Is Isobutoxypropanol safe in cosmetics?
Isobutoxypropanol has a safety rating of "MODERATE" in our database. EU status: prohibited. US status: permitted. 10 toxicological study endpoint(s) are available in our database.
Isobutoxypropanol
Also known as: Butoxypropanol, Propanol, 1(or 2)-butoxy-, Propylene glycol monobutyl ether, Propylene glycol n-butyl ether, DBG (+10 more)
INCI: ISOBUTOXYPROPANOL
Isobutoxypropanol (CAS 29387-86-8) is a cosmetic cosmetic ingredient functioning as Solvent. Reported NOAEL =1.76 mg/kg bw/day in rabbit (CIR_vision_codex); EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 29387-86-8 →
Auto-generated CPSR Part A draft with source citations
Function
Solvent
Safety Rating
MODERATE
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
Permitted — no specific CFR restriction
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Isobutoxypropanol.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Isobutoxypropanol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =1.76 mg/kg bw/day | dermal | rabbit | NOAEL study | CIR_vision_codex |
| NOAEL | =1.76 mg/kg bw/day | dermal | rabbit | NOAEL study | CIR_vision_codex |
| NOAEL | =1.76 mg/kg bw/day | dermal | rabbit | NOAEL study | CIR_vision_codex |
| NOAEL | =1.76 mg/kg bw/day | dermal | rabbit | NOAEL study | CIR_vision_codex |
| NOAEL | =10 mg/kg bw/day | dermal | rabbit | NOAEL study | CIR_vision_codex |
| NOAEL | =10 mg/kg bw/day | dermal | rabbit | NOAEL study | CIR_vision_codex |
| NOAEL | =10 mg/kg bw/day | dermal | rabbit | NOAEL study | CIR_vision_codex |
| NOAEL | =10 mg/kg bw/day | dermal | rabbit | NOAEL study | CIR_vision_codex |
| NOAEL | =91 mg/kg/day | oral | rat | oral toxicity | CIR_vision_codex |
| NOAEL | =91 mg/kg/day | oral | rat | oral toxicity | CIR_vision_codex |
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Abrasive
Chemical reaction regulator
Cleaning agent
Drier
Solubility enhancer
Solvent
Expert Verdict
Expert safety assessment and concern-level summary for Isobutoxypropanol.
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Isobutoxypropanol by CAS number or substance name.
Studies
40
Lowest NOAEL
1.76
Highest NOAEL
1000
Units vary across source rows: mg/kg bw, mg/kg bw/day, mg/kg/day
CIR_vision_codex
Known Synonyms
Butoxypropanol
Propanol, 1(or 2)-butoxy-
Propylene glycol monobutyl ether
Propylene glycol n-butyl ether
DBG
BFDG
1(or 2)-Butoxypropanol
1,2-Propanediol, monobutyl ether
butoxipropanol
butossipropanolo
butoksipropanoli
1-Butoxy-2-hydroxypropane
EINECS 249-598-7
alpha-Propylene mono-n-butyl ether
UNII-6X8776AP5Z
Chemical Function
Solvent
Cleaning agent
Drier
Abrasive
Solubility enhancer
Regulatory Lists
Cleaning products and household care; Europe
inert_ingredient; non_food_use; Pesticides
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Isobutoxypropanol allowed in the EU?
Isobutoxypropanol EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Isobutoxypropanol do in cosmetics?
Isobutoxypropanol functions as: Solvent. It is classified as a cosmetic ingredient in our database. CAS number: 29387-86-8.
What is the NOAEL for Isobutoxypropanol?
The NOAEL (No Observed Adverse Effect Level) for Isobutoxypropanol is =1.76 mg/kg bw/day based on a NOAEL study study via dermal route in rabbit. A total of 10 study endpoints are available. Source: CIR_vision_codex.
Compliance Tools
Check Isobutoxypropanol compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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