Is Spilanthol safe in cosmetics?
Spilanthol has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Spilanthol
Also known as: 2,6,8-Decatrienamide, N-isobutyl-, (E,Z,E)-, N-Isobutyl-2E-decenamide
INCI: SPILANTHOL
Spilanthol (CAS 25394-57-4) is a cosmetic cosmetic ingredient functioning as Skin conditioning, anti-wrinkle (muscle relaxant / bio-Botox). EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 25394-57-4 →
Auto-generated CPSR Part A draft with source citations
Function
Skin conditioning, anti-wrinkle (muscle relaxant / bio-Botox)
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
(2E,6Z,8E)-N-(2-methylpropyl)deca-2,6,8-trienamide
InChIKey
BXOCHUWSGYYSFW-HVWOQQCMSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Not restricted; GRAS as food flavoring agent (FEMA 4668); JECFA evaluated with no safety concern at current intake levels
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Spilanthol.
Calculate MoS for your specific formulation with the MoS Calculator.
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (1)
JECFA Evaluation
(2E,6E/Z,8E)-N-(2-METHYLPROPYL)-2,6,8-DECATRIENAMIDE | 2012 | No safety concern at current levels of intake when used as a flavouring agent | TRS 974-JECFA 76 | FAS 67 JECFA 76
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Regulatory List Membership (1)
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Spilanthol.
Regulatory Flags
fda_food_additive
Known Synonyms
2,6,8-Decatrienamide, N-isobutyl-, (E,Z,E)-
N-Isobutyl-2E-decenamide
Chemical Function
Flavouring and nutrient
Regulatory Lists
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Frequently Asked Questions
Is Spilanthol allowed in the EU?
Spilanthol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Spilanthol do in cosmetics?
Spilanthol functions as: Skin conditioning, anti-wrinkle (muscle relaxant / bio-Botox). It is classified as a cosmetic ingredient in our database. CAS number: 25394-57-4.
Compliance Tools
Check Spilanthol compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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