Is Calcium Gluconate safe in cosmetics?
Calcium Gluconate has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted. This ingredient has been reviewed by cir.
Calcium Gluconate
Also known as: EINECS 206-075-8, Gluconato di calcio, UNII-SQE6VB453K
INCI: CALCIUM GLUCONATE
Calcium Gluconate (CAS 299-28-5) is a cosmetic cosmetic ingredient functioning as Chelating agent, Skin conditioning agent. EU Regulation 1223/2009 status: permitted; 1 safety opinion reviewed (cir). Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
View industrial chemical safety profile for CAS 299-28-5 →
Auto-generated CPSR Part A draft with source citations
Function
Chelating agent, Skin conditioning agent
Safety Rating
EXCELLENT
Chemistry & Identifiers
IUPAC Name
calcium bis((2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoate)
InChIKey
NEEHYRZPVYRGPP-IYEMJOQQSA-L
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
FDA GRAS under 21 CFR 184.1199 as food additive (firming agent, sequestrant, texturizer). Also used as inactive ingredient in approved drug products. No sunscreen classification; no cosmetic restrictions apply.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Calcium Gluconate.
Calculate MoS for your specific formulation with the MoS Calculator.
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Hazard Statements
No hazard classification according to GHS criteria
Safety Opinions
Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).
cir
Verdict: unknown
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Additional Ingredient Properties
1 property record from structured ingredient metadata.
mineral_clay
{"cas_number": "299-28-5", "ingredient_class": "calcium_compound", "chemical_formula": "Ca(C6H11O7)2", "mineral_origin": "synthetic", "particle_size_range_um": "20-300", "surface_area_m2_per_g": "0.5-3", "crystal_structure": "amorphous", "color_appearance": "white", "opacity": "opaque", "refractive_index": "1.52", "oil_absorption_g_per_100g": "80-200", "water_absorption_capacity": "low", "surface_…
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
ICSC Safety Card
1736
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Regulatory (2)
JECFA Evaluation
CALCIUM GLUCONATE | 1998 | NOT SPECIFIED | Group ADI for glucono delta-lactone, calcium gluconate, magnesium gluconate, potassium gluconate, and sodium gluconate | TRS 891-JECFA 51/46 | FAS 42-JECFA 51/203
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
EU Food Improvement
Food additives
Source: EU Food Improvement Agents
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Chelating agent
Flavouring and nutrient
Humectant
Processing aids not otherwise specified
Softener and conditioner
Stabilizing agent
Thickening agent
Regulatory List Membership (2)
EPA Safer Chemical Ingredients List (SCIL)
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Calcium Gluconate.
Regulatory Flags
gras
cir-safe
eu-unrestricted
cosmos-eligible
low-absorption
chelating-agent
no-sccs-opinion-needed
epa_safer_alternative
fda_food_additive
jecfa_safe
Known Synonyms
EINECS 206-075-8
Gluconato di calcio
UNII-SQE6VB453K
Chemical Function
Humectant
Softener and conditioner
Flavouring and nutrient
Chelating agent
Regulatory Lists
pharmaceutical
active_ingredient; animal_products; Europe; pharmaceutical; residue
Europe; supplements
Europe; food_additive; supplements
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
SCIL (9/2019)
Canada; pharmaceutical
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
CALCIUM GLUCONATE
ChEMBL ID
CHEMBL2106119
Max Phase
4
Adverse Event Associations
3339
SOURCE
EFSA / FDA GRAS
food_additives + fda_gras_enriched
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
Calcium gluconate
E Number
E578
ADI
NOT SPECIFIED mg/kg bw
FDA GRAS
FDA has no questions
GRN
136
Food Category
preservative
Use in food in general as a source of calcium
View full food safety profile →Frequently Asked Questions
Is Calcium Gluconate allowed in the EU?
Calcium Gluconate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Calcium Gluconate do in cosmetics?
Calcium Gluconate functions as: Chelating agent, Skin conditioning agent. It is classified as a cosmetic ingredient in our database. CAS number: 299-28-5.
Is Calcium Gluconate used outside cosmetics?
Calcium Gluconate also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Calcium Gluconate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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