Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Dihydroxyindoline. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 10 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| LOAEL | 20 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
Expert Verdict
Annex III restrictions on max concentration; mandatory patch test warning; non-oxidative use only at entry 204
Frequently Asked Questions
Is Dihydroxyindoline safe in cosmetics?
Annex III restrictions on max concentration; mandatory patch test warning; non-oxidative use only at entry 204 The EU classifies Dihydroxyindoline as "restricted". Safety rating: GOOD. 2 toxicological study endpoint(s) are available in our database.
Is Dihydroxyindoline allowed in the EU?
Dihydroxyindoline EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does Dihydroxyindoline do in cosmetics?
Dihydroxyindoline functions as: Hair dyeing — non-oxidative direct dye (melanin precursor). It is classified as a cosmetic ingredient in our database. CAS number: 29539-03-5.
What is the Margin of Safety for Dihydroxyindoline?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Dihydroxyindoline?
The NOAEL (No Observed Adverse Effect Level) for Dihydroxyindoline is 10 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 2 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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