NOAEL Data Cosmetic Ingredient

5,6-Dihydroxyindoline

Also known as: 1H -Indole-5,6-diol, 2,3-dihydro-, 2,3-Dihydro-1H -indole-5,6-diol, 5,6-Indolinediol, Leucodopaminochrome

CAS 29539-03-5

5,6-Dihydroxyindoline (CAS 29539-03-5) is a chemical substance. Key regulatory status: cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat.

View cosmetic safety profile for Dihydroxyindoline →

SOURCE NOAEL studies

NOAEL studies

SOURCE Chemical inventory jurisdictions

Regulatory lists

SOURCE EU CLP Annex VI

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 9 fields

Name

5,6-Dihydroxyindoline

CAS Number

29539-03-5

Molecular Formula

C8H9NO2

InChI Key

VGSVNUGKHOVSPK-UHFFFAOYSA-N

Monoisotopic Mass

151.063329

Synonyms

1H -Indole-5,6-diol, 2,3-dihydro-2,3-Dihydro-1H -indole-5,6-diol5,6-IndolinediolLeucodopaminochrome

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 2 records

Dye

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 17 of 17 studies

Value	Unit	Endpoint	Route	Species	Source
20	mg/kg bw/day	-	-	rat	Regulatory source
180	mg/kg bw/day	-	-	rat	Regulatory source
HH49N58FJ9	UNII	FDA UNII substance identifier	-	-	openFDA substances
20	mg/kg bw/day	LOAEL	oral	rat	COSMOS DB
=2	%	NOAEL	oral	rat	SCCNFP Opinion
10	mg/kg bw/day	NOAEL	oral	rat	COSMOS DB
=10	mg/kg/day	NOAEL	dermal	rat	SCCNFP Opinion
=10	mg/kg	NOAEL	oral	rat	SCCNFP Opinion
=10	mg/kg bw/day	NOAEL	oral	rat	SCCNFP Opinion
=20	mg/kg bw/day	NOAEL	-	rat	SCCNFP Opinion
=180	mg/kg bw/day	NOAEL	-	rat	SCCNFP Opinion
=240	mg/kg bw/day	NOAEL	dermal	rat	SCCNFP Opinion
=10	mg/kg	dermal absorption	oral	rat	Regulatory source
240	mg/kg bw/day	dermal absorption	dermal	rat	Regulatory source
2	%	repeated dose toxicity	oral	rat	Regulatory source
10	mg/kg/day	repeated dose toxicity	dermal	rat	Regulatory source
10	mg/kg bw/day	repeated dose toxicity	oral	rat	Regulatory source

Showing 17 of 17 studies

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

restricted

Max

Frequently Asked Questions

What is the NOAEL for 5,6-Dihydroxyindoline?

5,6-Dihydroxyindoline has 17 NOAEL studies in the database. The lowest reported value is 20 mg/kg bw/day in rat. Source: Regulatory source.

Is 5,6-Dihydroxyindoline used in cosmetics?

Yes, 5,6-Dihydroxyindoline is also indexed as a cosmetic ingredient under the name Dihydroxyindoline. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 5,6-Dihydroxyindoline come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.

Is 5,6-Dihydroxyindoline used outside industrial chemicals?

5,6-Dihydroxyindoline also appears in cosmetics databases.