Moderate Cosmetic Ingredient GHS Classified

Trimethyl Hydroxypentyl Isobutyrate

INCI: TRIMETHYL HYDROXYPENTYL ISOBUTYRATE

CAS Number
25265-77-4
Function
Plasticiser (softens brittle materials in formulations)
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Listed in FDA substance registry; no specific restriction under current cosmetic regulations

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Short-term Exposure Effects
The substance is irritating to the eyes and skin.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its aerosol and by ingestion.

Expert Verdict

Primary use is industrial (paint coalescent), not cosmetic; limited human safety data for dermal cosmetic application; verify supplier grade is cosmetic-appropriate

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Concern Level: Moderate

Regulatory Flags

epa_safer_alternative ifra_fragrance

Frequently Asked Questions

Is Trimethyl Hydroxypentyl Isobutyrate safe in cosmetics?

Primary use is industrial (paint coalescent), not cosmetic; limited human safety data for dermal cosmetic application; verify supplier grade is cosmetic-appropriate The EU classifies Trimethyl Hydroxypentyl Isobutyrate as "permitted". Safety rating: MODERATE.

Is Trimethyl Hydroxypentyl Isobutyrate allowed in the EU?

Trimethyl Hydroxypentyl Isobutyrate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Trimethyl Hydroxypentyl Isobutyrate do in cosmetics?

Trimethyl Hydroxypentyl Isobutyrate functions as: Plasticiser (softens brittle materials in formulations). It is classified as a cosmetic ingredient in our database. CAS number: 25265-77-4.

What is the Margin of Safety for Trimethyl Hydroxypentyl Isobutyrate?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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Is Trimethyl Hydroxypentyl Isobutyrate in Your Products?

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