NOAEL Data IARC Group 3 REACH Registered Cosmetic Ingredient

FD&C Yellow 6

Also known as: C.I. 15985, C.I. Food Yellow 3, 2-Naphthalenesulfonic acid, 6-hydroxy-5-[(4-sulfophenyl)azo]-, disodium salt, D and C Yellow 6, L. Orange Z2010 (+15 more)

CAS 2783-94-0

FD&C Yellow 6 (CAS 2783-94-0) is a chemical substance; key hazard signal: IARC Group 3. Key regulatory status: REACH registered, 12 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, IARC, ECHA REACH.

View cosmetic safety profile for CI 15985 Yellow 6 Lake →

SOURCE NOAEL studies
NOAEL studies
63
SOURCE Chemical inventory jurisdictions
Regulatory lists
12
SOURCE EU CLP Annex VI
GHS signal
Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 25 fields
Name
FD&C Yellow 6
CAS Number
2783-94-0
Molecular Formula
C16H12N2O7S2.2Na
InChI Key
OIQPTROHQCGFEF-UHFFFAOYSA-L
Monoisotopic Mass
453.988132
Synonyms
C.I. 15985C.I. Food Yellow 32-Naphthalenesulfonic acid, 6-hydroxy-5-[(4-sulfophenyl)azo]-, disodium saltD and C Yellow 6L. Orange Z2010A.F. Yellow No. 5Aizen Food Yellow No. 5Disodium 6-hydroxy-5-((4-sulfophenyl)azo)-2-naphthalenesulfonateDisodium salt of 1-p-sulphophenylazo-2-naphthol-6-sulphonic acidDye FDC Yellow No. 6Dye Sunset YellowEINECS 220-491-7

IARC Carcinogen Classification

Carcinogenic hazard classification from IARC monograph evaluations.

SOURCE IARC Monographs on the Identification of Carcinogenic Hazards to Humans 1 records
GroupMeaningEvaluatedVolume
Group 3Not classifiable19878, Sup 7

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 60 records
DyeFragrance

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 12 records
ListKeywordSource
IFRA TransparencyIFRAIFRA
inert_ingredient; non_food_use; PesticidesEPACPCat
children; Europe; Personal careDanish Environmental Protection AgencyDanish EPA
children; Europe; Personal care - specialized bath products - bath saltsDanish Environmental Protection AgencyDanish EPA
children; Europe; Personal care - hair styling and care - shampooDanish Environmental Protection AgencyDanish EPA
children; Europe; Personal careDanish Environmental Protection AgencyDanish EPA
children; Europe; Personal careDanish Environmental Protection AgencyDanish EPA
general_foodsFDAUnited States Food and Drug Administration (FDA)
pharmaceuticalFDAUnited States Food and Drug Administration (FDA)
Personal careFDAUnited States Food and Drug Administration (FDA)
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)FDAUnited States Food and Drug Administration (FDA)
SCIL (9/2019)USEPASafer Chemical Ingredients List

