Is 4-Nitrophenyl Aminoethylurea safe in cosmetics?
4-Nitrophenyl Aminoethylurea has a safety rating of "MODERATE" in our database. EU status: restricted. US status: permitted. 10 toxicological study endpoint(s) are available in our database.
4-Nitrophenyl Aminoethylurea
INCI: 4-NITROPHENYL AMINOETHYLUREA
4-Nitrophenyl Aminoethylurea (CAS 27080-42-8) is a cosmetic cosmetic ingredient functioning as Hair dye (direct / semi-permanent, yellow shade). Reported NOAEL =0.01 mg/kg bw/d in rat (SCCS Opinion); EU Regulation 1223/2009 status: restricted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 27080-42-8 →
Function
Hair dye (direct / semi-permanent, yellow shade)
Editorial assessment
MODERATE
Preliminary editorial note — not a computed safety verdict.
Regulatory Status
EU EU Status
restricted
US US Status
permitted
US Notes
Permitted for use in hair dyes; FDA does not pre-approve hair dye ingredients except coal-tar colors requiring certification
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for 4-Nitrophenyl Aminoethylurea.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for 4-Nitrophenyl Aminoethylurea. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =0.01 mg/kg bw/d | oral | rat | dermal absorption | SCCS Opinion |
| NOAEL | =0.01 mg/kg bw/d | oral | rat | dermal absorption | SCCS Opinion |
| NOAEL | =0.01 mg/kg bw/d | oral | rat | dermal absorption | SCCS Opinion |
| NOAEL | =0.01 mg/kg bw/d | oral | rat | dermal absorption | SCCS Opinion |
| NOAEL | =5 mg/kg bw | - | rat | genotoxicity | SCCS Opinion |
| NOAEL | =5 mg/kg bw/d | - | - | NOAEL study | SCCS Opinion |
| NOAEL | =5 mg/kg bw | - | rat | genotoxicity | SCCS Opinion |
| NOAEL | =5 mg/kg bw | - | rat | genotoxicity | SCCS Opinion |
| NOAEL | =5 mg/kg bw/d | - | - | NOAEL study | SCCS Opinion |
| NOAEL | =5 mg/kg bw/d | - | - | NOAEL study | SCCS Opinion |
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Warning
Pictograms
Harmful / Irritant
Hazard Class and Category
Skin Sens. 1; Aquatic Chronic 3
Hazard Statements
- H317 May cause an allergic skin reaction
- H412 Harmful to aquatic life with long lasting effects
Inserted via ATP: CLP00
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
No longer valid
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (III - Restricted)
Product type: (a) Hair dye substance in oxidative hair dye products (b) Hair dye substance in non-oxidative hair dye products. Max: (b) 0.5%.
BRIN Brazil/India Cosmetics
India: Restricted · max (b) 0.5%
Additional Jurisdictional Restrictions (1)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| KR | prohibited | - | - |
Expanded Dermal Absorption Data
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
Aggregated DA Values (5 records across 5 sources)
| Type | DA % | Method | Skin Model | SCCS Ref |
|---|---|---|---|---|
| measured | 0.103% | - | - | SCCP/0103 |
| measured | 0.5% | in_vitro | - | SCCP/0103 |
| measured | 0.0132% | - | - | SCCP/0103 |
| measured | 0.25% | in_vitro | - | SCCP/0103 |
| measured | 1.44% | - | - | SCCP/0103 |
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Regulatory List Membership (1)
EU CosIng Cosmetics Ingredient Database
Editorial summary
Preliminary editorial summary for 4-Nitrophenyl Aminoethylurea — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
eu_cosing_listed
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to 4-Nitrophenyl Aminoethylurea by CAS number or substance name.
Studies
20
Lowest NOAEL
0.01
Highest NOAEL
125
Units vary across source rows: mg/kg bw/d, mg/kg bw
SCCS Opinion
Dermal Absorption
View details ->| Absorption % | Method | Vehicle |
|---|---|---|
| 0.103% | - | - |
| 0.5% | in_vitro | - |
| 0.0132% | - | - |
| 0.25% | in_vitro | - |
| 1.44% | - | - |
Chemical Function
Dye
Regulatory Lists
Europe; Personal care; restricted
Australian Status
AICIS status: listed
Frequently Asked Questions
Is 4-Nitrophenyl Aminoethylurea allowed in the EU?
4-Nitrophenyl Aminoethylurea EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does 4-Nitrophenyl Aminoethylurea do in cosmetics?
4-Nitrophenyl Aminoethylurea functions as: Hair dye (direct / semi-permanent, yellow shade). It is classified as a cosmetic ingredient in our database. CAS number: 27080-42-8.
What is the NOAEL for 4-Nitrophenyl Aminoethylurea?
The NOAEL (No Observed Adverse Effect Level) for 4-Nitrophenyl Aminoethylurea is =0.01 mg/kg bw/d based on a dermal absorption study via oral route in rat. A total of 10 study endpoints are available. Source: SCCS Opinion.
Is 4-Nitrophenyl Aminoethylurea used outside cosmetics?
4-Nitrophenyl Aminoethylurea also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check 4-Nitrophenyl Aminoethylurea compliance across multiple jurisdictions:
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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