Calcium Gluconate
INCI: CALCIUM GLUCONATE
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Calcium Gluconate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 400 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| dose_tested | 400 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Safety Opinions
Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).
Expert Verdict
Calcium Gluconate (CAS 299-28-5) is unrestricted in the EU under Regulation (EC) No 1223/2009 and FDA GRAS in the US under 21 CFR 184.1199. CIR Panel (2014) determined it safe as used in cosmetics. Functions as a chelating and skin conditioning agent with negligible dermal absorption and no sensitization concerns.
Regulatory Flags
Frequently Asked Questions
Is Calcium Gluconate safe in cosmetics?
Calcium Gluconate (CAS 299-28-5) is unrestricted in the EU under Regulation (EC) No 1223/2009 and FDA GRAS in the US under 21 CFR 184.1199. CIR Panel (2014) determined it safe as used in cosmetics. Functions as a chelating and skin conditioning agent with negligible dermal absorption and no sensitization concerns. The EU classifies Calcium Gluconate as "permitted". Safety rating: EXCELLENT. 2 toxicological study endpoint(s) are available in our database. This ingredient has been reviewed by cir.
Is Calcium Gluconate allowed in the EU?
Calcium Gluconate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Calcium Gluconate do in cosmetics?
Calcium Gluconate functions as: Chelating agent, Skin conditioning agent. It is classified as a cosmetic ingredient in our database. CAS number: 299-28-5.
What is the Margin of Safety for Calcium Gluconate?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Calcium Gluconate?
The NOAEL (No Observed Adverse Effect Level) for Calcium Gluconate is 400 mg/kg bw/day based on a Short Term Toxicity study via oral route in rat. A total of 2 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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