Is Dihydroeugenol safe in cosmetics?
Dihydroeugenol has a safety rating of "MODERATE" in our database. EU status: restricted. US status: permitted. 2 toxicological study endpoint(s) are available in our database.
Dihydroeugenol
Also known as: Phenol, 2-methoxy-4-propyl-, 4-06-00-05976, BRN 1866292, Cerulignol, Coerulignol (+14 more)
INCI: DIHYDROEUGENOL
Dihydroeugenol (CAS 2785-87-7) is a cosmetic cosmetic ingredient functioning as Fragrance ingredient with spicy, clove-like character. NOAEL 300 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: restricted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 2785-87-7 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance ingredient with spicy, clove-like character
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
2-methoxy-4-propylphenol
InChIKey
PXIKRTCSSLJURC-UHFFFAOYSA-N
Regulatory Status
EU EU Status
restricted
US US Status
permitted
US Notes
Permitted with no specific CFR restriction; FEMA GRAS for flavor use
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Dihydroeugenol.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Dihydroeugenol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =67 mg/kg bw/day | oral: unspecified | Rat | subchronic | EFSA_OpenFoodTox_OpenFoodToxTX22809_2023.xlsx |
| NOAEL | =67 mg/kg bw/day | oral: unspecified | Rat | subchronic | EFSA_OpenFoodTox_OpenFoodToxTX22809_2023.xlsx |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Dihydroeugenol across SCCS product categories, with measured dermal absorption where available.
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
DPRA Cys %
0%
DPRA Lys %
12.3%
KeratinoSens IC50
759.166 µM
LLNA EC3
6.8%
NESIL
5400 µg/cm²
LLNA: Moderate (1B)
GHS: 1B
Human: positive
Source: LLNA: Gerberick et al. (2005); DPRA: Urbisch et al. 2015 [DOI:10.1016/j.yrtph.2014.12.008]; KS: Urbisch et al. 2015 [DOI:10.1016/j.yrtph.2014.12.008]; HPPT: [197] Kligman AM (1977): Report to RIFM, 3 November, unpublished.
HRIPT Human Patch Test Studies
2 human repeat insult patch tests aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HRIPT | 107 | 0 | 1772 | 1772 | non-sensitizer |
| HMT | - | 0 | 5400 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Carcinogen Classification
No indication of carcinogenicity (not listed by IARC). (L135)
Source: Toxin and Toxin Target Database (T3DB)
Regulatory (6)
JECFA Number
717
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
2-METHOXY-4-PROPYLPHENOL | 2000 | No safety concern at current levels of intake when used as a flavouring agent | TRS 901-JECFA 55/44 | FAS 46-JECFA 55/165
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
DIHYDROEUGENOL | 2000 | No safety concern at current levels of intake when used as a flavouring agent | TRS 901-JECFA 55/44 | FAS 46-JECFA 55/165
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
4-PROPYLGUAIACOL | 2000 | No safety concern at current levels of intake when used as a flavouring agent | TRS 901-JECFA 55/44 | FAS 46-JECFA 55/165
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
4-PROPYL-o-METHOXYPHENOL | 2000 | No safety concern at current levels of intake when used as a flavouring agent | TRS 901-JECFA 55/44 | FAS 46-JECFA 55/165
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Dihydroeugenol.
Regulatory Flags
potential-allergen
fragrance-component
ifra_fragrance
fda_food_additive
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Dihydroeugenol by CAS number or substance name.
Studies
2
Lowest NOAEL
67 mg/kg bw/day
Highest NOAEL
67 mg/kg bw/day
EFSA_OpenFoodTox_OpenFoodToxTX22809_2023.xlsx
Known Synonyms
Phenol, 2-methoxy-4-propyl-
4-06-00-05976
BRN 1866292
Cerulignol
Coerulignol
EINECS 220-499-0
FEMA No. 3598
Guaiacol, 4-propyl-
Guaiacylpropane
1-(4-Hydroxy-3-methoxyphenyl)propane
(4-Hydroxy-3-methoxyphenyl)propane
4-Hydroxy-3-methoxypropylbenzene
NSC 53043
p-Propylguaiacol
p-n-Propylguaiacol
Propylguaiacol, p-
4-Propylguaiacol
5-Propyl-O-hydroxyanisole
1-Propyl-3-methoxy-4-hydroxybenzene
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
IFRA Transparency
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3186884
Frequently Asked Questions
Is Dihydroeugenol allowed in the EU?
Dihydroeugenol EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does Dihydroeugenol do in cosmetics?
Dihydroeugenol functions as: Fragrance ingredient with spicy, clove-like character. It is classified as a cosmetic ingredient in our database. CAS number: 2785-87-7.
What is the NOAEL for Dihydroeugenol?
The NOAEL (No Observed Adverse Effect Level) for Dihydroeugenol is =67 mg/kg bw/day based on a subchronic study via oral: unspecified route in Rat. A total of 2 study endpoints are available. Source: EFSA_OpenFoodTox_OpenFoodToxTX22809_2023.xlsx.
Is Dihydroeugenol used outside cosmetics?
Dihydroeugenol also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Dihydroeugenol compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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