What is the NOAEL for 2H-1,4-Benzoxazin-6-ol, 3,4-dihydro-?
2H-1,4-Benzoxazin-6-ol, 3,4-dihydro- has 7 NOAEL studies in the database. The lowest reported value is 0.12 mg/m3 via inhalation in Human. Source: ToxValDB GESTIS DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
2H-1,4-Benzoxazin-6-ol, 3,4-dihydro-
Also known as: EINECS 247-415-5, UNII-77OXT3492A
CAS 26021-57-8
2H-1,4-Benzoxazin-6-ol, 3,4-dihydro- (CAS 26021-57-8) is a chemical substance. Key regulatory status: REACH registered, 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH.
Cross-Vertical Regulatory Divergence
2H-1,4-Benzoxazin-6-ol, 3,4-dihydro- is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H319, H411).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
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NOAEL studies
NOAEL studies
7
SOURCE
Chemical inventory jurisdictions
Regulatory lists
2
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EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
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DSSTox identifiers
8 fields
Name
2H-1,4-Benzoxazin-6-ol, 3,4-dihydro-
CAS Number
26021-57-8
DTXSID
DTXSID20180671
Molecular Formula
C8H9NO2
InChI Key
HWWIVWKTKZAORO-UHFFFAOYSA-N
Monoisotopic Mass
151.063329
Synonyms
EINECS 247-415-5UNII-77OXT3492A
Functional Uses
Industrial and product-use categories associated with this substance.
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EPA CPDat
4 records
Dye
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
2 records
| List | Keyword | Source |
|---|---|---|
| Europe; Personal care; restricted | European Commission | CosIng |
| Europe; Personal care - hair coloring | Danish Environmental Protection Agency | Danish EPA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
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NOAEL studies
Showing 7 of 7 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =0.12 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB GESTIS DNEL |
| 77OXT3492A | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 77OXT3492A | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 77OXT3492A | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 77OXT3492A | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 100 | mg/kg bw/day | LOAEL | oral | rat | COSMOS DB |
| 10 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
Showing 7 of 7 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
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ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 3,4-dihydro-2H-1,4-benzoxazin-6-ol | 247-415-5 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
SCCS Opinions
EU Scientific Committee opinions tied to the matched substance.
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SCCS Opinion
1 opinions
| Opinion | Date | Conclusion | Max Conc. | Concerns |
|---|---|---|---|---|
| SCCP/0948/05 | 20 June 2006 | safe | 1.0% | sensitisation not excluded |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Colorant
Frequently Asked Questions
What regulatory lists include 2H-1,4-Benzoxazin-6-ol, 3,4-dihydro-?
2H-1,4-Benzoxazin-6-ol, 3,4-dihydro- appears on 2 regulatory/inventory lists including Europe; Personal care; restricted, Europe; Personal care - hair coloring. Source: EPA CPDat.
Is 2H-1,4-Benzoxazin-6-ol, 3,4-dihydro- used in cosmetics?
Yes, 2H-1,4-Benzoxazin-6-ol, 3,4-dihydro- is also indexed as a cosmetic ingredient under the name Hydroxybenzomorpholine. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 2H-1,4-Benzoxazin-6-ol, 3,4-dihydro- come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.
Does 2H-1,4-Benzoxazin-6-ol, 3,4-dihydro- have different safety status in cosmetics vs industrial chemicals?
2H-1,4-Benzoxazin-6-ol, 3,4-dihydro- is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H319, H411).
Is 2H-1,4-Benzoxazin-6-ol, 3,4-dihydro- used outside industrial chemicals?
2H-1,4-Benzoxazin-6-ol, 3,4-dihydro- also appears in cosmetics databases.