What is the NOAEL for Amygdalin?
Amygdalin has 10 NOAEL studies in the database. The lowest reported value is 0.02 mg/kg bw in Consumers. Source: EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx.
NOAEL Data
Cosmetic Ingredient
Amygdalin
Also known as: Benzeneacetonitrile, α-[(6-O-β-D-glucopyranosyl-β-D-glucopyranosyl)oxy]-, (αR)-, Benzeneacetonitrile, α-[(6-O-β-D-glucopyranosyl-β-D-glucopyranosyl)oxy]-, (R)-, (αR)-α-[(6-O-β-D-Glucopyranosyl-β-D-glucopyranosyl)oxy]benzeneacetonitrile, D-Amygdalin, Mandelonitrile-β-gentiobioside (+5 more)
CAS 29883-15-6
Amygdalin (CAS 29883-15-6) is a chemical substance. Key regulatory status: cosmetic ingredient cross-reference; source data from EPA ToxValDB, AICIS.
Cross-Vertical Regulatory Divergence
Amygdalin is prohibited in EU cosmetics but has active industrial GHS classifications (H302).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
10
SOURCE
chemical inventory jurisdictions
Regulatory lists
0
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
16 fields
Name
Amygdalin
CAS Number
29883-15-6
DTXSID
DTXSID00897159
Molecular Formula
C20H27NO11
InChI Key
XUCIJNAGGSZNQT-JHSLDZJXSA-N
Monoisotopic Mass
457.158411
Synonyms
Benzeneacetonitrile, α-[(6-O-β-D-glucopyranosyl-β-D-glucopyranosyl)oxy]-, (αR)-Benzeneacetonitrile, α-[(6-O-β-D-glucopyranosyl-β-D-glucopyranosyl)oxy]-, (R)-(αR)-α-[(6-O-β-D-Glucopyranosyl-β-D-glucopyranosyl)oxy]benzeneacetonitrileD-AmygdalinMandelonitrile-β-gentiobioside(R)-AmygdalinNSC 15780(-)-AmygdalinAmygdalosideAmygdaloside (disaccharide)
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 10 of 10 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =0.02 | mg/kg bw | ARfD | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| =0.02 | mg/kg bw | ARfD | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| =20 | µg/kg bw | ARfD | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| =20 | µg/kg bw | ARfD | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| 214UUQ9N0H | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 214UUQ9N0H | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 214UUQ9N0H | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 214UUQ9N0H | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =0.105 | mg/kg bw | NOAEL | - | Human | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =0.105 | mg/kg bw | NOAEL | - | Human | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
Showing 10 of 10 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Plant Extract
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
AMYGDALIN
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
Is Amygdalin used in cosmetics?
Yes, Amygdalin is also indexed as a cosmetic ingredient under the name Amygdalin. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Amygdalin come from?
Safety data is sourced from EPA ToxValDB, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Amygdalin have different safety status in cosmetics vs industrial chemicals?
Amygdalin is prohibited in EU cosmetics but has active industrial GHS classifications (H302).
Is Amygdalin used outside industrial chemicals?
Amygdalin also appears in cosmetics, pharmaceutical, cannabis databases.