NOAEL Data Cosmetic Ingredient

1,2-Propanediol monobutyl ether

Also known as: Butoxypropanol, Propanol, 1(or 2)-butoxy-, Propylene glycol monobutyl ether, Propylene glycol n-butyl ether, DBG (+10 more)

CAS 29387-86-8

1,2-Propanediol monobutyl ether (CAS 29387-86-8) is a chemical substance. Key regulatory status: 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.

View cosmetic safety profile for Isobutoxypropanol →

SOURCE NOAEL studies

NOAEL studies

SOURCE Chemical inventory jurisdictions

Regulatory lists

SOURCE EU CLP Annex VI

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 17 fields

Name

1,2-Propanediol monobutyl ether

CAS Number

29387-86-8

Synonyms

ButoxypropanolPropanol, 1(or 2)-butoxy-Propylene glycol monobutyl etherPropylene glycol n-butyl etherDBGBFDG1(or 2)-Butoxypropanol1,2-Propanediol, monobutyl etherbutoxipropanolbutossipropanolobutoksipropanoli1-Butoxy-2-hydroxypropane

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 17 records

SolventCleaning agentDrierAbrasiveSolubility enhancerChemical reaction regulator

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 2 records

List	Keyword	Source
Cleaning products and household care; Europe	Danish EPA	Danish EPA
inert_ingredient; non_food_use; Pesticides	EPA	CPCat

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 37 of 37 studies

Value	Unit	Endpoint	Route	Species	Source
1.76	mg/kg bw/day	-	dermal	rabbit	Regulatory source
10	mg/kg bw/day	-	dermal	rabbit	Regulatory source
>3785	mg/m3	-	-	rat	Regulatory source
6X8776AP5Z	UNII	FDA UNII substance identifier	-	-	openFDA substances
0	unitless	Model Score	-	-	NTP ICE endocrine
=0	mg/ m3	NOAEL	oral	rat	CIR Safety Assessment
=0.047	g/kg/d	NOAEL	oral	rat	CIR Safety Assessment
=0.5	g/kg/d	NOAEL	oral	rat	CIR Safety Assessment
=1.76	mg/kg bw/day	NOAEL	dermal	rabbit	CIR Safety Assessment
=10	mg/kg bw/day	NOAEL	dermal	rabbit	CIR Safety Assessment
=91	mg/kg/day	NOAEL	oral	rat	CIR Safety Assessment
=100	mg/kg bw/day	NOAEL	oral	rat	CIR Safety Assessment
>100	mg/ kg bw/day	NOAEL	-	rat	CIR Safety Assessment
=100	mg/kg bw/d	NOAEL	oral	rat	CIR Safety Assessment
=200	mg/m3	NOAEL	inhalation	rat	CIR Safety Assessment
=320	mg/m3	NOAEL	inhalation	rat	CIR Safety Assessment
=350	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB HESS
=350	mg/kg bw	NOAEL	oral	rat	CIR Safety Assessment
=400	mg/kg bw	NOAEL	oral	rat	CIR Safety Assessment
=450	mg/kg	NOAEL	oral	rat	CIR Safety Assessment
=500	mg/kg/day	NOAEL	oral	rat	CIR Safety Assessment
>750	mg/kg	NOAEL	oral	rat	CIR Safety Assessment
=880	mg/kg bw	NOAEL	inhalation	rat	CIR Safety Assessment
=1000	mg/kg bw	NOAEL	oral	rat	CIR Safety Assessment
=3244	mg/m3	NOAEL	inhalation	rat	CIR Safety Assessment
>3785	mg/m3	NOAEL	-	rat	CIR Safety Assessment
6	kiloohms	TER	Dermal	-	NTP ICE skin irritation
7.1	kiloohms	TER	Dermal	-	NTP ICE skin irritation
0	mg/ m3	developmental toxicity	oral	rat	Regulatory source
>100	mg/ kg bw/day	developmental toxicity	-	rat	Regulatory source
<=100	mg/kg bw/d	developmental toxicity	oral	rat	Regulatory source
3244	mg/m3	inhalation toxicity	inhalation	rat	Regulatory source
91	mg/kg/day	oral toxicity	oral	rat	Regulatory source
350	mg/kg bw	oral toxicity	oral	rat	Regulatory source
400	mg/kg bw	oral toxicity	oral	rat	Regulatory source
450	mg/kg	oral toxicity	oral	rat	Regulatory source
>750	mg/kg	oral toxicity	oral	rat	Regulatory source

Showing 37 of 37 studies

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

prohibited

Max

Frequently Asked Questions

What is the NOAEL for 1,2-Propanediol monobutyl ether?

1,2-Propanediol monobutyl ether has 37 NOAEL studies in the database. The lowest reported value is 1.76 mg/kg bw/day via dermal in rabbit. Source: Regulatory source.

What regulatory lists include 1,2-Propanediol monobutyl ether?

1,2-Propanediol monobutyl ether appears on 2 regulatory/inventory lists including Cleaning products and household care; Europe, inert_ingredient; non_food_use; Pesticides. Source: EPA CPDat.

Is 1,2-Propanediol monobutyl ether used in cosmetics?

Yes, 1,2-Propanediol monobutyl ether is also indexed as a cosmetic ingredient under the name Isobutoxypropanol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 1,2-Propanediol monobutyl ether come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.

Is 1,2-Propanediol monobutyl ether used outside industrial chemicals?

1,2-Propanediol monobutyl ether also appears in cosmetics databases.