What is the NOAEL for 2-Isobutyl-3-methoxypyrazine?
2-Isobutyl-3-methoxypyrazine has 7 NOAEL studies in the database. The lowest reported value is S327O0T12O UNII. Source: openFDA substances.
NOAEL Data
Cosmetic Ingredient
2-Isobutyl-3-methoxypyrazine
Also known as: Pyrazine, 2-methoxy-3-(2-methylpropyl)-, EINECS 246-402-1, FEMA No. 3132, 3-Isobutyl-2-methoxypyrazine, 2-Methoxy-3-isobutylpyrazine (+3 more)
CAS 24683-00-9
2-Isobutyl-3-methoxypyrazine (CAS 24683-00-9) is a chemical substance. Key regulatory status: 5 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.
SOURCE
noael studies public
NOAEL studies
7
SOURCE
chemical inventory jurisdictions
Regulatory lists
5
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
14 fields
Name
2-Isobutyl-3-methoxypyrazine
CAS Number
24683-00-9
DTXSID
DTXSID9051907
Molecular Formula
C9H14N2O
InChI Key
UXFSPRAGHGMRSQ-UHFFFAOYSA-N
Monoisotopic Mass
166.110613
Synonyms
Pyrazine, 2-methoxy-3-(2-methylpropyl)-EINECS 246-402-1FEMA No. 31323-Isobutyl-2-methoxypyrazine2-Methoxy-3-isobutylpyrazine2-Methoxy-3-(2-methylpropyl)pyrazinePyrazine, 2-isobutyl-3-methoxy-UNII-S327O0T12O
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
5 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
5 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| Canada; pharmaceutical | DrugBank | DrugBank |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 7 of 7 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| S327O0T12O | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| S327O0T12O | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| S327O0T12O | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| S327O0T12O | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 13.5 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 7 of 7 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL97355
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include 2-Isobutyl-3-methoxypyrazine?
2-Isobutyl-3-methoxypyrazine appears on 5 regulatory/inventory lists including IFRA Transparency, Europe, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), and 2 more. Source: EPA CPDat.
Is 2-Isobutyl-3-methoxypyrazine used in cosmetics?
Yes, 2-Isobutyl-3-methoxypyrazine is also indexed as a cosmetic ingredient under the name Isobutyl-Methoxypyrazine. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 2-Isobutyl-3-methoxypyrazine come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is 2-Isobutyl-3-methoxypyrazine used outside industrial chemicals?
2-Isobutyl-3-methoxypyrazine also appears in cosmetics, pharmaceutical, food safety, cannabis databases.