Is Isobutyl-Methoxypyrazine safe in cosmetics?
Isobutyl-Methoxypyrazine has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Isobutyl-Methoxypyrazine
Also known as: Pyrazine, 2-methoxy-3-(2-methylpropyl)-, EINECS 246-402-1, FEMA No. 3132, 3-Isobutyl-2-methoxypyrazine, 2-Methoxy-3-isobutylpyrazine (+3 more)
INCI: ISOBUTYL-METHOXYPYRAZINE (ALSO KNOWN AS 2-ISOBUTYL-3-METHOXYPYRAZINE)
Isobutyl-Methoxypyrazine (CAS 24683-00-9) is a cosmetic cosmetic ingredient functioning as Fragrance. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
View industrial chemical safety profile for CAS 24683-00-9 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
2-methoxy-3-(2-methylpropyl)pyrazine
InChIKey
UXFSPRAGHGMRSQ-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Allowed in cosmetics; GRAS as food flavoring (FEMA 3132)
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Isobutyl-Methoxypyrazine.
Calculate MoS for your specific formulation with the MoS Calculator.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 13.5 | - | - |
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (3)
JECFA Number
792
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
2-ISOBUTYL-3-METHOXYPYRAZINE | 2001 | No safety concern at current levels of intake when used as a flavouring agent | TRS 909-JECFA 57/51 | FAS 48-JECFA 57/135
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
2-METHOXY-3-ISOBUTYLPYRAZINE | 2001 | No safety concern at current levels of intake when used as a flavouring agent | TRS 909-JECFA 57/51 | FAS 48-JECFA 57/135
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Isobutyl-Methoxypyrazine.
Regulatory Flags
fragrance-component
ifra_fragrance
fda_food_additive
Known Synonyms
Pyrazine, 2-methoxy-3-(2-methylpropyl)-
EINECS 246-402-1
FEMA No. 3132
3-Isobutyl-2-methoxypyrazine
2-Methoxy-3-isobutylpyrazine
2-Methoxy-3-(2-methylpropyl)pyrazine
Pyrazine, 2-isobutyl-3-methoxy-
UNII-S327O0T12O
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
IFRA Transparency
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Canada; pharmaceutical
consumer_product
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL97355
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
2-ISOBUTYL-3-METHOXYPYRAZINE
ADI
No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
Food Category
flavoring
Frequently Asked Questions
Is Isobutyl-Methoxypyrazine allowed in the EU?
Isobutyl-Methoxypyrazine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Isobutyl-Methoxypyrazine do in cosmetics?
Isobutyl-Methoxypyrazine functions as: Fragrance. It is classified as a cosmetic ingredient in our database. CAS number: 24683-00-9.
Is Isobutyl-Methoxypyrazine used outside cosmetics?
Isobutyl-Methoxypyrazine also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Isobutyl-Methoxypyrazine compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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