Is HC Red No. 7 safe in cosmetics?
HC Red No. 7 has a safety rating of "GOOD" in our database. EU status: prohibited. US status: permitted. 10 toxicological study endpoint(s) are available in our database. This ingredient has been reviewed by cir.
HC Red No. 7
Also known as: HC Red 7, EINECS 246-521-9, UNII-5WRI22G12X
INCI: HC RED NO. 7
HC Red No. 7 (CAS 24905-87-1) is a cosmetic cosmetic ingredient functioning as Semi-permanent (direct) hair colorant. Reported NOAEL =50 mg/kg day in rat (CIR_vision_codex); EU Regulation 1223/2009 status: prohibited; 3 safety opinions reviewed (cir). Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 24905-87-1 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
HC Red No. 7 is prohibited in EU cosmetics but has active industrial GHS classifications (H317, H302, H315, H319, H335).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Semi-permanent (direct) hair colorant
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
2-(4-amino-3-nitroanilino)ethanol
InChIKey
DAGCJJZWDAVKRE-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
Permitted under coal tar hair dye exemption (FD&C Act 601(a)). CIR: safe as used at ≤1%.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for HC Red No. 7.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for HC Red No. 7. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =50 mg/kg day | oral | rat | repeated dose toxicity | CIR_vision_codex |
| NOAEL | =50 mg/kg day | oral | rat | repeated dose toxicity | CIR_vision_codex |
| NOAEL | =50 mg/kg day | oral | rat | repeated dose toxicity | CIR_vision_codex |
| NOAEL | =50 mg/kg day | oral | rat | repeated dose toxicity | CIR_vision_codex |
| NOAEL | =200 mg/kg/day | oral | rat | repeated dose toxicity | CIR_vision_codex |
| NOAEL | =200 mg/kg/day | oral | rat | repeated dose toxicity | CIR_vision_codex |
| NOAEL | =200 mg/kg/day | oral | rat | repeated dose toxicity | CIR_vision_codex |
| NOAEL | =200 mg/kg/day | oral | rat | repeated dose toxicity | CIR_vision_codex |
| NOAEL | =50 mg/kg bw/day | dermal | rat | repeated dose toxicity | SCCNFP_vision_codex |
| NOAEL | =50 mg/kg bw/day | dermal | rat | repeated dose toxicity | SCCNFP_vision_codex |
Safety Opinions
Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).
cir
Verdict: unknown
NOAEL: 200 mg/kg/day (not specified)
cir
Verdict: unknown
NOAEL: 50 mg/kg/day (not specified)
cir
Verdict: unknown
NOAEL: 50 mg/kg/day (oral)
Sensitization Profile
Contact sensitization data for HC Red No. 7 based on clinical patch test studies and IFRA standards.
Sensitization Rate
low
Allergen Class
dye
EU Allergen Listed
no
Patch Test Positive Rate
0.2%
Cross-reactivity Group
para-amino-group
Reaction Type
contact-dermatitis
Source: SCCS; IVDK
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (III - Restricted)
Product type: Hair dye substance in non-oxidative hair dye products. Max: 1,0%.
BRIN Brazil/India Cosmetics
India: Restricted · max 1,0%
Additional Jurisdictional Restrictions (2)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| CN | permitted_hair_dye | 1 | Non-oxidative hair dye |
| BR | permitted_hair_dye | - | Direct hair dye |
Additional Ingredient Properties
2 property records from structured ingredient metadata.
allergen_detail
{"eu_allergen_listed": "no", "allergen_class": "dye", "cross_reactivity_group": "para-amino-group", "patch_test_frequency_pct": "0.2", "sensitization_rate": "low", "common_reaction_type": "contact-dermatitis", "ifra_restricted": "no", "source": "SCCS; IVDK"}
hair_dye
{"cas_number": "24905-87-1", "ingredient_class": "direct_dye", "chemical_class": "nitro", "molecular_weight_Da": "168.15", "color_result_on_hair": "Red", "shade_range": "red", "primary_function": "direct_deposit", "requires_developer": "no", "lift_capability_levels": "0", "deposit_only": "yes", "permanence": "semi_permanent", "wash_fastness_shampoos": "6-12", "light_fastness": "moderate", "heat_st…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Regulatory List Membership (2)
EU Restricted for Children (Cosmetics)
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for HC Red No. 7.
Regulatory Flags
colorant
eu_children_restricted
eu_cosing_listed
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to HC Red No. 7 by CAS number or substance name.
Studies
16
Lowest NOAEL
50
Highest NOAEL
200
Units vary across source rows: mg/kg day, mg/kg/day, mg/kg bw/day
CIR_vision_codex
SCCNFP_vision_codex
Known Synonyms
HC Red 7
EINECS 246-521-9
UNII-5WRI22G12X
Chemical Function
Dye
Regulatory Lists
Europe; Personal care; restricted
Canada; Personal care; Substances in PCP - Canada (4/2014)
children; Europe; Personal care
children; Europe; Personal care
Australian Status
AICIS status: listed
Frequently Asked Questions
Is HC Red No. 7 allowed in the EU?
HC Red No. 7 EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does HC Red No. 7 do in cosmetics?
HC Red No. 7 functions as: Semi-permanent (direct) hair colorant. It is classified as a cosmetic ingredient in our database. CAS number: 24905-87-1.
What is the NOAEL for HC Red No. 7?
The NOAEL (No Observed Adverse Effect Level) for HC Red No. 7 is =50 mg/kg day based on a repeated dose toxicity study via oral route in rat. A total of 10 study endpoints are available. Source: CIR_vision_codex.
Is HC Red No. 7 used outside cosmetics?
HC Red No. 7 also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does HC Red No. 7 have different safety status in cosmetics vs industrial chemicals?
HC Red No. 7 is prohibited in EU cosmetics but has active industrial GHS classifications (H317, H302, H315, H319, H335).
Compliance Tools
Check HC Red No. 7 compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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