What is the NOAEL for 6-Amino-m-cresol?
6-Amino-m-cresol has 8 NOAEL studies in the database. The lowest reported value is 200 mg/kg bw/d. Source: Regulatory source.
NOAEL Data
Cosmetic Ingredient
6-Amino-m-cresol
Also known as: EINECS 220-620-7, NSC 322874, UNII-QCG4ES2A26
CAS 2835-98-5
6-Amino-m-cresol (CAS 2835-98-5) is a chemical substance. Key regulatory status: 13 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, SCCS.
SOURCE
NOAEL studies
NOAEL studies
8
SOURCE
Chemical inventory jurisdictions
Regulatory lists
13
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
8 fields
Name
6-Amino-m-cresol
CAS Number
2835-98-5
Molecular Formula
C7H9NO
InChI Key
HCPJEHJGFKWRFM-UHFFFAOYSA-N
Monoisotopic Mass
123.068414
Synonyms
EINECS 220-620-7NSC 322874UNII-QCG4ES2A26
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
2 records
Dye
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
13 records
| List | Keyword | Source |
|---|---|---|
| Canada; Personal care; Substances in PCP - Canada (4/2014) | Government of Canada | CPCat |
| Europe; Personal care - hair coloring | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - hair coloring - hair color - professional | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - hair coloring - hair color - professional | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - hair coloring | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - hair coloring - hair color - professional | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - hair coloring - hair color - professional | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - hair coloring | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - hair coloring - hair color - permanent | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - hair coloring - hair color - professional | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - hair coloring | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - hair coloring | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - hair coloring | Danish Environmental Protection Agency | Danish EPA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 8 of 8 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 200 | mg/kg bw/d | - | - | - | Regulatory source |
| QCG4ES2A26 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =50 | mg/kg bw/d | NOAEL | oral | rat | SCCS Opinion |
| =200 | mg/kg bw/d | NOAEL | - | - | SCCS Opinion |
| =500 | mg/kg bw/d | NOAEL | - | rat | SCCS Opinion |
| 500 | mg/kg bw/d | genotoxicity | - | rat | Regulatory source |
| 50 | mg/kg bw/d | repeated dose toxicity | oral | rat | Regulatory source |
| 200 | mg/kg bw/d | repeated dose toxicity | - | rat | Regulatory source |
Showing 8 of 8 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
SCCS Opinions
EU Scientific Committee opinions tied to the matched substance.
SOURCE
SCCS Opinion
1 opinions
| Opinion | Date | Conclusion | Max Conc. | Concerns |
|---|---|---|---|---|
| SCCS/1400/11 | Adopted at 15th plenary meeting of 26-27 June 2012 | Therefore, the SCCS considers that 2-amino-5-methylphenol is not safe for consumers, when used in oxidative hair dye formulations with a concentration on the scalp of maximum 1.5% taking into account the scientific data provided. | 1.5% (on-scalp, oxidative hair dye) — assessed and found NOT safe | Not safe: 2-amino-5-methylphenol has genotoxic potential; metabolite N-acetyl-2-amino-5-methylphenol found in skin was genotoxic in in vitro micronucleus test; no adequate evidence of complete conversion to non-toxic metabolites in skin in vivo. Dimer formed under oxidative conditions absorbed by human skin; effects require further elucidation. |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Colorant
Frequently Asked Questions
What regulatory lists include 6-Amino-m-cresol?
6-Amino-m-cresol appears on 5 regulatory/inventory lists including Canada; Personal care; Substances in PCP - Canada (4/2014), Europe; Personal care - hair coloring, detected; Europe; Personal care - hair coloring - hair color - professional, and 2 more. Source: EPA CPDat.
Is 6-Amino-m-cresol used in cosmetics?
Yes, 6-Amino-m-cresol is also indexed as a cosmetic ingredient under the name 6-Amino-M-Cresol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 6-Amino-m-cresol come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.
Is 6-Amino-m-cresol used outside industrial chemicals?
6-Amino-m-cresol also appears in cosmetics databases.