What is the NOAEL for Etidronic acid?
Etidronic acid has 24 NOAEL studies in the database. The lowest reported value is 12 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Etidronic acid
Also known as: Phosphonic acid, (1-hydroxyethylidene)bis-, 1,1,1-Ethanetriol diphosphonate, Phosphonic acid, P,P′-(1-hydroxyethylidene)bis-, 0-02-00-00171, BRN 1789291 (+15 more)
CAS 2809-21-4
Etidronic acid (CAS 2809-21-4) is a chemical substance. Key regulatory status: REACH registered, 8 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
Etidronic acid is classified GHS Danger (H290, H302, H314, H318, H413, H371) in the chemicals database but is restricted in EU cosmetics at max 1.5% in hair care products; 0.2% in soap.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
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noael studies public
NOAEL studies
24
SOURCE
chemical inventory jurisdictions
Regulatory lists
8
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
Etidronic acid
CAS Number
2809-21-4
DTXSID
DTXSID6023028
Molecular Formula
C2H8O7P2
InChI Key
DBVJJBKOTRCVKF-UHFFFAOYSA-N
Monoisotopic Mass
205.974527
Synonyms
Phosphonic acid, (1-hydroxyethylidene)bis-1,1,1-Ethanetriol diphosphonatePhosphonic acid, P,P′-(1-hydroxyethylidene)bis-0-02-00-00171BRN 1789291EINECS 220-552-8Hydroxyethane-1,1-diphosphonic acid(1-Hydroxyethylene)diphosphonic acid1-Hydroxyethylidene-1,1-biphosphonate(1-Hydroxyethylidene)diphoshonic acidPhosphonic acid, 1-hydroxy-1,1-ethanediyl esterUNII-M2F465ROXU
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
32 records
Chelating agentFragranceOxidizing agentStabilizing agentCorrosion inhibitorProcessing aids not otherwise specified
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
8 records
| List | Keyword | Source |
|---|---|---|
| Europe; Personal care; restricted | European Commission | CosIng |
| inert_ingredient; Pesticides | EPA | CPCat |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| pharmaceutical | US International Trade Commission | CPCat |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
| Canada; pharmaceutical | DrugBank | DrugBank |
| IFRA Transparency | IFRA | IFRA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 24 of 24 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =12 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| M2F465ROXU | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| M2F465ROXU | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| M2F465ROXU | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| M2F465ROXU | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =1 | mg/m3 | LOAEC | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| =12 | mg/m3 | LOAEC | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| =94 | mg/m3 | LOAEC | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| =169 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| >=0.5 | mg/m3 | NOAEL | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| 10 | mg/kg bw/day | NOAEL | oral | dog | COSMOS_DB |
| 75 | mg/kg bw/day | NOAEL | oral | dog | COSMOS_DB |
| 100 | mg/kg bw/day | NOAEL | oral | rabbit | COSMOS_DB |
| 250 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| >300 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| >330 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| 330.3 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| >=384 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| >=493 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| 500 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| >900 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| >2880 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_HESS |
| >300 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| >3000 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_ECHA_IUCLID |
Showing 24 of 24 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Etidronic acid | 220-552-8 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
1.5% in hair care products; 0.2% in soap
Category
chelating agent
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
ETIDRONIC ACID
ChEMBL Phase
4
Adverse Events
26
Bioactivity
6
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
1 food-safety record found.
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Etidronic acid?
Etidronic acid appears on 8 regulatory/inventory lists including Europe; Personal care; restricted, inert_ingredient; Pesticides, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), and 5 more. Source: EPA CPDat.
Is Etidronic acid used in cosmetics?
Yes, Etidronic acid is also indexed as a cosmetic ingredient under the name Etidronic Acid. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Etidronic acid come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Etidronic acid have different safety status in cosmetics vs industrial chemicals?
Etidronic acid is classified GHS Danger (H290, H302, H314, H318, H413, H371) in the chemicals database but is restricted in EU cosmetics at max 1.5% in hair care products; 0.2% in soap.
Is Etidronic acid used outside industrial chemicals?
Etidronic acid also appears in cosmetics, pharmaceutical, food safety, cannabis databases.