Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for CI 15985 Yellow 6 Lake. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 1000 mg/kg bw/day | oral | swine | Subchronic | COSMOS_DB |
| NOAEL | 2400 mg/kg bw/day | oral | mouse | Chronic | COSMOS_DB |
| NOAEL | 500 mg/kg bw/day | oral | rat | Multigeneration Reproductive | COSMOS_DB |
| NOAEL | 1000 mg/kg bw/day | oral | rabbit | Developmental | COSMOS_DB |
| NOAEL | 1000 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
| NOAEL | 1000 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| NOAEL | 750 mg/kg bw/day | oral | rat | Carcinogenicity | COSMOS_DB |
| NOAEL | 2500 mg/kg bw/day | oral | rat | Carcinogenicity | COSMOS_DB |
| NOAEL | 7500 mg/kg bw/day | oral | mouse | Carcinogenicity | COSMOS_DB |
| NOAEL | 300 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
Expert Verdict
CI 15985 Yellow 6 Lake is a permitted colorant with regulatory approval in EU and OTC drug status in US; however, insufficient safety data exists and further assessment is recommended.
Regulatory Flags
Frequently Asked Questions
Is CI 15985 Yellow 6 Lake safe in cosmetics?
CI 15985 Yellow 6 Lake is a permitted colorant with regulatory approval in EU and OTC drug status in US; however, insufficient safety data exists and further assessment is recommended. The EU classifies CI 15985 Yellow 6 Lake as "permitted". Safety rating: MODERATE. 10 toxicological study endpoint(s) are available in our database.
Is CI 15985 Yellow 6 Lake allowed in the EU?
CI 15985 Yellow 6 Lake EU regulatory status: permitted. Maximum allowed concentration: 3%. This is based on EU Regulation 1223/2009 and its amendments.
What does CI 15985 Yellow 6 Lake do in cosmetics?
CI 15985 Yellow 6 Lake functions as: cosmetic colorant. It is classified as a Colorant in our database. CAS number: 2783-94-0.
What is the Margin of Safety for CI 15985 Yellow 6 Lake?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for CI 15985 Yellow 6 Lake?
The NOAEL (No Observed Adverse Effect Level) for CI 15985 Yellow 6 Lake is 1000 mg/kg bw/day based on a Subchronic study via oral route in swine. A total of 10 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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