What is the NOAEL for 2-Methoxy-4-propylphenol?
2-Methoxy-4-propylphenol has 19 NOAEL studies in the database. The lowest reported value is 0 % via Dermal. Source: NTP_ICE_skin_sensitization.
NOAEL Data
REACH Registered
Cosmetic Ingredient
2-Methoxy-4-propylphenol
Also known as: Dihydroeugenol, Phenol, 2-methoxy-4-propyl-, 4-06-00-05976, BRN 1866292, Cerulignol (+15 more)
CAS 2785-87-7
2-Methoxy-4-propylphenol (CAS 2785-87-7) is a chemical substance. Key regulatory status: REACH registered, 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
19
SOURCE
chemical inventory jurisdictions
Regulatory lists
4
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
2-Methoxy-4-propylphenol
CAS Number
2785-87-7
DTXSID
DTXSID2047199
Molecular Formula
C10H14O2
InChI Key
PXIKRTCSSLJURC-UHFFFAOYSA-N
Monoisotopic Mass
166.09938
Synonyms
DihydroeugenolPhenol, 2-methoxy-4-propyl-4-06-00-05976BRN 1866292CerulignolCoerulignolEINECS 220-499-0FEMA No. 3598Guaiacol, 4-propyl-Guaiacylpropane1-(4-Hydroxy-3-methoxyphenyl)propane(4-Hydroxy-3-methoxyphenyl)propane
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
24 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
4 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 19 of 19 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 24.6 | uL/min/10^6 cells | Clint | - | Human | NTP_ICE_adme_parameters |
| =6.07 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| - | % | Depletion Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 12.3 | % | Depletion Lys | Dermal | - | NTP_ICE_skin_sensitization |
| 462 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| 6.8 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| A3XE712277 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| A3XE712277 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| A3XE712277 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| A3XE712277 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.0707 | fraction | Fu | - | Human | NTP_ICE_adme_parameters |
| 759.2 | uM | IC50 | Dermal | - | NTP_ICE_skin_sensitization |
| 1.539 | ratio | Imax | Dermal | - | NTP_ICE_skin_sensitization |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 5400 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| =2600 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =67 | mg/kg bw/day | NOAEL | oral: unspecified | Rat | EFSA_OpenFoodTox_OpenFoodToxTX22809_2023.xlsx |
| =67 | mg/kg bw/day | NOAEL | oral: unspecified | Rat | EFSA_OpenFoodTox_OpenFoodToxTX22809_2023.xlsx |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 19 of 19 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 2-methoxy-4-propylphenol | 220-499-0 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL3186884
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
2
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include 2-Methoxy-4-propylphenol?
2-Methoxy-4-propylphenol appears on 4 regulatory/inventory lists including IFRA Transparency, Europe, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), and 1 more. Source: EPA CPDat.
Is 2-Methoxy-4-propylphenol used in cosmetics?
Yes, 2-Methoxy-4-propylphenol is also indexed as a cosmetic ingredient under the name Dihydroeugenol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 2-Methoxy-4-propylphenol come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is 2-Methoxy-4-propylphenol used outside industrial chemicals?
2-Methoxy-4-propylphenol also appears in cosmetics, pharmaceutical, cannabis databases.