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 63 studies
ValueUnitEndpointRouteSpeciesSource
range:0-0.1250.125mg/kg bw/dayADIoralMouseWHO/JECFA
range:0-0.50.5mg/kg bw/dayADI--WHO/JECFA
range:0-0.60.6mg/kg bw/dayADI--WHO/JECFA
range:0-0.750.75mg/kg bw/dayADIoralRatWHO/JECFA
range:0-0.80.8mg/kg bw/dayADI--WHO/JECFA
range:0-11mg/kg bw/dayADIoralRatWHO/JECFA
=1mg/kg bw/dayADI-ConsumersEFSA
range:0-2.52.5mg/kg bw/dayADI--WHO/JECFA
range:0-44mg/kg bw/dayADI-Rat; MouseWHO/JECFA
=4mg/kg bw/dayADI-ConsumersEFSA
range:0-55mg/kg bw/dayADI--WHO/JECFA
range:0-1010mg/kg bw/dayADI--WHO/JECFA
=50mg/kg bw/dayADIoral-WHO/JECFA
=1mg/kg bw/dayADI (provisional)-ConsumersEFSA
18.9uL/min/10^6 cellsClint-HumanNTP ICE adme parameters
=1469mg/m3DNEL systemicinhalationHumanToxValDB GESTIS DNEL
H77VEI93A8UNIIFDA UNII substance identifier--openFDA substances
1.380e-7fractionFu-HumanNTP ICE adme parameters
3IARC groupIARC carcinogenicity classification--IARC Monographs
3unitlessIARC group--NTP ICE cancer
>2000mg/kg bwLD50oralRatNTP ICE acute oral
>1.000e+4mg/kg bwLD50oralRatNTP ICE acute oral
=625mg/kg bw/dayLELoralRatToxValDB ToxRefDB
=625mg/kg bw/dayLELoralrat (fischer; Fischer 344)EPA ToxRefDB v3
=900mg/kg bw/dayLELoralMouseToxValDB ToxRefDB
=900mg/kg bw/dayLELoralmouse (b6c3f1; B6C3F1)EPA ToxRefDB v3
>1250mg/kg bw/dayLELoralrat (fischer; Fischer 344)EPA ToxRefDB v3
=3750mg/kg bw/dayLELoralMouseToxValDB ToxRefDB
=3750mg/kg bw/dayLELoralmouse (b6c3f1; B6C3F1)EPA ToxRefDB v3
=1.35mg/kg bw/dayLOAELoralRatWHO/JECFA
=2.4mg/kg bw/dayLOAEL--WHO/JECFA
=20mg/kg bw/dayLOAEL-HamsterWHO/JECFA
~31mg/kg bw/dayLOAEL--WHO/JECFA
~35mg/kg bw/dayLOAEL--WHO/JECFA
range:50-7575mg/kg bw/dayLOAEL--WHO/JECFA
=100mg/kg bw/dayLOAEL--WHO/JECFA
=300mg/kg bw/dayLOAELoralRatToxValDB HPVIS
=600mg/kg bw/dayLOAELoralMouseECHA
=1170mg/kg bw/dayLOAELoralRatECHA
=1200mg/kg bw/dayLOAELoralRatECHA
=1950mg/kg bw/dayLOAELoralRatToxValDB HPVIS
=2400mg/kg bw/dayLOAELoralRatECHA
=2500mg/kg bw/dayLOAELoralRatToxValDB ToxRefDB
=2500mg/kg bw/dayLOAELoralrat (fischer; Fischer 344)EPA ToxRefDB v3
=4625mg/kg bw/dayLOAELoralMouseToxValDB HPVIS
=1.500e+4mg/kg bw/dayLOAELoralMouseToxValDB ToxRefDB
=1.500e+4mg/kg bw/dayLOAELoralmouse (b6c3f1; B6C3F1)EPA ToxRefDB v3
=1.970e+4mg/kg bw/dayLOAELoralMouseECHA
=1000mg/kg bw/dayLOELoralRatECHA
0unitlessModel Score--NTP ICE endocrine

Showing 50 of 63 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA 1 records
StatusNameEC NumberLink
RegisteredDisodium 6-hydroxy-5-[(4-sulphonatophenyl)azo]naphthalene-2-sulphonate220-491-7ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
permitted
Max
3%
Category
colorant
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE ChEMBL / DailyMed E110
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
View full pharmaceutical profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA 1 records

E110 — ADI: 4 mg/kg bw

View full food safety profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the NOAEL for FD&C Yellow 6?

FD&C Yellow 6 has 63 NOAEL studies in the database. The lowest reported value is 0 unitless. Source: NTP ICE endocrine.

What regulatory lists include FD&C Yellow 6?

FD&C Yellow 6 appears on 10 regulatory/inventory lists including IFRA Transparency, inert_ingredient; non_food_use; Pesticides, children; Europe; Personal care, and 7 more. Source: EPA CPDat.

Is FD&C Yellow 6 a carcinogen according to IARC?

FD&C Yellow 6 is classified by IARC as Group 3 — not classifiable as to its carcinogenicity to humans (evaluated 1987). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.

Is FD&C Yellow 6 used in cosmetics?

Yes, FD&C Yellow 6 is also indexed as a cosmetic ingredient under the name CI 15985 Yellow 6 Lake. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for FD&C Yellow 6 come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, IARC Monographs, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Is FD&C Yellow 6 used outside industrial chemicals?

FD&C Yellow 6 also appears in cosmetics, pharmaceutical, food safety, cannabis databases.