Also known as: EINECS 220-620-7, NSC 322874, UNII-QCG4ES2A26
INCI: 6-AMINO-M-CRESOL
6-Amino-M-Cresol (CAS 2835-98-5) is a cosmetic cosmetic ingredient functioning as Hair colorant (oxidative and non-oxidative/semi-permanent hair dye). Reported NOAEL =50 mg/kg bw/d in rat (SCCS_vision_codex); EU Regulation 1223/2009 status: prohibited; 1 safety opinion reviewed (cir). Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 2835-98-5 →
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Margin of Safety, dermal absorption, and sensitization profile summaries for 6-Amino-M-Cresol.
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10 study endpoints found for 6-Amino-M-Cresol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =50 mg/kg bw/d | oral | rat | repeated dose toxicity | SCCS_vision_codex |
| NOAEL | =50 mg/kg bw/d | oral | rat | repeated dose toxicity | SCCS_vision_codex |
| NOAEL | =50 mg/kg bw/d | oral | rat | repeated dose toxicity | SCCS_vision_codex |
| NOAEL | =50 mg/kg bw/d | oral | rat | repeated dose toxicity | SCCS_vision_codex |
| NOAEL | =200 mg/kg bw/d | - | - | NOAEL study | SCCS_vision_codex |
| NOAEL | =200 mg/kg bw/d | - | - | NOAEL study | SCCS_vision_codex |
| NOAEL | =200 mg/kg bw/d | - | - | NOAEL study | SCCS_vision_codex |
| NOAEL | =200 mg/kg bw/d | - | - | NOAEL study | SCCS_vision_codex |
| NOAEL | =500 mg/kg bw/d | - | rat | genotoxicity | SCCS_vision_codex |
| NOAEL | =500 mg/kg bw/d | - | rat | genotoxicity | SCCS_vision_codex |
Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).
ata to determine the safety of this ingredient. The Panel concluded that the available data are insufficient to make a determination of safety for 6-Amino-m- Cresol under the intended conditions of use as a hair dye ingredient. INTRODUCTION 6-Amino-m-Cresol, which according to the web-based International
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
| Type | DA % | Method | Skin Model | SCCS Ref |
|---|---|---|---|---|
| measured | 5.1% | - | - | SCCS/0095 |
| measured | 0.59% | in_vitro | - | SCCS/0095 |
| measured | 14.25% | - | - | SCCS/0095 |
| measured | 74.48% | - | - | SCCS/0095 |
| measured | 82.78% | - | - | SCCS/0095 |
Expert safety assessment and concern-level summary for 6-Amino-M-Cresol.
Public NOAEL study rows linked to 6-Amino-M-Cresol by CAS number or substance name.
| Absorption % | Method | Vehicle |
|---|---|---|
| 5.1% | - | - |
| 0.59% | in_vitro | - |
| 14.25% | - | - |
| 74.48% | - | - |
| 82.78% | - | - |
6-Amino-M-Cresol has a safety rating of "POOR" in our database. EU status: prohibited. US status: restricted. 10 toxicological study endpoint(s) are available in our database. This ingredient has been reviewed by cir.
6-Amino-M-Cresol EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
6-Amino-M-Cresol functions as: Hair colorant (oxidative and non-oxidative/semi-permanent hair dye). It is classified as a cosmetic ingredient in our database. CAS number: 2835-98-5.
The NOAEL (No Observed Adverse Effect Level) for 6-Amino-M-Cresol is =50 mg/kg bw/d based on a repeated dose toxicity study via oral route in rat. A total of 10 study endpoints are available. Source: SCCS_vision_codex.
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