Spilanthol

INCI: SPILANTHOL

CAS Number
25394-57-4
Function
Skin conditioning, anti-wrinkle (muscle relaxant / bio-Botox)
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Not restricted; GRAS as food flavoring agent (FEMA 4668); JECFA evaluated with no safety concern at current intake levels

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
high
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Bioactive compound with limited pregnancy and breastfeeding data; can potentiate absorption of other actives and should not be layered with AHAs or retinoids; limited long-term dermal safety data available.

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Concern Level: Low

Regulatory Flags

fda_food_additive

Frequently Asked Questions

Is Spilanthol safe in cosmetics?

Bioactive compound with limited pregnancy and breastfeeding data; can potentiate absorption of other actives and should not be layered with AHAs or retinoids; limited long-term dermal safety data available. The EU classifies Spilanthol as "permitted". Safety rating: GOOD.

Is Spilanthol allowed in the EU?

Spilanthol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Spilanthol do in cosmetics?

Spilanthol functions as: Skin conditioning, anti-wrinkle (muscle relaxant / bio-Botox). It is classified as a cosmetic ingredient in our database. CAS number: 25394-57-4.

What is the Margin of Safety for Spilanthol?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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