Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
4 study endpoints found for Dihydroeugenol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 300 mg/kg bw/day | oral | mouse | oral | REACH |
| NOAEL | 300 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 304 mg/kg bw/day | oral | - | oral | REACH |
| NOAEL | 304 mg/kg bw/day | oral | - | oral | REACH |
Expert Verdict
Fragrance allergen with moderate sensitization potential; cross-reactivity with eugenol and isoeugenol possible; subject to EU allergen labeling requirements and IFRA use-level restrictions.
Regulatory Flags
Frequently Asked Questions
Is Dihydroeugenol safe in cosmetics?
Fragrance allergen with moderate sensitization potential; cross-reactivity with eugenol and isoeugenol possible; subject to EU allergen labeling requirements and IFRA use-level restrictions. The EU classifies Dihydroeugenol as "restricted". Safety rating: MODERATE. 4 toxicological study endpoint(s) are available in our database.
Is Dihydroeugenol allowed in the EU?
Dihydroeugenol EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does Dihydroeugenol do in cosmetics?
Dihydroeugenol functions as: Fragrance ingredient with spicy, clove-like character. It is classified as a cosmetic ingredient in our database. CAS number: 2785-87-7.
What is the Margin of Safety for Dihydroeugenol?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Dihydroeugenol?
The NOAEL (No Observed Adverse Effect Level) for Dihydroeugenol is 300 mg/kg bw/day based on a oral study via oral route in mouse. A total of 4 study endpoints are available. Source: REACH.
Compliance Tools
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Related Ingredients
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