Also known as: Propanoic acid, 2-methyl-, monoester with 2,2,4-trimethyl-1,3-pentanediol, 2,2,4-Trimethyl-1,3-neopentyl glycol monoisobutyrate, 2,2,4-Trimethyl-1,3-pentanediol mono(2-methylpropanoate), 2,2,4-Trimethyl-1,3-pentanediol monoisobutylate, 3-Pentanediol,2,2,4-trimethyl-monoisobutyrate (+12 more)
CAS 25265-77-4
2,2,4-Trimethyl-1,3-pentanediol monoisobutyrate (CAS 25265-77-4) is a chemical substance. Key regulatory status: REACH registered, 5 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.
View cosmetic safety profile for Trimethyl Hydroxypentyl Isobutyrate →
CAS, identifiers, formula, and alternate names for the matched substance record.
International Chemical Safety Card hazard and exposure summary.
| Field | Value |
|---|---|
| Short-term Effects | The substance is irritating to the eyes and skin. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation of its aerosol and by ingestion. |
Industrial and product-use categories associated with this substance.
Inventory, screening, and regulatory list matches from public chemical databases.
| List | Keyword | Source |
|---|---|---|
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| Europe; plastic_additive | European Chemicals Agency | European Chemicals Agency (ECHA) |
| IFRA Transparency | IFRA | IFRA |
| air; Cons electronics mech appliances and machinery; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =123.4 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB GESTIS DNEL |
| ID6ZZH846Y | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =3200 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =2.754e+4 | mg/m3 | LEL | inhalation | Human | ToxValDB DOE Protective Action Criteria |
| =300 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| =1000 | mg/kg bw/day | NOAEL | oral | Rabbit | ECHA |
| =1.336 | mg/m3 | NOAEL (ADJ) | oral | Rat | ToxValDB TX TCEQ |
| =1035 | mg/m3 | NOAEL (ADJ) | inhalation | Rat | ToxValDB TX TCEQ |
| >15 | mg/kg bw/day | NOEL | oral | Rat | ECHA |
| >150 | mg/kg bw/day | NOEL | oral | Rat | ECHA |
Showing 10 of 10 studies
Registration status from the ECHA REACH registered substances database.
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Isobutyric acid, monoester with 2,2,4-trimethylpentane-1,3-diol | 246-771-9 | ECHA overview → |
Australian industrial chemicals inventory status and applicable conditions.
Same-CAS cosmetic ingredient record for cross-vertical context.
2,2,4-Trimethyl-1,3-pentanediol monoisobutyrate has 10 NOAEL studies in the database. The lowest reported value is 123.4 mg/m3 via inhalation in Human. Source: ToxValDB GESTIS DNEL.
2,2,4-Trimethyl-1,3-pentanediol monoisobutyrate appears on 5 regulatory/inventory lists including inert_ingredient; non_food_use; Pesticides, Europe; plastic_additive, IFRA Transparency, and 2 more. Source: EPA CPDat.
Yes, 2,2,4-Trimethyl-1,3-pentanediol monoisobutyrate is also indexed as a cosmetic ingredient under the name Trimethyl Hydroxypentyl Isobutyrate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.
2,2,4-Trimethyl-1,3-pentanediol monoisobutyrate also appears in cosmetics databases.