HC Red No. 3
INCI: HC RED NO. 3
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
6 study endpoints found for HC Red No. 3. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| LOAEL | 15 mg/kg bw/day | oral | mouse | Subchronic | COSMOS_DB |
| NOAEL | 250 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | >500 mg/kg bw/day | oral | mouse | oral | REACH |
| NOAEL | 1000 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | >250 mg/kg bw/day | oral | mouse | oral | REACH |
| NOAEL | 90 mg/kg bw/day | oral | - | - | SCCS_Perplexity |
Safety Opinions
Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).
Sensitization Profile
Contact sensitization data for HC Red No. 3 based on clinical patch test studies and IFRA standards.
Source: IVDK; NACDG; ESSCA
Expert Verdict
Secondary amine prone to nitrosation; must not be used with nitrosating agents. Nitrosamine content must be <50 ppb. Unidentified nitrosamines found in some commercial lots (20 ± 5 ppm, 11 ± 8 ppm). Carcinogenicity studies show one negative and one inadequate result.
Regulatory Flags
Frequently Asked Questions
Is HC Red No. 3 safe in cosmetics?
Secondary amine prone to nitrosation; must not be used with nitrosating agents. Nitrosamine content must be <50 ppb. Unidentified nitrosamines found in some commercial lots (20 ± 5 ppm, 11 ± 8 ppm). Carcinogenicity studies show one negative and one inadequate result. The EU classifies HC Red No. 3 as "prohibited". Safety rating: MODERATE. 6 toxicological study endpoint(s) are available in our database. This ingredient has been reviewed by cir.
Is HC Red No. 3 allowed in the EU?
HC Red No. 3 EU regulatory status: prohibited. Maximum allowed concentration: 3.0%. This is based on EU Regulation 1223/2009 and its amendments.
What does HC Red No. 3 do in cosmetics?
HC Red No. 3 functions as: Non-oxidative (semi-permanent) and oxidative hair dye. It is classified as a cosmetic ingredient in our database. CAS number: 2871-01-4.
What is the Margin of Safety for HC Red No. 3?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for HC Red No. 3?
The NOAEL (No Observed Adverse Effect Level) for HC Red No. 3 is 15 mg/kg bw/day based on a Subchronic study via oral route in mouse. A total of 6 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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