What is the NOAEL for Calcium D-gluconate?
Calcium D-gluconate has 5 NOAEL studies in the database. The lowest reported value is SQE6VB453K UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Calcium D-gluconate
Also known as: EINECS 206-075-8, Gluconato di calcio, UNII-SQE6VB453K
CAS 299-28-5
Calcium D-gluconate (CAS 299-28-5) is a chemical substance. Key regulatory status: REACH registered, 7 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.
SOURCE
noael studies public
NOAEL studies
5
SOURCE
chemical inventory jurisdictions
Regulatory lists
7
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
9 fields
Name
Calcium D-gluconate
CAS Number
299-28-5
DTXSID
DTXSID2029618
Molecular Formula
2C6H12O7.Ca
InChI Key
NEEHYRZPVYRGPP-IYEMJOQQSA-L
Monoisotopic Mass
432.079196
Synonyms
EINECS 206-075-8Gluconato di calcioUNII-SQE6VB453K
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
ILO/WHO International Chemical Safety Cards
1 records
| Field | Value |
|---|---|
| GHS Hazard Statements | No hazard classification according to GHS criteria |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
19 records
HumectantSoftener and conditionerFlavouring and nutrientChelating agentThickening agentProcessing aids not otherwise specifiedStabilizing agent
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
7 records
| List | Keyword | Source |
|---|---|---|
| pharmaceutical | FDA | United States Food and Drug Administration (FDA) |
| active_ingredient; animal_products; Europe; pharmaceutical; residue | EU | CPCat |
| Europe; supplements | EU | CPCat |
| Europe; food_additive; supplements | EU | CPCat |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
| Canada; pharmaceutical | DrugBank | DrugBank |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 5 of 5 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| SQE6VB453K | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| SQE6VB453K | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| SQE6VB453K | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| SQE6VB453K | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 400 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
Showing 5 of 5 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Calcium gluconate | 206-075-8 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
chelating agent
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CALCIUM GLUCONATE
ChEMBL Phase
4
Adverse Events
3339
Bioactivity
0
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
2 records
E578 — ADI: NOT SPECIFIED mg/kg bw | FDA GRAS: FDA has no questions
View full food safety profile →Frequently Asked Questions
What regulatory lists include Calcium D-gluconate?
Calcium D-gluconate appears on 7 regulatory/inventory lists including pharmaceutical, active_ingredient; animal_products; Europe; pharmaceutical; residue, Europe; supplements, and 4 more. Source: EPA CPDat.
Is Calcium D-gluconate used in cosmetics?
Yes, Calcium D-gluconate is also indexed as a cosmetic ingredient under the name Calcium Gluconate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Calcium D-gluconate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS. All data traces to primary regulatory sources and is updated from official government databases.
Is Calcium D-gluconate used outside industrial chemicals?
Calcium D-gluconate also appears in cosmetics, pharmaceutical, food safety databases.