Isobutyl-Methoxypyrazine

INCI: ISOBUTYL-METHOXYPYRAZINE (ALSO KNOWN AS 2-ISOBUTYL-3-METHOXYPYRAZINE)

CAS Number
24683-00-9
Function
Fragrance
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Allowed in cosmetics; GRAS as food flavoring (FEMA 3132)

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

GHS classification - Eye Irritant Cat. 2, Skin Irritant Cat. 2, STOT SE Cat. 3 (respiratory irritation); RIFM safety assessment conducted; follows IFRA guidelines. Extremely potent green bell pepper-like aroma detectable at parts-per-trillion concentrations; naturally found in green bell peppers, wine grapes, and coffee; pyrazine heterocyclic structure

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Concern Level: Moderate

Regulatory Flags

fragrance-component ifra_fragrance fda_food_additive

Frequently Asked Questions

Is Isobutyl-Methoxypyrazine safe in cosmetics?

GHS classification - Eye Irritant Cat. 2, Skin Irritant Cat. 2, STOT SE Cat. 3 (respiratory irritation); RIFM safety assessment conducted; follows IFRA guidelines. Extremely potent green bell pepper-like aroma detectable at parts-per-trillion concentrations; naturally found in green bell peppers, wine grapes, and coffee; pyrazine heterocyclic structure The EU classifies Isobutyl-Methoxypyrazine as "permitted". Safety rating: MODERATE.

Is Isobutyl-Methoxypyrazine allowed in the EU?

Isobutyl-Methoxypyrazine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Isobutyl-Methoxypyrazine do in cosmetics?

Isobutyl-Methoxypyrazine functions as: Fragrance. It is classified as a cosmetic ingredient in our database. CAS number: 24683-00-9.

What is the Margin of Safety for Isobutyl-Methoxypyrazine?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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