Is Amygdalin safe in cosmetics?
Amygdalin has a safety rating of "POOR" in our database. EU status: prohibited. US status: prohibited. 2 toxicological study endpoint(s) are available in our database.
Amygdalin
Also known as: Benzeneacetonitrile, α-[(6-O-β-D-glucopyranosyl-β-D-glucopyranosyl)oxy]-, (αR)-, Benzeneacetonitrile, α-[(6-O-β-D-glucopyranosyl-β-D-glucopyranosyl)oxy]-, (R)-, (αR)-α-[(6-O-β-D-Glucopyranosyl-β-D-glucopyranosyl)oxy]benzeneacetonitrile, D-Amygdalin, Mandelonitrile-β-gentiobioside (+5 more)
INCI: AMYGDALIN
Amygdalin (CAS 29883-15-6) is a cosmetic cosmetic ingredient functioning as skin conditioning. Reported NOAEL =0.105 mg/kg bw in Human (EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx); EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 29883-15-6 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Amygdalin is prohibited in EU cosmetics but has active industrial GHS classifications (H302).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
skin conditioning
Safety Rating
POOR
Chemistry & Identifiers
IUPAC Name
(2R)-2-phenyl-2-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]oxan-2-yl]oxyacetonitrile
InChIKey
XUCIJNAGGSZNQT-JHSLDZJXSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
prohibited
US Notes
Not approved for cosmetic use; poses cyanide toxicity risk via beta-glucosidase hydrolysis
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Amygdalin.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Amygdalin. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =0.105 mg/kg bw | - | Human | study with volunteers | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| NOAEL | =0.105 mg/kg bw | - | Human | study with volunteers | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
Expert Verdict
Expert safety assessment and concern-level summary for Amygdalin.
Regulatory Flags
cyanogenic_glycoside
eu_prohibited
cyanide_risk
systemic_toxicity
avoid
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Amygdalin by CAS number or substance name.
Studies
2
Lowest NOAEL
0.105 mg/kg bw
Highest NOAEL
0.105 mg/kg bw
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
Known Synonyms
Benzeneacetonitrile, α-[(6-O-β-D-glucopyranosyl-β-D-glucopyranosyl)oxy]-, (αR)-
Benzeneacetonitrile, α-[(6-O-β-D-glucopyranosyl-β-D-glucopyranosyl)oxy]-, (R)-
(αR)-α-[(6-O-β-D-Glucopyranosyl-β-D-glucopyranosyl)oxy]benzeneacetonitrile
D-Amygdalin
Mandelonitrile-β-gentiobioside
(R)-Amygdalin
NSC 15780
(-)-Amygdalin
Amygdaloside
Amygdaloside (disaccharide)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
AMYGDALIN
ChEMBL ID
CHEMBL461727
Frequently Asked Questions
Is Amygdalin allowed in the EU?
Amygdalin EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Amygdalin do in cosmetics?
Amygdalin functions as: skin conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 29883-15-6.
What is the NOAEL for Amygdalin?
The NOAEL (No Observed Adverse Effect Level) for Amygdalin is =0.105 mg/kg bw based on a study with volunteers study via oral route in Human. A total of 2 study endpoints are available. Source: EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx.
Is Amygdalin used outside cosmetics?
Amygdalin also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Amygdalin have different safety status in cosmetics vs industrial chemicals?
Amygdalin is prohibited in EU cosmetics but has active industrial GHS classifications (H302).
Compliance Tools
Check Amygdalin compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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