Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Etidronic Acid. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 75 mg/kg bw/day | oral | dog | Subchronic | COSMOS_DB |
| NOAEL | 250 mg/kg bw/day | oral | rat | Multigeneration Reproductive | COSMOS_DB |
| NOAEL | 100 mg/kg bw/day | oral | rabbit | Developmental | COSMOS_DB |
| NOAEL | 100 mg/kg bw/day | oral | rabbit | Developmental | COSMOS_DB |
| NOAEL | 500 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| NOAEL | 500 mg/kg bw/day | oral | rat | Carcinogenicity | COSMOS_DB |
| NOAEL | 250 mg/kg bw/day | oral | dog | Subchronic | COSMOS_DB |
| NOAEL | 250 mg/kg bw/day | oral | dog | Chronic | COSMOS_DB |
| NOAEL | 10 mg/kg bw/day | oral | dog | Chronic | COSMOS_DB |
| NOAEL | 500 mg/kg bw/day | oral | rat | Multigeneration Reproductive | COSMOS_DB |
Expert Verdict
Etidronic Acid and its salts are safe in cosmetics at present practices of use per CIR (2017). EU restricts to 1.5% in hair care and 0.2% in soap. Not genotoxic, carcinogenic, or teratogenic with very low dermal penetration, but poor biodegradability limits eco-certification eligibility.
Regulatory Flags
Frequently Asked Questions
Is Etidronic Acid safe in cosmetics?
Etidronic Acid and its salts are safe in cosmetics at present practices of use per CIR (2017). EU restricts to 1.5% in hair care and 0.2% in soap. Not genotoxic, carcinogenic, or teratogenic with very low dermal penetration, but poor biodegradability limits eco-certification eligibility. The EU classifies Etidronic Acid as "restricted". Safety rating: GOOD. 10 toxicological study endpoint(s) are available in our database.
Is Etidronic Acid allowed in the EU?
Etidronic Acid EU regulatory status: restricted. Maximum allowed concentration: 1.5% in hair care products; 0.2% in soap. This is based on EU Regulation 1223/2009 and its amendments.
What does Etidronic Acid do in cosmetics?
Etidronic Acid functions as: Chelating agent, perfume excipient. It is classified as a cosmetic ingredient in our database. CAS number: 2809-21-4.
What is the Margin of Safety for Etidronic Acid?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Etidronic Acid?
The NOAEL (No Observed Adverse Effect Level) for Etidronic Acid is 75 mg/kg bw/day based on a Subchronic study via oral route in dog. A total of 10 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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