Is HC RED NO. 1 safe in cosmetics?
HC RED NO. 1 has a safety rating of "POOR" in our database. EU status: prohibited. US status: restricted. 10 toxicological study endpoint(s) are available in our database.
HC RED NO. 1
Also known as: EINECS 220-494-3, 2-Nitro-4-aminodiphenylamine, 2-Nitro-N1-phenyl-1,4-benzenediamine, 2-Nitro-N(sup 1)-phenyl-1,4-benzenediamine, p-Phenylenediamine, 2-nitro-N(sup 1)-phenyl- (+1 more)
HC RED NO. 1 (CAS 2784-89-6) is a cosmetic cosmetic ingredient functioning as Hair Dyeing. Reported NOAEL =0.0294 mg/kg in rat (SCCS_vision_codex); EU Regulation 1223/2009 status: prohibited, max Annex III/258. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 2784-89-6 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
HC RED NO. 1 is prohibited in EU cosmetics at max Annex III/258 but has active industrial GHS classifications (H302, H317, H319).
Source: Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Hair Dyeing
Safety Rating
POOR
Chemistry & Identifiers
IUPAC Name
2-nitro-1-N-phenylbenzene-1,4-diamine
InChIKey
WHJNKCNHEVCICH-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
EU Max Conc.
Annex III/258
US US Status
restricted
US Notes
CIR: SQ - JACT 15(4):320-336, 1996; IJT 36(Suppl 2):14-58, 2017
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Toxicological Studies
10 study endpoints found for HC RED NO. 1. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =0.0294 mg/kg | oral | rat | repeated dose toxicity | SCCS_vision_codex |
| NOAEL | =0.0294 mg/kg | oral | rat | repeated dose toxicity | SCCS_vision_codex |
| NOAEL | =0.0294 mg/kg | oral | rat | repeated dose toxicity | SCCS_vision_codex |
| NOAEL | =0.0294 mg/kg | oral | rat | repeated dose toxicity | SCCS_vision_codex |
| NOAEL | =5 mg/kg bw/d | oral | rabbit | NOAEL study | SCCS_vision_codex |
| NOAEL | =5 mg/kg | oral | rat | repeated dose toxicity | SCCS_vision_codex |
| NOAEL | =5 mg/kg bw/d | oral | rabbit | NOAEL study | SCCS_vision_codex |
| NOAEL | =5 mg/kg | oral | rat | repeated dose toxicity | SCCS_vision_codex |
| NOAEL | =5 mg/kg bw/d | oral | rabbit | NOAEL study | SCCS_vision_codex |
| NOAEL | =5 mg/kg | oral | rat | repeated dose toxicity | SCCS_vision_codex |
Sensitization Profile
Contact sensitization data for HC RED NO. 1 based on clinical patch test studies and IFRA standards.
Sensitization Rate
low
Allergen Class
dye
EU Allergen Listed
no
Patch Test Positive Rate
0.2%
Cross-reactivity Group
para-amino-group
Reaction Type
contact-dermatitis
Source: SCCS; IVDK
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (III - Restricted)
Product type: Hair dye substance in non-oxidative hair dye products. Max: 1,0%.
BRIN Brazil/India Cosmetics
India: Restricted · max 1,0%
Additional Jurisdictional Restrictions (1)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| CN | permitted_hair_dye | 1 | Non-oxidative hair dye (direct) |
Additional Ingredient Properties
2 property records from structured ingredient metadata.
allergen_detail
{"eu_allergen_listed": "no", "allergen_class": "dye", "cross_reactivity_group": "para-amino-group", "patch_test_frequency_pct": "0.2", "sensitization_rate": "low", "common_reaction_type": "contact-dermatitis", "ifra_restricted": "no", "source": "SCCS; IVDK"}
hair_dye
{"cas_number": "2784-89-6", "ingredient_class": "direct_dye", "chemical_class": "nitro", "molecular_weight_Da": "168.15", "color_result_on_hair": "Red", "shade_range": "red", "primary_function": "direct_deposit", "requires_developer": "no", "lift_capability_levels": "0", "deposit_only": "yes", "permanence": "semi_permanent", "wash_fastness_shampoos": "6-12", "light_fastness": "moderate", "heat_sta…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Regulatory List Membership (1)
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for HC RED NO. 1.
Regulatory Flags
cosing-sourced
eu-prohibited
needs-enrichment
eu_cosing_listed
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to HC RED NO. 1 by CAS number or substance name.
Studies
28
Lowest NOAEL
0.0294
Highest NOAEL
125
Units vary across source rows: mg/kg bw/d, mg/kg/day, mg/kg
SCCS_vision_codex
Known Synonyms
EINECS 220-494-3
2-Nitro-4-aminodiphenylamine
2-Nitro-N1-phenyl-1,4-benzenediamine
2-Nitro-N(sup 1)-phenyl-1,4-benzenediamine
p-Phenylenediamine, 2-nitro-N(sup 1)-phenyl-
UNII-1FZM1701IS
Chemical Function
Dye
Regulatory Lists
Europe; Personal care; restricted
Australian Status
AICIS status: listed
Frequently Asked Questions
Is HC RED NO. 1 allowed in the EU?
HC RED NO. 1 EU regulatory status: prohibited. Maximum allowed concentration: Annex III/258. This is based on EU Regulation 1223/2009 and its amendments.
What does HC RED NO. 1 do in cosmetics?
HC RED NO. 1 functions as: Hair Dyeing. It is classified as a cosmetic ingredient in our database. CAS number: 2784-89-6.
What is the NOAEL for HC RED NO. 1?
The NOAEL (No Observed Adverse Effect Level) for HC RED NO. 1 is =0.0294 mg/kg based on a repeated dose toxicity study via oral route in rat. A total of 10 study endpoints are available. Source: SCCS_vision_codex.
Is HC RED NO. 1 used outside cosmetics?
HC RED NO. 1 also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does HC RED NO. 1 have different safety status in cosmetics vs industrial chemicals?
HC RED NO. 1 is prohibited in EU cosmetics at max Annex III/258 but has active industrial GHS classifications (H302, H317, H319).
Compliance Tools
Check HC RED NO. 1 compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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