Also known as: 3-Aminomethyl-3,5,5-trimethyl-cyclohexylamine, EINECS 220-666-8
CAS 2855-13-2
Isophorone diamine (CAS 2855-13-2) is a chemical substance with GHS signal word Danger; key hazard signal: H302; H314; H318; H317. Key regulatory status: REACH registered, 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.
Isophorone diamine is classified GHS Danger (H302, H314, H318, H317) in the chemicals database but is allowed in EU cosmetics.
CAS, identifiers, formula, and alternate names for the matched substance record.
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Acute Tox. 4; Skin Corr. 1B; Eye Dam. 1; Skin Sens. 1A | H302; H314; H318; H317 | GHS07; GHS05 | Danger |
International Chemical Safety Card hazard and exposure summary.
| Field | Value |
|---|---|
| GHS Signal Word | DANGER |
| GHS Hazard Statements | Harmful if swallowed Causes severe skin burns and eye damage May cause an allergic skin reaction Harmful to aquatic life |
| Short-term Effects | The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. Inhalation of high concentrations may cause lung oedema, but only after initial corrosive effects on the eyes and the upper respiratory tract have become manifest. Medical observation is indicated. |
| Long-term Effects | Repeated or prolonged contact may cause skin sensitization. Repeated or prolonged inhalation may cause asthma. |
| Routes of Exposure | Serious local effects by all routes of exposure. |
Industrial and product-use categories associated with this substance.
Inventory, screening, and regulatory list matches from public chemical databases.
| List | Keyword | Source |
|---|---|---|
| drinking_water; Europe; manufacturing; plastic_additive | Belgaqua | CPCat |
| CEDI | FDA | United States Food and Drug Administration (FDA) |
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =0.073 | mg/m3 | DNEL local | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 1 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| X5WYA841BU | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| X5WYA841BU | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| X5WYA841BU | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| X5WYA841BU | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =50 | mg/kg bw/day | NOAEL | oral | Rabbit | ToxValDB_ECHA_IUCLID |
| =60 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_HESS |
| >75 | mg/kg bw/day | NOAEL | oral | Rabbit | ToxValDB_ECHA_IUCLID |
| =100 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =50 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_ECHA_IUCLID |
Showing 11 of 11 studies
Registration status from the ECHA REACH registered substances database.
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 3-aminomethyl-3,5,5-trimethylcyclohexylamine | 220-666-8 | ECHA overview → |
Australian industrial chemicals inventory status and applicable conditions.
Same-CAS cosmetic ingredient record for cross-vertical context.
Isophorone diamine (CAS 2855-13-2) is classified under EU CLP Annex VI as Acute Tox. 4; Skin Corr. 1B; Eye Dam. 1; Skin Sens. 1A with signal word Danger. Hazard statements: H302; H314; H318; H317. Source: EU CLP Annex VI (ECHA).
Isophorone diamine has 11 NOAEL studies in the database. The lowest reported value is 0.073 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
Isophorone diamine appears on 3 regulatory/inventory lists including drinking_water; Europe; manufacturing; plastic_additive, CEDI, Indirect additives food contact (10/2018). Source: EPA CPDat.
Yes, Isophorone diamine is also indexed as a cosmetic ingredient under the name Isophorone Diamine. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.
Isophorone diamine is classified GHS Danger (H302, H314, H318, H317) in the chemicals database but is allowed in EU cosmetics.
Isophorone diamine also appears in cosmetics databases.