Good Cosmetic Ingredient NOAEL Data SCCS/CIR Reviewed Sensitization Data

HC Red No. 7

INCI: HC RED NO. 7

CAS Number
24905-87-1
Function
Semi-permanent (direct) hair colorant
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status prohibited
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted under coal tar hair dye exemption (FD&C Act 601(a)). CIR: safe as used at โ‰ค1%.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

1 study endpoint found for HC Red No. 7. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
LOAEL 50 mg/kg bw/day oral rat Subchronic COSMOS_DB

Safety Opinions

Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).

cir
Verdict: unknown
NOAEL: 200 mg/kg/day (not specified)
cir
Verdict: unknown
NOAEL: 50 mg/kg/day (not specified)
cir
Verdict: unknown
NOAEL: 50 mg/kg/day (oral)

Sensitization Profile

Contact sensitization data for HC Red No. 7 based on clinical patch test studies and IFRA standards.

Sensitization Rate
low
Allergen Class
dye
EU Allergen Listed
no
Patch Test Positive Rate
0.2%
Cross-reactivity Group
para-amino-group
Reaction Type
contact-dermatitis

Source: SCCS; IVDK

Expert Verdict

Mutagenicity studies gave mixed results; CIR concluded it is at most a weak mutagen. Low dermal absorption mitigates genotoxicity risk. Purity >98.5%.

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Concern Level: High

Regulatory Flags

colorant eu_children_restricted eu_cosing_listed

Frequently Asked Questions

Is HC Red No. 7 safe in cosmetics?

Mutagenicity studies gave mixed results; CIR concluded it is at most a weak mutagen. Low dermal absorption mitigates genotoxicity risk. Purity >98.5%. The EU classifies HC Red No. 7 as "prohibited". Safety rating: GOOD. 1 toxicological study endpoint(s) are available in our database. This ingredient has been reviewed by cir.

Is HC Red No. 7 allowed in the EU?

HC Red No. 7 EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does HC Red No. 7 do in cosmetics?

HC Red No. 7 functions as: Semi-permanent (direct) hair colorant. It is classified as a cosmetic ingredient in our database. CAS number: 24905-87-1.

What is the Margin of Safety for HC Red No. 7?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for HC Red No. 7?

The NOAEL (No Observed Adverse Effect Level) for HC Red No. 7 is 50 mg/kg bw/day based on a Subchronic study via oral route in rat. Source: COSMOS_DB.

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