Is Hydroxybenzomorpholine safe in cosmetics?
Hydroxybenzomorpholine has a safety rating of "GOOD" in our database. EU status: prohibited. US status: permitted.
Hydroxybenzomorpholine
Also known as: EINECS 247-415-5, UNII-77OXT3492A
INCI: HYDROXYBENZOMORPHOLINE
Hydroxybenzomorpholine (CAS 26021-57-8) is a cosmetic cosmetic ingredient functioning as Hair dye (oxidative/permanent). NOAEL 10 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 26021-57-8 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Hydroxybenzomorpholine is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H319, H411).
Source: Cosmetics: ingredients.eu status; Chemicals: ghs classifications.signal word/hazard statement code
Function
Hair dye (oxidative/permanent)
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
3,4-dihydro-2H-1,4-benzoxazin-6-ol
InChIKey
HWWIVWKTKZAORO-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
Permitted under coal-tar hair dye exemption; CIR Expert Panel concluded safe as a hair dye ingredient
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Hydroxybenzomorpholine.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Hydroxybenzomorpholine across SCCS product categories, with measured dermal absorption where available.
Sensitization Profile
Contact sensitization data for Hydroxybenzomorpholine based on clinical patch test studies and IFRA standards.
Sensitization Rate
low
Allergen Class
dye
EU Allergen Listed
no
Patch Test Positive Rate
0.2%
Cross-reactivity Group
para-amino-group
Reaction Type
contact-dermatitis
Source: IVDK; NACDG; ESSCA
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (III - Restricted)
Product type: Hair dye substance in oxidative hair dye products.
BRIN Brazil/India Cosmetics
India: Restricted
Additional Jurisdictional Restrictions (2)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| CN | permitted_hair_dye | 1 | Oxidative hair dye products |
| IN | restricted | 1.0 | oxidative hair dye only |
Additional Ingredient Properties
2 property records from structured ingredient metadata.
allergen_detail
{"eu_allergen_listed": "no", "allergen_class": "dye", "cross_reactivity_group": "para-amino-group", "patch_test_frequency_pct": "0.2", "sensitization_rate": "low", "common_reaction_type": "contact-dermatitis", "ifra_restricted": "no", "source": "IVDK; NACDG; ESSCA"}
hair_dye
{"cas_number": "26021-57-8", "ingredient_class": "oxidative_dye_coupler", "chemical_class": "other", "molecular_weight_Da": "151.16", "color_result_on_hair": "Ash modifier", "shade_range": "brown", "primary_function": "coupler", "oxidative_dye_type": "coupler", "requires_developer": "yes", "permanence": "permanent", "oxidation_mechanism": "coupling", "coupling_position": "meta", "hair_penetration_…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Regulatory List Membership (1)
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for Hydroxybenzomorpholine.
Regulatory Flags
eu_cosing_listed
Known Synonyms
EINECS 247-415-5
UNII-77OXT3492A
Chemical Function
Dye
Regulatory Lists
Europe; Personal care; restricted
Europe; Personal care - hair coloring
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Hydroxybenzomorpholine allowed in the EU?
Hydroxybenzomorpholine EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Hydroxybenzomorpholine do in cosmetics?
Hydroxybenzomorpholine functions as: Hair dye (oxidative/permanent). It is classified as a cosmetic ingredient in our database. CAS number: 26021-57-8.
Is Hydroxybenzomorpholine used outside cosmetics?
Hydroxybenzomorpholine also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Hydroxybenzomorpholine have different safety status in cosmetics vs industrial chemicals?
Hydroxybenzomorpholine is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H319, H411).
Compliance Tools
Check Hydroxybenzomorpholine compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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