NOAEL Data Cosmetic Ingredient

1,4-Benzenediamine, 2-nitro-N1-phenyl-

Also known as: EINECS 220-494-3, HC Red No. 1, 2-Nitro-4-aminodiphenylamine, 2-Nitro-N1-phenyl-1,4-benzenediamine, 2-Nitro-N(sup 1)-phenyl-1,4-benzenediamine (+2 more)

CAS 2784-89-6

1,4-Benzenediamine, 2-nitro-N1-phenyl- (CAS 2784-89-6) is a chemical substance. Key regulatory status: 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, SCCS.

View cosmetic safety profile for HC RED NO. 1 →

Cross-Vertical Regulatory Divergence

1,4-Benzenediamine, 2-nitro-N1-phenyl- is prohibited in EU cosmetics at max Annex III/258 but has active industrial GHS classifications (H302, H317, H319).

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code

SOURCE NOAEL studies

NOAEL studies

SOURCE Chemical inventory jurisdictions

Regulatory lists

SOURCE EU CLP Annex VI

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 12 fields

Name

1,4-Benzenediamine, 2-nitro-N1-phenyl-

CAS Number

2784-89-6

Molecular Formula

C12H11N3O2

InChI Key

WHJNKCNHEVCICH-UHFFFAOYSA-N

Monoisotopic Mass

229.085127

Synonyms

EINECS 220-494-3HC Red No. 12-Nitro-4-aminodiphenylamine2-Nitro-N1-phenyl-1,4-benzenediamine2-Nitro-N(sup 1)-phenyl-1,4-benzenediaminep-Phenylenediamine, 2-nitro-N(sup 1)-phenyl-UNII-1FZM1701IS

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 4 records

Dye

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 1 records

List	Keyword	Source
Europe; Personal care; restricted	European Commission	CosIng

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 19 of 19 studies

Value	Unit	Endpoint	Route	Species	Source
5	mg/kg bw/d	-	oral	rabbit	Regulatory source
20	mg/kg bw/d	-	oral	rabbit	Regulatory source
1FZM1701IS	UNII	FDA UNII substance identifier	-	-	openFDA substances
2	mg/kg bw/day	LOAEL	oral	rat	COSMOS DB
=0.0294	mg/kg	NOAEL	oral	rat	SCCS Opinion
=5	mg/kg bw/d	NOAEL	oral	rabbit	SCCS Opinion
=5	mg/kg	NOAEL	oral	rat	SCCS Opinion
=20	mg/kg bw/d	NOAEL	oral	rabbit	SCCS Opinion
=25	mg/kg/day	NOAEL	oral	-	SCCS Opinion
=50	mg/kg bw/d	NOAEL	oral	rat	SCCS Opinion
=125	mg/kg bw/d	NOAEL	-	-	SCCS Opinion
25	mg/kg/day	developmental toxicity	oral	-	Regulatory source
125	mg/kg bw/d	developmental toxicity	-	-	Regulatory source
=0.0294	mg/kg	repeated dose toxicity	oral	rat	Regulatory source
=5	mg/kg	repeated dose toxicity	oral	rat	Regulatory source
5	mg/kg bw/d	repeated dose toxicity	oral	rat	Regulatory source
25	mg/kg/day	repeated dose toxicity	oral	rat	Regulatory source
50	mg/kg bw/d	repeated dose toxicity	oral	rat	Regulatory source
125	mg/kg bw/d	repeated dose toxicity	dermal	mouse	Regulatory source

Showing 19 of 19 studies

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE SCCS Opinion 2 opinions

Opinion	Date	Conclusion	Max Conc.	Concerns
SCCP/0979/06	10 October 2006	safe	1.0%	secondary amine; nitrosamine <50ppb; sensitisation not excluded
SCCP/0981/06	10 October 2006	The SCCP is of the opinion that the use of HC Red n° 1 in semi-permanent hair dye formulation at a maximum final concentration of 1.0% does not pose a risk to the health of the consumer, apart from its sensitising property.	1.0%	Sensitising property; genotoxicity/mutagenicity studies of finished hair dye formulations should be undertaken per SCCNFP/SCCP opinions and Notes of Guidance.

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

prohibited

Max

Annex III/258

Frequently Asked Questions

What is the NOAEL for 1,4-Benzenediamine, 2-nitro-N1-phenyl-?

1,4-Benzenediamine, 2-nitro-N1-phenyl- has 19 NOAEL studies in the database. The lowest reported value is 5 mg/kg bw/d via oral in rabbit. Source: Regulatory source.

What regulatory lists include 1,4-Benzenediamine, 2-nitro-N1-phenyl-?

1,4-Benzenediamine, 2-nitro-N1-phenyl- appears on 1 regulatory/inventory list including Europe; Personal care; restricted. Source: EPA CPDat.

Is 1,4-Benzenediamine, 2-nitro-N1-phenyl- used in cosmetics?

Yes, 1,4-Benzenediamine, 2-nitro-N1-phenyl- is also indexed as a cosmetic ingredient under the name HC RED NO. 1. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 1,4-Benzenediamine, 2-nitro-N1-phenyl- come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.

Does 1,4-Benzenediamine, 2-nitro-N1-phenyl- have different safety status in cosmetics vs industrial chemicals?

1,4-Benzenediamine, 2-nitro-N1-phenyl- is prohibited in EU cosmetics at max Annex III/258 but has active industrial GHS classifications (H302, H317, H319).

Is 1,4-Benzenediamine, 2-nitro-N1-phenyl- used outside industrial chemicals?

1,4-Benzenediamine, 2-nitro-N1-phenyl- also appears in cosmetics databases.