Also known as: Propanoic acid, 2-methyl-, monoester with 2,2,4-trimethyl-1,3-pentanediol, 2,2,4-Trimethyl-1,3-neopentyl glycol monoisobutyrate, 2,2,4-Trimethyl-1,3-pentanediol mono(2-methylpropanoate), 2,2,4-Trimethyl-1,3-pentanediol monoisobutylate, 3-Pentanediol,2,2,4-trimethyl-monoisobutyrate (+13 more)
INCI: TRIMETHYL HYDROXYPENTYL ISOBUTYRATE
Trimethyl Hydroxypentyl Isobutyrate (CAS 25265-77-4) is a cosmetic cosmetic ingredient functioning as Plasticiser (softens brittle materials in formulations). Reported NOAEL =300 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
US NotesListed in FDA substance registry; no specific restriction under current cosmetic regulations
For full compliance data across multiple jurisdictions, use the
Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Trimethyl Hydroxypentyl Isobutyrate.
Calculate MoS for your specific formulation with the
MoS Calculator.
Toxicological Studies
1 study endpoint found for Trimethyl Hydroxypentyl Isobutyrate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
Endpoint
Value
Route
Species
Study Type
Source
NOAEL
=300 mg/kg bw/day
oral
Rat
subchronic
ToxValDB_ECHA_IUCLID
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Short-term Exposure Effects
The substance is irritating to the eyes and skin.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its aerosol and by ingestion.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10,000 - 100,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
ICSC Safety Card
0629
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
BinderCoalescing agentDiluentFilm formerFragranceNo specific technical functionPlasticizerProcessing aids not otherwise specifiedSolventSurfactant (surface active agent)
Regulatory List Membership (2)
IFRA Fragrance Transparency ListEPA Safer Chemical Ingredients List (SCIL)
Expert Verdict
Expert safety assessment and concern-level summary for Trimethyl Hydroxypentyl Isobutyrate.
Is Trimethyl Hydroxypentyl Isobutyrate safe in cosmetics?
Trimethyl Hydroxypentyl Isobutyrate has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted. 1 toxicological study endpoint(s) are available in our database.
Is Trimethyl Hydroxypentyl Isobutyrate allowed in the EU?
Trimethyl Hydroxypentyl Isobutyrate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Trimethyl Hydroxypentyl Isobutyrate do in cosmetics?
Trimethyl Hydroxypentyl Isobutyrate functions as: Plasticiser (softens brittle materials in formulations). It is classified as a cosmetic ingredient in our database. CAS number: 25265-77-4.
What is the NOAEL for Trimethyl Hydroxypentyl Isobutyrate?
The NOAEL (No Observed Adverse Effect Level) for Trimethyl Hydroxypentyl Isobutyrate is =300 mg/kg bw/day based on a subchronic study via oral route in Rat. Source: ToxValDB_ECHA_IUCLID.
Is Trimethyl Hydroxypentyl Isobutyrate used outside cosmetics?
Trimethyl Hydroxypentyl Isobutyrate also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Trimethyl Hydroxypentyl Isobutyrate compliance across multiple jurisdictions:
Is Trimethyl Hydroxypentyl Isobutyrate in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Trimethyl Hydroxypentyl Isobutyrate in your formulation.