Hydroxybenzomorpholine
INCI: HYDROXYBENZOMORPHOLINE
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
4 study endpoints found for Hydroxybenzomorpholine. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 10 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| LOAEL | 100 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 10 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | >=125 mg/kg bw/day | oral | rat | oral | REACH |
Sensitization Profile
Contact sensitization data for Hydroxybenzomorpholine based on clinical patch test studies and IFRA standards.
Source: IVDK; NACDG; ESSCA
Expert Verdict
Nitrosamine formation risk when used with nitrosating agents; practically nonirritating to eyes with slight skin irritation potential; not mutagenic in bacterial or micronucleus assays
Regulatory Flags
Frequently Asked Questions
Is Hydroxybenzomorpholine safe in cosmetics?
Nitrosamine formation risk when used with nitrosating agents; practically nonirritating to eyes with slight skin irritation potential; not mutagenic in bacterial or micronucleus assays The EU classifies Hydroxybenzomorpholine as "prohibited". Safety rating: GOOD. 4 toxicological study endpoint(s) are available in our database.
Is Hydroxybenzomorpholine allowed in the EU?
Hydroxybenzomorpholine EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Hydroxybenzomorpholine do in cosmetics?
Hydroxybenzomorpholine functions as: Hair dye (oxidative/permanent). It is classified as a cosmetic ingredient in our database. CAS number: 26021-57-8.
What is the Margin of Safety for Hydroxybenzomorpholine?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Hydroxybenzomorpholine?
The NOAEL (No Observed Adverse Effect Level) for Hydroxybenzomorpholine is 10 mg/kg bw/day based on a Short Term Toxicity study via oral route in rat. A total of 4 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
Check Hydroxybenzomorpholine compliance across multiple jurisdictions:
Related Ingredients
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