NOAEL Data Cosmetic Ingredient

2-(4-Amino-3-nitroanilino)ethanol

Also known as: HC Red 7, EINECS 246-521-9, UNII-5WRI22G12X

CAS 24905-87-1

2-(4-Amino-3-nitroanilino)ethanol (CAS 24905-87-1) is a chemical substance. Key regulatory status: 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.

View cosmetic safety profile for HC Red No. 7 →

Cross-Vertical Regulatory Divergence

2-(4-Amino-3-nitroanilino)ethanol is prohibited in EU cosmetics but has active industrial GHS classifications (H317, H302, H315, H319, H335).

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 9 fields

Name

2-(4-Amino-3-nitroanilino)ethanol

CAS Number

24905-87-1

DTXSID

DTXSID90179613

Molecular Formula

C8H11N3O3

InChI Key

DAGCJJZWDAVKRE-UHFFFAOYSA-N

Monoisotopic Mass

197.080041

Synonyms

HC Red 7EINECS 246-521-9UNII-5WRI22G12X

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 2 records

Dye

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 4 records

List	Keyword	Source
Europe; Personal care; restricted	European Commission	CosIng
Canada; Personal care; Substances in PCP - Canada (4/2014)	Government of Canada	CPCat
children; Europe; Personal care	Danish Environmental Protection Agency	Danish EPA
children; Europe; Personal care	Danish Environmental Protection Agency	Danish EPA

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 33 of 33 studies

Value	Unit	Endpoint	Route	Species	Source
10	%	-	oral	rat	UnifiedCodex:SCCNFP:beta.noael_studies
50	mg/kg bw/day	-	-	-	UnifiedCodex:SCCNFP:beta.noael_studies
50	mg/kg bw/day	-	-	rat	UnifiedCodex:SCCNFP:beta.noael_studies
50	mg/kg bw/day	-	-	-	UnifiedCodex:SCCNFP:beta.noael_studies
200	mg/kg bw/day	-	-	-	UnifiedCodex:SCCNFP:beta.noael_studies
5WRI22G12X	UNII	FDA UNII substance identifier	-	-	openFDA substances
5WRI22G12X	UNII	FDA UNII substance identifier	-	-	openFDA substances
5WRI22G12X	UNII	FDA UNII substance identifier	-	-	openFDA substances
5WRI22G12X	UNII	FDA UNII substance identifier	-	-	openFDA substances
50	mg/kg bw/day	LOAEL	oral	rat	COSMOS_DB
=10	%	NOAEL	oral	rat	SCCNFP_vision_codex
=10	%	NOAEL	oral	rat	SCCNFP_vision_codex
=10	%	NOAEL	oral	rat	SCCNFP_vision_codex
=10	%	NOAEL	oral	rat	SCCNFP_vision_codex
=50	mg/kg day	NOAEL	oral	rat	CIR_vision_codex
=50	mg/kg bw/day	NOAEL	dermal	rat	SCCNFP_vision_codex
=50	mg/kg day	NOAEL	oral	rat	CIR_vision_codex
=50	mg/kg day	NOAEL	oral	rat	CIR_vision_codex
=50	mg/kg day	NOAEL	oral	rat	CIR_vision_codex
=50	mg/kg bw/day	NOAEL	dermal	rat	SCCNFP_vision_codex
=50	mg/kg bw/day	NOAEL	dermal	rat	SCCNFP_vision_codex
=50	mg/kg bw/day	NOAEL	dermal	rat	SCCNFP_vision_codex
=200	mg/kg/day	NOAEL	oral	rat	CIR_vision_codex
=200	mg/kg bw/day	NOAEL	-	-	SCCNFP_vision_codex
=200	mg/kg/day	NOAEL	oral	rat	CIR_vision_codex
=200	mg/kg/day	NOAEL	oral	rat	CIR_vision_codex
=200	mg/kg/day	NOAEL	oral	rat	CIR_vision_codex
=200	mg/kg bw/day	NOAEL	-	-	SCCNFP_vision_codex
=200	mg/kg bw/day	NOAEL	-	-	SCCNFP_vision_codex
=200	mg/kg bw/day	NOAEL	-	-	SCCNFP_vision_codex
50	mg/kg day	repeated dose toxicity	oral	rat	UnifiedCodex:CIR:beta.noael_studies
50	mg/kg bw/day	repeated dose toxicity	dermal	rat	UnifiedCodex:SCCNFP:beta.noael_studies
200	mg/kg/day	repeated dose toxicity	oral	rat	UnifiedCodex:CIR:beta.noael_studies

Showing 33 of 33 studies

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

prohibited

Max

Frequently Asked Questions

What is the NOAEL for 2-(4-Amino-3-nitroanilino)ethanol?

2-(4-Amino-3-nitroanilino)ethanol has 33 NOAEL studies in the database. The lowest reported value is 10 % via oral in rat. Source: UnifiedCodex:SCCNFP:beta.noael_studies.

What regulatory lists include 2-(4-Amino-3-nitroanilino)ethanol?

2-(4-Amino-3-nitroanilino)ethanol appears on 3 regulatory/inventory lists including Europe; Personal care; restricted, Canada; Personal care; Substances in PCP - Canada (4/2014), children; Europe; Personal care. Source: EPA CPDat.

Is 2-(4-Amino-3-nitroanilino)ethanol used in cosmetics?

Yes, 2-(4-Amino-3-nitroanilino)ethanol is also indexed as a cosmetic ingredient under the name HC Red No. 7. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 2-(4-Amino-3-nitroanilino)ethanol come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.

Does 2-(4-Amino-3-nitroanilino)ethanol have different safety status in cosmetics vs industrial chemicals?

2-(4-Amino-3-nitroanilino)ethanol is prohibited in EU cosmetics but has active industrial GHS classifications (H317, H302, H315, H319, H335).

Is 2-(4-Amino-3-nitroanilino)ethanol used outside industrial chemicals?

2-(4-Amino-3-nitroanilino)ethanol also appears in cosmetics databases.