CAS 27080-42-8
4-Nitrophenyl aminoethylurea (CAS 27080-42-8) is a chemical substance with GHS signal word Warning; key hazard signal: H317; H412. Key regulatory status: REACH registered, 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH.
View cosmetic safety profile for 4-Nitrophenyl Aminoethylurea →
CAS, identifiers, formula, and alternate names for the matched substance record.
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Skin Sens. 1; Aquatic Chronic 3 | H317; H412 | GHS07 | Warning |
Industrial and product-use categories associated with this substance.
Inventory, screening, and regulatory list matches from public chemical databases.
| List | Keyword | Source |
|---|---|---|
| Europe; Personal care; restricted | European Commission | CosIng |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 5 | mg/kg bw/d | - | - | - | Regulatory source |
| 50 | mg/kg bw | - | - | - | Regulatory source |
| 125 | mg/kg bw | - | - | - | Regulatory source |
| 1G48T8PRLV | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1 | mg/kg bw/day | LOAEL | oral | rat | COSMOS DB |
| =0.01 | mg/kg bw/d | NOAEL | oral | rat | SCCS Opinion |
| =5 | mg/kg bw | NOAEL | - | rat | SCCS Opinion |
| =5 | mg/kg bw/d | NOAEL | - | - | SCCS Opinion |
| =50 | mg/kg bw | NOAEL | - | - | SCCS Opinion |
| =125 | mg/kg bw | NOAEL | - | rat | SCCS Opinion |
| =0.01 | mg/kg bw/d | dermal absorption | oral | rat | Regulatory source |
| =5 | mg/kg bw/d | dermal absorption | oral | rat | Regulatory source |
| 50 | mg/kg bw | developmental toxicity | dermal | rat | Regulatory source |
| 50 | mg/kg bw | developmental toxicity | - | rat | Regulatory source |
| 5 | mg/kg bw | genotoxicity | - | rat | Regulatory source |
| 125 | mg/kg bw | genotoxicity | - | rat | Regulatory source |
| 5 | mg/kg bw | repeated dose toxicity | oral | rat | Regulatory source |
| 5 | mg/kg bw/day | repeated dose toxicity | oral | rat | Regulatory source |
| 125 | mg/kg bw | repeated dose toxicity | oral | rat | Regulatory source |
Showing 19 of 19 studies
Registration status from the ECHA REACH registered substances database.
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | [2-[(4-nitrophenyl)amino]ethyl]urea | 410-700-1 | ECHA overview → |
Australian industrial chemicals inventory status and applicable conditions.
EU Scientific Committee opinions tied to the matched substance.
| Opinion | Date | Conclusion | Max Conc. | Concerns |
|---|---|---|---|---|
| SCCP/1037/06 | 2007-06-19 | The SCCP is of the opinion that the information submitted is insufficient to allow a final risk assessment to be carried out. An additional mutagenicity / genotoxicity test should be performed following the relevant SCCNFP/SCCP opinions and in accordance with its Notes of Guidance in order to exclude its gene mutation potential. | - | Additional mutagenicity/genotoxicity test required to exclude gene mutation potential; secondary amine - should not be used with nitrosating substances, nitrosamine content < 50 ppb; stability in presence of hydrogen peroxide should be demonstrated. |
| SCCS/1369/10 | 21 September 2010 | Based on the data provided, the SCCS is of the opinion that the use of 4-nitrophenyl aminoethylurea with a maximum on-head concentration of 0.25% in oxidative and 0.5% in non-oxidative hair dye formulations does not pose a risk to the health of the consumer. | 0.25% oxidative; 0.5% non-oxidative (on-head) | It is a secondary amine; should not be used in combination with nitrosating substances; nitrosamine content should be < 50 ppb. |
Same-CAS cosmetic ingredient record for cross-vertical context.
4-Nitrophenyl aminoethylurea (CAS 27080-42-8) is classified under EU CLP Annex VI as Skin Sens. 1; Aquatic Chronic 3 with signal word Warning. Hazard statements: H317; H412. Source: EU CLP Annex VI (ECHA).
4-Nitrophenyl aminoethylurea has 19 NOAEL studies in the database. The lowest reported value is 0.01 mg/kg bw/d via oral in rat. Source: SCCS Opinion.
4-Nitrophenyl aminoethylurea appears on 1 regulatory/inventory list including Europe; Personal care; restricted. Source: EPA CPDat.
Yes, 4-Nitrophenyl aminoethylurea is also indexed as a cosmetic ingredient under the name 4-Nitrophenyl Aminoethylurea. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.
4-Nitrophenyl aminoethylurea also appears in cosmetics databases.