NOAEL Data Cosmetic Ingredient

(E,Z,E)-N-(2-Methylpropyl)-2,6,8-decatrienamide

Also known as: 2,6,8-Decatrienamide, N-isobutyl-, (E,Z,E)-, Spilanthol, N-Isobutyl-2E-decenamide

CAS 25394-57-4

(E,Z,E)-N-(2-Methylpropyl)-2,6,8-decatrienamide (CAS 25394-57-4) is a chemical substance. Key regulatory status: 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat.

View cosmetic safety profile for Spilanthol →

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 9 fields

Name

(E,Z,E)-N-(2-Methylpropyl)-2,6,8-decatrienamide

CAS Number

25394-57-4

DTXSID

DTXSID90893963

Molecular Formula

C14H23NO

InChI Key

BXOCHUWSGYYSFW-HVWOQQCMSA-N

Monoisotopic Mass

221.177964

Synonyms

2,6,8-Decatrienamide, N-isobutyl-, (E,Z,E)-SpilantholN-Isobutyl-2E-decenamide

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 1 records

Flavouring and nutrient

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 1 records

List	Keyword	Source
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)	FDA	United States Food and Drug Administration (FDA)

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 6 of 6 studies

Value	Unit	Endpoint	Route	Species	Source
4W9L3S4856	UNII	FDA UNII substance identifier	-	-	openFDA substances
4W9L3S4856	UNII	FDA UNII substance identifier	-	-	openFDA substances
4W9L3S4856	UNII	FDA UNII substance identifier	-	-	openFDA substances
4W9L3S4856	UNII	FDA UNII substance identifier	-	-	openFDA substances
=23.4	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_EFSA
=23.4	mg/kg bw/day	NOAEL	oral: feed	Rat	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx

Showing 6 of 6 studies

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

permitted

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL Spilanthol

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the NOAEL for (E,Z,E)-N-(2-Methylpropyl)-2,6,8-decatrienamide?

(E,Z,E)-N-(2-Methylpropyl)-2,6,8-decatrienamide has 6 NOAEL studies in the database. The lowest reported value is 4W9L3S4856 UNII. Source: openFDA substances.

What regulatory lists include (E,Z,E)-N-(2-Methylpropyl)-2,6,8-decatrienamide?

(E,Z,E)-N-(2-Methylpropyl)-2,6,8-decatrienamide appears on 1 regulatory/inventory list including food_additive; Substances Added to Food (formerly EAFUS) (2/2019). Source: EPA CPDat.

Is (E,Z,E)-N-(2-Methylpropyl)-2,6,8-decatrienamide used in cosmetics?

Yes, (E,Z,E)-N-(2-Methylpropyl)-2,6,8-decatrienamide is also indexed as a cosmetic ingredient under the name Spilanthol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for (E,Z,E)-N-(2-Methylpropyl)-2,6,8-decatrienamide come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Is (E,Z,E)-N-(2-Methylpropyl)-2,6,8-decatrienamide used outside industrial chemicals?

(E,Z,E)-N-(2-Methylpropyl)-2,6,8-decatrienamide also appears in cosmetics, pharmaceutical, cannabis databases.