 2-Methylbutyl isopentanoate (+3 more)
INCI: 2-METHYLBUTYL ISOVALERATE
2-Methylbutyl Isovalerate (CAS 2445-77-4) is a cosmetic cosmetic ingredient functioning as Fragrance ingredient. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 2445-77-4 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance ingredient
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
2-methylbutyl 3-methylbutanoate
InChIKey
CYGPPWVXOWCHJB-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — FEMA GRAS for flavor; no FDA restriction for cosmetics
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for 2-Methylbutyl Isovalerate.
Calculate MoS for your specific formulation with the MoS Calculator.
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (2)
JECFA Number
204
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
2-METHYLBUTYL 3-METHYLBUTANOATE | 1997 | No safety concern at current levels of intake when used as a flavouring agent | TRS 884-JECFA 49/52 | FAS 40-JECFA 49/267
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for 2-Methylbutyl Isovalerate.
Regulatory Flags
fragrance-component
ifra_fragrance
fda_food_additive
Known Synonyms
Butanoic acid, 3-methyl-, 2-methylbutyl ester
EINECS 219-496-7
FEMA No. 3506
Isovaleric acid, 2-methylbutyl ester
2-Methylbutyl isopentanoate
2-Methylbutyl isovalerianate
2-Methylbutyl 3-methylbutanoate
UNII-7G5TZ5034W
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
IFRA Transparency
consumer_product
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
inert_ingredient; non_food_use; Pesticides
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3182254
Frequently Asked Questions
Is 2-Methylbutyl Isovalerate allowed in the EU?
2-Methylbutyl Isovalerate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does 2-Methylbutyl Isovalerate do in cosmetics?
2-Methylbutyl Isovalerate functions as: Fragrance ingredient. It is classified as a cosmetic ingredient in our database. CAS number: 2445-77-4.
Is 2-Methylbutyl Isovalerate used outside cosmetics?
2-Methylbutyl Isovalerate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check 2-Methylbutyl Isovalerate compliance across multiple jurisdictions:
Ingredient Decoder
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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