Poor Cosmetic Ingredient NOAEL Data GHS Classified

Isophorone Diamine

INCI: ISOPHORONE DIAMINE

CAS Number
2855-13-2
Function
Not reported for cosmetic use (industrial epoxy curing agent)
Safety Rating
POOR

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Permitted — not on FDA prohibited/restricted lists; no specific CFR citation

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
high

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

2 study endpoints found for Isophorone Diamine. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
LOAEL 160 mg/kg bw/day oral rat oral REACH
NOAEL 100 mg/kg bw/day oral rat oral REACH

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Signal Word
DANGER
Pictograms
corr; excl mark;warn
Hazard Statements
Harmful if swallowed Causes severe skin burns and eye damage May cause an allergic skin reaction Harmful to aquatic life
Short-term Exposure Effects
The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. Inhalation of high concentrations may cause lung oedema, but only after initial corrosive effects on the eyes and the upper respiratory tract have become manifest. Medical observation is indicated.
Long-term Exposure Effects
Repeated or prolonged contact may cause skin sensitization. Repeated or prolonged inhalation may cause asthma.
Routes of Exposure
Serious local effects by all routes of exposure.

Expert Verdict

Strong skin and respiratory sensitizer with corrosive classification; used in epicutaneous allergy testing as a known allergen.

⚠️
Concern Level: High

Regulatory Flags

potential-allergen

Frequently Asked Questions

Is Isophorone Diamine safe in cosmetics?

Strong skin and respiratory sensitizer with corrosive classification; used in epicutaneous allergy testing as a known allergen. The EU classifies Isophorone Diamine as "permitted". Safety rating: POOR. 2 toxicological study endpoint(s) are available in our database.

Is Isophorone Diamine allowed in the EU?

Isophorone Diamine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Isophorone Diamine do in cosmetics?

Isophorone Diamine functions as: Not reported for cosmetic use (industrial epoxy curing agent). It is classified as a cosmetic ingredient in our database. CAS number: 2855-13-2.

What is the Margin of Safety for Isophorone Diamine?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Isophorone Diamine?

The NOAEL (No Observed Adverse Effect Level) for Isophorone Diamine is 160 mg/kg bw/day based on a oral study via oral route in rat. A total of 2 study endpoints are available. Source: REACH.

Is Isophorone Diamine classified as hazardous under GHS?

Isophorone Diamine carries a GHS signal word of "DANGER". Hazard statements: Harmful if swallowed Causes severe skin burns and eye damage May cause an allergic skin reaction Harmful to aquatic life. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.

Compliance Tools

Check Isophorone Diamine compliance across multiple jurisdictions:

🔬
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
 🧪
Substance Compliance
Check compliance across 55 jurisdictions
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
 ⚗️
Heavy Metal Limits
Compare limits across jurisdictions

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