Poor Cosmetic Ingredient NOAEL Data Sensitization Data

HC RED NO. 1

CAS Number
2784-89-6
Function
Hair Dyeing
Safety Rating
POOR

Regulatory Status

🇪🇺 EU Status Prohibited
EU Max Conc. Annex III/258
🇺🇸 US Status restricted
US Notes CIR: SQ - JACT 15(4):320-336, 1996; IJT 36(Suppl 2):14-58, 2017

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Toxicological Studies

1 study endpoint found for HC RED NO. 1. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
LOAEL 2 mg/kg bw/day oral rat Subchronic COSMOS_DB

Sensitization Profile

Contact sensitization data for HC RED NO. 1 based on clinical patch test studies and IFRA standards.

Sensitization Rate
low
Allergen Class
dye
EU Allergen Listed
no
Patch Test Positive Rate
0.2%
Cross-reactivity Group
para-amino-group
Reaction Type
contact-dermatitis

Source: SCCS; IVDK

Expert Verdict

HC RED NO. 1 is listed in the EU CosIng database with functions: Hair Dyeing It is prohibited under EU Cosmetics Regulation (Annex II).

⚠️
Concern Level: High

Regulatory Flags

cosing-sourced eu-prohibited needs-enrichment eu_cosing_listed

Frequently Asked Questions

Is HC RED NO. 1 safe in cosmetics?

HC RED NO. 1 is listed in the EU CosIng database with functions: Hair Dyeing It is prohibited under EU Cosmetics Regulation (Annex II). The EU classifies HC RED NO. 1 as "Prohibited". Safety rating: POOR. 1 toxicological study endpoint(s) are available in our database.

Is HC RED NO. 1 allowed in the EU?

HC RED NO. 1 EU regulatory status: Prohibited. Maximum allowed concentration: Annex III/258. This is based on EU Regulation 1223/2009 and its amendments.

What does HC RED NO. 1 do in cosmetics?

HC RED NO. 1 functions as: Hair Dyeing. It is classified as a cosmetic ingredient in our database. CAS number: 2784-89-6.

What is the NOAEL for HC RED NO. 1?

The NOAEL (No Observed Adverse Effect Level) for HC RED NO. 1 is 2 mg/kg bw/day based on a Subchronic study via oral route in rat. Source: COSMOS_DB.

Compliance Tools

Check HC RED NO. 1 compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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