Also known as: BRN 2110120, EINECS 220-701-7, NCI-C54922, N(sup 1)-(2-Hydroxyethyl)-2-nitro-p-phenylenediamine, UNII-51CPX7M1SQ (+1 more)
INCI: HC RED NO. 3
HC Red No. 3 (CAS 2871-01-4) is a cosmetic cosmetic ingredient functioning as Non-oxidative (semi-permanent) and oxidative hair dye. NOAEL 200 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: prohibited, max 3.0%; 1 safety opinion reviewed (cir). Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 2871-01-4 →
HC Red No. 3 is prohibited in EU cosmetics at max 3.0% but has active industrial GHS classifications (H315, H317, H319, H335, H411).
Source: Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Margin of Safety, dermal absorption, and sensitization profile summaries for HC Red No. 3.
Calculate MoS for your specific formulation with the MoS Calculator.
10 study endpoints found for HC Red No. 3. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =0.003 mg/kg bw | oral | mouse | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.003 mg/kg bw | oral | mouse | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.003 mg/kg bw | oral | mouse | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.003 mg/kg bw | oral | mouse | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.01 mg/kg bw | oral | mouse | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.01 mg/kg bw | oral | mouse | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.01 mg/kg bw | oral | mouse | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.01 mg/kg bw | oral | mouse | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.015 mg/kg bw | oral | mouse | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.015 mg/kg bw | oral | mouse | dermal absorption | SCCS_vision_codex |
Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).
Pre-calculated NOAEL → SED → MoS audit trail for HC Red No. 3 across SCCS product categories, with measured dermal absorption where available.
Contact sensitization data for HC Red No. 3 based on clinical patch test studies and IFRA standards.
Source: IVDK; NACDG; ESSCA
International Agency for Research on Cancer (WHO) monograph evaluation.
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
Source: LLNA: CosmEur database; DPRA: Cosmetics Europe; KS: Cosmetics Europe; hCLAT: Cosmetics Europe
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| CN | permitted_hair_dye | 1 | Non-oxidative hair dye (direct) |
| BR | permitted_hair_dye | - | Direct/non-oxidative hair dye |
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
Source: Roberts_Cheruvu_Mendeley_2022
| Type | DA % | Method | Skin Model | SCCS Ref |
|---|---|---|---|---|
| measured | 98.7% | - | - | SCCS/0043 |
| measured | 2.0% | - | - | SCCS/0043 |
| measured | 0.072% | - | - | SCCS/0043 |
| measured | 0.101% | - | - | SCCS/0043 |
| measured | 0.173% | - | - | SCCS/0043 |
2 property records from structured ingredient metadata.
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Expert safety assessment and concern-level summary for HC Red No. 3.
Public NOAEL study rows linked to HC Red No. 3 by CAS number or substance name.
Units vary across source rows: mg/kg bw/day, mg/kg bw/d, mg/kg/d
| Absorption % | Method | Vehicle |
|---|---|---|
| 98.7% | - | - |
| 2.0% | - | - |
| 0.072% | - | - |
| 0.101% | - | - |
| 0.173% | - | - |
Same-CAS public records found in pharmaceutical data.
Same-CAS rows from the pharmaceutical spoke database.
HC Red No. 3 has a safety rating of "MODERATE" in our database. EU status: prohibited. US status: permitted. 10 toxicological study endpoint(s) are available in our database. This ingredient has been reviewed by cir.
HC Red No. 3 EU regulatory status: prohibited. Maximum allowed concentration: 3.0%. This is based on EU Regulation 1223/2009 and its amendments.
HC Red No. 3 functions as: Non-oxidative (semi-permanent) and oxidative hair dye. It is classified as a cosmetic ingredient in our database. CAS number: 2871-01-4.
The NOAEL (No Observed Adverse Effect Level) for HC Red No. 3 is =0.003 mg/kg bw based on a dermal absorption study via oral route in mouse. A total of 10 study endpoints are available. Source: SCCS_vision_codex.
HC Red No. 3 also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
HC Red No. 3 is prohibited in EU cosmetics at max 3.0% but has active industrial GHS classifications (H315, H317, H319, H335, H411).
Check HC Red No. 3 compliance across multiple jurisdictions:
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