NOAEL Data IARC Group 3 REACH Registered Cosmetic Ingredient

HC Red 3

Also known as: BRN 2110120, EINECS 220-701-7, NCI-C54922, N(sup 1)-(2-Hydroxyethyl)-2-nitro-p-phenylenediamine, UNII-51CPX7M1SQ (+1 more)

CAS 2871-01-4

HC Red 3 (CAS 2871-01-4) is a chemical substance; key hazard signal: IARC Group 3. Key regulatory status: REACH registered, 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, SCCS, IARC, ECHA REACH.

View cosmetic safety profile for HC Red No. 3 →

Cross-Vertical Regulatory Divergence

HC Red 3 is prohibited in EU cosmetics at max 3.0% but has active industrial GHS classifications (H315, H317, H319, H335, H411).

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code

SOURCE NOAEL studies

NOAEL studies

SOURCE Chemical inventory jurisdictions

Regulatory lists

SOURCE EU CLP Annex VI

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 11 fields

Name

HC Red 3

CAS Number

2871-01-4

Molecular Formula

C8H11N3O3

InChI Key

GZGZVOLBULPDFD-UHFFFAOYSA-N

Monoisotopic Mass

197.080041

Synonyms

BRN 2110120EINECS 220-701-7NCI-C54922N(sup 1)-(2-Hydroxyethyl)-2-nitro-p-phenylenediamineUNII-51CPX7M1SQ2-[(4-Amino-2-nitrophenyl)amino]-ethanol

IARC Carcinogen Classification

Carcinogenic hazard classification from IARC monograph evaluations.

SOURCE IARC Monographs on the Identification of Carcinogenic Hazards to Humans 1 records

Group	Meaning	Evaluated	Volume
Group 3	Not classifiable	1992	57

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 4 records

Dye

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 3 records

List	Keyword	Source
Europe; Personal care - hair coloring	Danish Environmental Protection Agency	Danish EPA
children; Europe; Personal care	Danish Environmental Protection Agency	Danish EPA
children; Europe; Personal care	Danish Environmental Protection Agency	Danish EPA

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 27 of 27 studies

Value	Unit	Endpoint	Route	Species	Source
0.02	%	-	oral	mouse	Regulatory source
97.5	-	-	-	-	Regulatory source
125	mg/kg bw/d	-	-	rat	Regulatory source
250	mg/kg bw/d	-	oral	rat	Regulatory source
250	mg/kg bw/d	-	-	rat	Regulatory source
2.2	%	EC3	Dermal	Mouse	NTP ICE skin sensitization
51CPX7M1SQ	UNII	FDA UNII substance identifier	-	-	openFDA substances
3	IARC group	IARC carcinogenicity classification	-	-	IARC Monographs
3	unitless	IARC group	-	-	NTP ICE cancer
>1000	mg/kg bw	LD50	oral	Rat	NTP ICE acute oral
15	mg/kg bw/day	LOAEL	oral	mouse	COSMOS DB
=0.003	mg/kg bw	NOAEL	oral	mouse	SCCS Opinion
=0.01	mg/kg bw	NOAEL	oral	mouse	SCCS Opinion
=0.015	mg/kg bw	NOAEL	oral	mouse	SCCS Opinion
=0.02	%	NOAEL	oral	mouse	SCCS Opinion
=45	mg/kg bw/d	NOAEL	oral	mouse	SCCS Opinion
=50	%	NOAEL	oral	mouse	SCCS Opinion
=90	mg/kg bw/d	NOAEL	oral	mouse	SCCS Opinion
=97.5	-	NOAEL	-	-	SCCS Opinion
=125	mg/kg bw/d	NOAEL	-	rat	SCCS Opinion
=200	mg/kg bw/day	NOAEL	oral	Rat	ECHA
=200	mg/kg/d	NOAEL	oral	rabbit	SCCS Opinion
=200	mg/kg bw/d	NOAEL	oral	rabbit	SCCS Opinion
>250	mg/kg bw/day	NOAEL	oral	Mouse	ECHA
=250	mg/kg bw/d	NOAEL	oral	rat	SCCS Opinion
>500	mg/kg bw/day	NOAEL	oral	Mouse	ECHA
=500	mg/kg bw/d	NOAEL	oral	rat	SCCS Opinion

Showing 27 of 27 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA 1 records

Status	Name	EC Number	Link
Registered	2-(4-amino-2-nitroanilino)ethanol	220-701-7	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE SCCS Opinion 2 opinions

Opinion	Date	Conclusion	Max Conc.	Concerns
SCCS/1417/10	14 December 2010	insufficient data	-	sensitisation data inadequate; genotoxicity unresolved
SCCS/1293/10	2010-12-14	Based on the data provided, the SCCS is of the opinion that the use of HC Red n° 3 as a non-oxidative hair dye with a maximum on-head concentration of 3.0% does not pose a risk to the health of the consumer, apart from its sensitising potential.	3.0% maximum on-head (non-oxidative hair dye)	HC Red n° 3 is an extreme contact sensitiser in the GPMT and a strong sensitiser in the LLNA; safe apart from its sensitising potential. Secondary amine prone to nitrosation; must not be used with nitrosating substances; nitrosamine content < 50 ppb.

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

prohibited

Max

3.0%

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE ChEMBL / DailyMed CHEMBL3185903

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Frequently Asked Questions

What is the NOAEL for HC Red 3?

HC Red 3 has 27 NOAEL studies in the database. The lowest reported value is 0.003 mg/kg bw via oral in mouse. Source: SCCS Opinion.

What regulatory lists include HC Red 3?

HC Red 3 appears on 2 regulatory/inventory lists including Europe; Personal care - hair coloring, children; Europe; Personal care. Source: EPA CPDat.

Is HC Red 3 a carcinogen according to IARC?

HC Red 3 is classified by IARC as Group 3 — not classifiable as to its carcinogenicity to humans (evaluated 1992). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.

Is HC Red 3 used in cosmetics?

Yes, HC Red 3 is also indexed as a cosmetic ingredient under the name HC Red No. 3. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for HC Red 3 come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, IARC Monographs, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Does HC Red 3 have different safety status in cosmetics vs industrial chemicals?

HC Red 3 is prohibited in EU cosmetics at max 3.0% but has active industrial GHS classifications (H315, H317, H319, H335, H411).

Is HC Red 3 used outside industrial chemicals?

HC Red 3 also appears in cosmetics, pharmaceutical databases.